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Sökning: onr:"swepub:oai:DiVA.org:oru-87594" > Insights in the reg...

Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears

Ebert, Thomas (författare)
Karolinska Institutet
Painer, Johanna (författare)
Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
Bergman, Peter (författare)
Karolinska Institutet
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Qureshi, Abdul Rashid (författare)
Karolinska Institutet
Giroud, Sylvain (författare)
Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
Stalder, Gabrielle (författare)
Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
Kublickiene, Karolina (författare)
Karolinska Institutet
Göritz, Frank (författare)
Leibniz Institute for Zoo and Wildlife Ecology, Berlin, Germany
Vetter, Sebastian (författare)
Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
Bieber, Claudia (författare)
Department of Interdisciplinary Life Sciences, Research Institute of Wildlife Ecology, Veterinary University Vienna, Vienna, Austria
Fröbert, Ole, 1964- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Cardiology
Arnemo, Jon (författare)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Inland Norway University of Applied Sciences
Zedrosser, Andreas (författare)
Department of Natural Sciences and Environmental Health, University of South-Eastern Norway, Bø i Telemark, Norway; Institute for Wildlife Biology and Game Management, University for Natural Resources and Life Sciences, Vienna, Austria
Redtenbacher, Irene (författare)
Four Paws International, Vienna, Austria
Shiels, Paul G. (författare)
Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK
Johnson, Richard J. (författare)
Division of Renal Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Stenvinkel, Peter (författare)
Karolinska Institutet
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 (creator_code:org_t)
 
2020-11-23
2020
Engelska.
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 10:1
Relaterad länk:
https://doi.org/10.1...
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https://www.nature.c...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://res.slu.se/i...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardiometabolic diseases and chronic kidney disease (CKD), in part via metabolism of ingested food. Using a comparative biomimetic approach, we have investigated circulating levels of the gut metabolites betaine, choline, and TMAO in human CKD, across animal species as well as during hibernation in two animal species. Betaine, choline, and TMAO levels were associated with renal function in humans and differed significantly across animal species. Free-ranging brown bears showed a distinct regulation pattern with an increase in betaine (422%) and choline (18%) levels during hibernation, but exhibited undetectable levels of TMAO. Free-ranging brown bears had higher betaine, lower choline, and undetectable TMAO levels compared to captive brown bears. Endogenously produced betaine may protect bears and garden dormice during the vulnerable hibernating period. Carnivorous eating habits are linked to TMAO levels in the animal kingdom. Captivity may alter the microbiota and cause a subsequent increase of TMAO production. Since free-ranging bears seems to turn on a metabolic switch that shunts choline to generate betaine instead of TMAO, characterisation and understanding of such an adaptive switch could hold clues for novel treatment options in burden of lifestyle diseases, such as CKD.

Ämnesord

NATURVETENSKAP  -- Biologi -- Etologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Behavioural Sciences Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Zoologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Zoology (hsv//eng)

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