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Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study

Dixon-Suen, Suzanne C (author)
Cancer Council Victoria
Lewis, Sarah J (author)
Martin, Richard M (author)
show more...
English, Dallas R (author)
Boyle, Terry (author)
Giles, Graham G (author)
Michailidou, Kyriaki (author)
Bolla, Manjeet K (author)
Wang, Qin (author)
Dennis, Joe (author)
Lush, Michael (author)
Investigators, Abctb (author)
Ahearn, Thomas U (author)
Ambrosone, Christine B (author)
Andrulis, Irene L (author)
Karolinska Institutet
Anton-Culver, Hoda (author)
Arndt, Volker (author)
Aronson, Kristan J (author)
Augustinsson, A. (author)
Lund University,Lunds universitet,Karolinska Institutet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Biomarkers and epidemiology,Department of Clinical Sciences, Lund
Auvinen, Päivi (author)
Beane Freeman, Laura E (author)
Becher, Heiko (author)
Beckmann, Matthias W (author)
Behrens, Sabine (author)
Bermisheva, Marina (author)
University of Melbourne,Cancer Council Victoria
Blomqvist, Carl (author)
Bogdanova, Natalia V (author)
Bojesen, Stig E (author)
Bonanni, Bernardo (author)
Brenner, Hermann (author)
Brüning, Thomas (author)
Buys, Saundra S (author)
Camp, Nicola J (author)
Campa, Daniele (author)
Canzian, Federico (author)
Castelao, Jose E (author)
Cessna, Melissa H (author)
Chang-Claude, Jenny (author)
Chanock, Stephen J (author)
Clarke, Christine L (author)
Conroy, Don M (author)
Couch, Fergus J (author)
Cox, Angela (author)
Cross, Simon S (author)
Czene, Kamila (author)
Karolinska Institutet
Daly, Mary B (author)
Devilee, Peter (author)
Dörk, Thilo (author)
Dwek, Miriam (author)
Eccles, Diana M (author)
Eliassen, A Heather (author)
Engel, Christoph (author)
Eriksson, Mikael (author)
Karolinska Institutet
Evans, D Gareth (author)
Fasching, Peter A (author)
Fletcher, Olivia (author)
Flyger, Henrik (author)
Fritschi, Lin (author)
Gabrielson, Marike (author)
Karolinska Institutet
Gago-Dominguez, Manuela (author)
García-Closas, Montserrat (author)
García-Sáenz, José A (author)
Goldberg, Mark S (author)
Guénel, Pascal (author)
Gündert, Melanie (author)
Hahnen, Eric (author)
Haiman, Christopher A (author)
Häberle, Lothar (author)
Håkansson, Niclas (author)
Karolinska Institutet
Hall, Per (author)
Karolinska Institutet
Hamann, Ute (author)
Hart, Steven N (author)
Harvie, Michelle (author)
Hillemanns, Peter (author)
Hollestelle, Antoinette (author)
Hooning, Maartje J (author)
Hoppe, Reiner (author)
Hopper, John (author)
Howell, Anthony (author)
Hunter, David J (author)
Jakubowska, Anna (author)
Janni, Wolfgang (author)
John, Esther M (author)
Jung, Audrey (author)
Kaaks, Rudolf (author)
Keeman, Renske (author)
Kitahara, Cari M (author)
Koutros, Stella (author)
Kraft, Peter (author)
Kristensen, Vessela N (author)
Kubelka-Sabit, Katerina (author)
Kurian, Allison W (author)
Lacey, James V (author)
Lambrechts, Diether (author)
Le Marchand, Loic (author)
Lindblom, Annika (author)
Loibl, Sibylle (author)
Lubiński, Jan (author)
Mannermaa, Arto (author)
Manoochehri, Mehdi (author)
Margolin, Sara (author)
Karolinska Institutet
Martinez, Maria Elena (author)
Mavroudis, Dimitrios (author)
Menon, Usha (author)
Mulligan, Anna Marie (author)
Murphy, Rachel A (author)
Collaborators, Nbcs (author)
Nevanlinna, Heli (author)
Nevelsteen, Ines (author)
Newman, William G (author)
Offit, Kenneth (author)
Olshan, Andrew F (author)
Olsson, H. (author)
Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
Orr, Nick (author)
Patel, Alpa (author)
Peto, Julian (author)
Plaseska-Karanfilska, Dijana (author)
Presneau, Nadege (author)
Rack, Brigitte (author)
Radice, Paolo (author)
Rees-Punia, Erika (author)
Rennert, Gad (author)
Rennert, Hedy S (author)
Romero, Atocha (author)
Saloustros, Emmanouil (author)
Sandler, Dale P (author)
Schmidt, Marjanka K (author)
Schmutzler, Rita K (author)
Schwentner, Lukas (author)
Scott, Christopher (author)
Shah, Mitul (author)
Shu, Xiao-Ou (author)
Simard, Jacques (author)
Southey, Melissa C (author)
Stone, Jennifer (author)
Surowy, Harald (author)
Swerdlow, Anthony J (author)
Tamimi, Rulla M (author)
Tapper, William J (author)
Taylor, Jack A (author)
Terry, Mary Beth (author)
Tollenaar, Rob A E M (author)
Troester, Melissa A (author)
Truong, Thérèse (author)
Untch, Michael (author)
Vachon, Celine M (author)
Joseph, Vijai (author)
Wappenschmidt, Barbara (author)
Weinberg, Clarice R (author)
Wolk, Alicja (author)
Uppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
Yannoukakos, Drakoulis (author)
Zheng, Wei (author)
Ziogas, Argyrios (author)
Dunning, Alison M (author)
Pharoah, Paul D P (author)
Easton, Douglas F (author)
Milne, Roger L (author)
Lynch, Brigid M (author)
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 (creator_code:org_t)
 
2022-09-06
2022
English.
In: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 56:20, s. 1157-1170
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Keyword

Breast
Genetics
Physical activity
Sedentary Behaviour

Publication and Content Type

ref (subject category)
art (subject category)

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Dixon-Suen, Suza ...
Lewis, Sarah J
Martin, Richard ...
English, Dallas ...
Boyle, Terry
Giles, Graham G
show more...
Michailidou, Kyr ...
Bolla, Manjeet K
Wang, Qin
Dennis, Joe
Lush, Michael
Investigators, A ...
Ahearn, Thomas U
Ambrosone, Chris ...
Andrulis, Irene ...
Anton-Culver, Ho ...
Arndt, Volker
Aronson, Kristan ...
Augustinsson, A.
Auvinen, Päivi
Beane Freeman, L ...
Becher, Heiko
Beckmann, Matthi ...
Behrens, Sabine
Bermisheva, Mari ...
Blomqvist, Carl
Bogdanova, Natal ...
Bojesen, Stig E
Bonanni, Bernard ...
Brenner, Hermann
Brüning, Thomas
Buys, Saundra S
Camp, Nicola J
Campa, Daniele
Canzian, Federic ...
Castelao, Jose E
Cessna, Melissa ...
Chang-Claude, Je ...
Chanock, Stephen ...
Clarke, Christin ...
Conroy, Don M
Couch, Fergus J
Cox, Angela
Cross, Simon S
Czene, Kamila
Daly, Mary B
Devilee, Peter
Dörk, Thilo
Dwek, Miriam
Eccles, Diana M
Eliassen, A Heat ...
Engel, Christoph
Eriksson, Mikael
Evans, D Gareth
Fasching, Peter ...
Fletcher, Olivia
Flyger, Henrik
Fritschi, Lin
Gabrielson, Mari ...
Gago-Dominguez, ...
García-Closas, M ...
García-Sáenz, Jo ...
Goldberg, Mark S
Guénel, Pascal
Gündert, Melanie
Hahnen, Eric
Haiman, Christop ...
Häberle, Lothar
Håkansson, Nicla ...
Hall, Per
Hamann, Ute
Hart, Steven N
Harvie, Michelle
Hillemanns, Pete ...
Hollestelle, Ant ...
Hooning, Maartje ...
Hoppe, Reiner
Hopper, John
Howell, Anthony
Hunter, David J
Jakubowska, Anna
Janni, Wolfgang
John, Esther M
Jung, Audrey
Kaaks, Rudolf
Keeman, Renske
Kitahara, Cari M
Koutros, Stella
Kraft, Peter
Kristensen, Vess ...
Kubelka-Sabit, K ...
Kurian, Allison ...
Lacey, James V
Lambrechts, Diet ...
Le Marchand, Loi ...
Lindblom, Annika
Loibl, Sibylle
Lubiński, Jan
Mannermaa, Arto
Manoochehri, Meh ...
Margolin, Sara
Martinez, Maria ...
Mavroudis, Dimit ...
Menon, Usha
Mulligan, Anna M ...
Murphy, Rachel A
Collaborators, N ...
Nevanlinna, Heli
Nevelsteen, Ines
Newman, William ...
Offit, Kenneth
Olshan, Andrew F
Olsson, H.
Orr, Nick
Patel, Alpa
Peto, Julian
Plaseska-Karanfi ...
Presneau, Nadege
Rack, Brigitte
Radice, Paolo
Rees-Punia, Erik ...
Rennert, Gad
Rennert, Hedy S
Romero, Atocha
Saloustros, Emma ...
Sandler, Dale P
Schmidt, Marjank ...
Schmutzler, Rita ...
Schwentner, Luka ...
Scott, Christoph ...
Shah, Mitul
Shu, Xiao-Ou
Simard, Jacques
Southey, Melissa ...
Stone, Jennifer
Surowy, Harald
Swerdlow, Anthon ...
Tamimi, Rulla M
Tapper, William ...
Taylor, Jack A
Terry, Mary Beth
Tollenaar, Rob A ...
Troester, Meliss ...
Truong, Thérèse
Untch, Michael
Vachon, Celine M
Joseph, Vijai
Wappenschmidt, B ...
Weinberg, Claric ...
Wolk, Alicja
Yannoukakos, Dra ...
Zheng, Wei
Ziogas, Argyrios
Dunning, Alison ...
Pharoah, Paul D ...
Easton, Douglas ...
Milne, Roger L
Lynch, Brigid M
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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and Public Health Gl ...
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Uppsala University
Karolinska Institutet
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