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Sökning: onr:"swepub:oai:DiVA.org:umu-41629" > Tumor necrosis fact...

Tumor necrosis factor (TNF)-α, soluble TNF receptors and endometrial cancer risk : the EPIC study

Dossus, Laure (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Becker, Susen (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Rinaldi, Sabina (författare)
Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France
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Lukanova, Annekatrin (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Tjønneland, Anne (författare)
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Olsen, Anja (författare)
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Overvad, Kim (författare)
Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
Chabbert-Buffet, Nathalie (författare)
Department of Obstetrics and Gynecology, APHP Hospital Tenon and UMPC, Paris, France
Boutron-Ruault, Marie-Christine (författare)
INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
Clavel-Chapelon, Françoise (författare)
INSERM, Centre for Research in Epidemiology and Population Health, Paris South University, Gustave Roussy Institute, Villejuif, France
Teucher, Birgit (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Pischon, Tobias (författare)
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Boeing, Heiner (författare)
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Trichopoulou, Antonia (författare)
Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
Benetou, Vasiliki (författare)
Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
Valanou, Elisavet (författare)
Department of Hygiene, Epidemiology and Medical Statistics, WHO Collaborating Center for Food and Nutrition Policies, University of Athens Medical School, Athens, Greece
Palli, Domenico (författare)
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), Florence, Italy
Sieri, Sabina (författare)
Department of Preventive and Predictive Medicine, Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Unit, “Civile – M.P. Arezzo” Hospital, Ragusa, Italy
Sacerdote, Carlotta (författare)
Center for Cancer Prevention (CPO Piedmont), Turin, Italy
Galasso, Rocco (författare)
Instituto di Ricovero e Cura a Carattere Scientifico (IRCCS-CROOB), Rionero in Vulture (PZ), Italy
Redondo, Maria-Luísa (författare)
Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain
Bonet Bonet, Catalina (författare)
Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain
Molina-Montes, Esther (författare)
Andalusian School of Public Health, Granada, Spain
Altzibar, Jone M (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
Chirlaque, Maria-Dolores (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
Ardanaz, Eva (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
Bueno-de-Mesquita, H Bas (författare)
CIBER de Epidemiología y Salud Pública (CIBERESP), Spain
van Duijnhoven, Fränzel J B (författare)
National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands
Peeters, Petra H M (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Onland-Moret, N Charlotte (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
Lundin, Eva (författare)
Umeå universitet,Patologi
Idahl, Annika (författare)
Umeå universitet,Obstetrik och gynekologi,Institutionen för folkhälsa och klinisk medicin
Khaw, Kay-Tee (författare)
Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Wareham, Nicholas (författare)
MRC Epidemiology Unit, Cambridge, United Kingdom
Allen, Naomi (författare)
Nuffield Department of Clinical Medicine, Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Romieu, Isabelle (författare)
International Agency for Research on Cancer, Lyon, France
Fedirko, Veronika (författare)
International Agency for Research on Cancer, Lyon, France
Hainaut, Pierre (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
Romaguera, Dora (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
Norat, Teresa (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
Riboli, Elio (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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 (creator_code:org_t)
2011-03-08
2011
Engelska.
Ingår i: International Journal of Cancer. - Geneve : International union against cancer. - 0020-7136 .- 1097-0215. ; 129:8, s. 2032-2037
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Chronic inflammation has been hypothesized to play a role in endometrial cancer development. Tumor necrosis factor-α (TNF-α), one of the major pro-inflammatory cytokines, has also been implicated in endometrial physiology. We conducted a case-control study nested within the European prospective investigation into cancer and nutrition (EPIC) to examine the association of TNF-α and its two soluble receptors (sTNFR1 and sTNFR2) with endometrial cancer risk. Two-hundred-seventy cases and 518 matched controls were analyzed using conditional logistic regression. All statistical tests were two-sided. We observed an increased risk of endometrial cancer among women in the highest versus lowest quartile of TNF-α (odds ratio [OR]: 1.73, 95% CI: 1.09-2.73, Ptrend = 0.01), sTNFR1 (OR: 1.68, 95% CI: 0.99-2.86, Ptrend = 0.07) and sTNFR2 (OR: 1.53, 95%CI: 0.92-2.55, Ptrend = 0.03) after adjustment for body-mass-index, parity, age at menopause and previous postmenopausal hormone therapy use. Further adjustments for estrogens and C-peptide had minor effect on risk estimates. Our data show that elevated prediagnostic concentrations of TNF-α and its soluble receptors are related to a higher risk of endometrial cancer, particularly strong in women diagnosed within 2 years of blood donation. This is the first study of its kind and therefore deserves replication in further prospective studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

tumor necrosis factor (TNF)-α
soluble TNF receptors
inflammation
endometrial cancer
prospective
MEDICINE
MEDICIN
Pathology
patologi

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