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Bedtime dosing of a...
Bedtime dosing of antihypertensive medications: systematic review and consensus statement : International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension
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- Stergiou, George (författare)
- Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
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- Brunström, Mattias (författare)
- Umeå universitet,Avdelningen för medicin
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- MacDonald, Thomas (författare)
- Director of MEMO Research, Ninewells Hospital & Medical School, University of Dundee, United Kingdom
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- Kyriakoulis, Konstantinos G. (författare)
- Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
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- Bursztyn, Michael (författare)
- Hypertension Clinic, Hadassah-Hebrew University Medical Center, Faculty of Medicine, Hadassah-Hebrew University School of Medicine, Department of Medicine D, Beilinson Hospital, Israel
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- Khan, Nadia (författare)
- Department of Medicine, University of British Columbia, Center for Health Evaluation and Outcomes Sciences, Vancouver, Canada
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- Bakris, George (författare)
- Department of Medicine, University of Chicago Medicine, IL, Chicago, United States
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- Kollias, Anastasios (författare)
- Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
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- Menti, Ariadni (författare)
- Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece
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- Muntner, Paul (författare)
- School of Public Health, University of Alabama at Birmingham, AL, Birmingham, United States
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- Orias, Marcelo (författare)
- Yale University, CT, New Haven, United States
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- Poulter, Neil (författare)
- Imperial Clinical Trials Unit, School of Public Health, Imperial College London, Stadium House, London, United Kingdom
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- Shimbo, Daichi (författare)
- Columbia Hypertension Center and Lab, Department of Medicine, Columbia University Irving Medical Center, NY, United States
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- Williams, Bryan (författare)
- Institute of Cardiovascular Science, University College London, London, United Kingdom
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- Adeoye, Abiodun Moshood (författare)
- Cardiovascular Genetics and Genomic Research Unit, Institute of Cardiovascular Diseases, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria
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- Damasceno, Albertino (författare)
- Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique
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- Korostovtseva, Lyudmila (författare)
- Almazov National Medical Research Centre, St Petersburg, Russian Federation
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- Li, Yan (författare)
- Department of Cardiovascular Medicine, Shanghai Institute of Hypertension, Shanghai Key Lab of Hypertension, National Research Centre for Translational Medicine, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
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- Muxfeldt, Elizabeth (författare)
- , Universidade Federal do Rio de Janeiro - Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brazil
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- Zhang, Yuqing (författare)
- Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
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- Mancia, Giuseppe (författare)
- University of Milano-Bicocca, Milan, Italy
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- Kreutz, Reinhold (författare)
- Charité - Universitätsmedizin Berlin, Institute of Clinical Pharmacology and Toxicology, Berlin, Germany
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- Tomaszewski, Maciej (författare)
- Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester; Manchester Heart Centre and Manchester Academic Health Science Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2022
- 2022
- Engelska.
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Ingår i: Journal of Hypertension. - : Lippincott Williams & Wilkins. - 0263-6352 .- 1473-5598. ; 40:10, s. 1847-1858
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Antihypertensive drug therapy is one of the most efficient medical interventions for preventing disability and death globally. Most of the evidence supporting its benefits has been derived from outcome trials with morning dosing of medications. Accumulating evidence suggests an adverse prognosis associated with night-time hypertension, nondipping blood pressure (BP) profile and morning BP surge, with increased incidence of cardiovascular events during the first few morning hours. These observations provide justification for complete 24-h BP control as being the primary goal of antihypertensive treatment. Bedtime administration of antihypertensive drugs has also been proposed as a potentially more effective treatment strategy than morning administration. This Position Paper by the International Society of Hypertension reviewed the published evidence on the clinical relevance of the diurnal variation in BP and the timing of antihypertensive drug treatment, aiming to provide consensus recommendations for clinical practice. Eight published outcome hypertension studies involved bedtime dosing of antihypertensive drugs, and all had major methodological and/or other flaws and a high risk of bias in testing the impact of bedtime compared to morning treatment. Three ongoing, well designed, prospective, randomized controlled outcome trials are expected to provide high-quality data on the efficacy and safety of evening or bedtime versus morning drug dosing. Until that information is available, preferred use of bedtime drug dosing of antihypertensive drugs should not be routinely recommended in clinical practice. Complete 24-h control of BP should be targeted using readily available, long-acting antihypertensive medications as monotherapy or combinations administered in a single morning dose.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- ambulatory blood pressure monitoring
- antihypertensive drugs
- bedtime administration
- chronotherapy
- dipper
- nocturnal blood pressure
- systematic review
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Stergiou, George
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Brunström, Matti ...
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MacDonald, Thoma ...
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Kyriakoulis, Kon ...
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Bursztyn, Michae ...
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Khan, Nadia
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Bakris, George
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Kollias, Anastas ...
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Menti, Ariadni
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Muntner, Paul
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Orias, Marcelo
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Poulter, Neil
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Shimbo, Daichi
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Williams, Bryan
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Adeoye, Abiodun ...
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Damasceno, Alber ...
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Korostovtseva, L ...
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Li, Yan
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Muxfeldt, Elizab ...
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Zhang, Yuqing
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Mancia, Giuseppe
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Kreutz, Reinhold
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Tomaszewski, Mac ...
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