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Frailty and bone he...
Frailty and bone health in European men
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- Cook, Michael J. (author)
- University of Manchester
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- Oldroyd, Alexander (author)
- University of Manchester
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- Pye, Stephen R (author)
- University of Manchester,Great Ormond Street Hospital
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- Ward, Kate A (author)
- MRC Human Nutrition Research
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- Gielen, Evelien (author)
- Catholic University of Leuven
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- Ravindrarajah, Rathi (author)
- King's College London
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- Adams, Judith E (author)
- University of Manchester
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- Lee, David M (author)
- University of Manchester
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- Bartfai, Gyorgy (author)
- University of Szeged
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- Boonen, Steven (author)
- Catholic University of Leuven
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- Casanueva, Felipe (author)
- CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN)
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- Forti, Gianni (author)
- University of Florence
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- Giwercman, Aleksander (author)
- Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups
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- Han, Thang S (author)
- Royal Holloway University of London
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- Huhtaniemi, Ilpo T. (author)
- Imperial College London
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- Kula, Krzysztof (author)
- Medical University of Lodz
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- Lean, Michael E. (author)
- University of Glasgow
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- Pendleton, Neil (author)
- University of Manchester
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- Punab, Margus (author)
- Tartu University Hospital
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- Vanderschueren, Dirk (author)
- Catholic University of Leuven
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- Wu, Frederick C (author)
- University of Manchester
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- O'Neill, Terence W. (author)
- Great Ormond Street Hospital
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Petrone, Luisa (author)
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Cilotti, Antonio (author)
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Borghs, Herman (author)
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Slowikowska-Hilczer, Jolanta (author)
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Walczak-Jedrzejowska, Renata (author)
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Huhtaniemi, Ilpo (author)
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Wu, Frederick Cw (author)
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Silman, Alan (author)
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O'Neill, Terence (author)
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Finn, Joseph D (author)
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Steer, Philip (author)
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Tajar, Abdelouahid (author)
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Lee, David (author)
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Pye, Stephen (author)
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Ocampo, Marta (author)
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Lage, Mary (author)
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Földesi, Imre (author)
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Fejes, Imre (author)
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Korrovitz, Paul (author)
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Jiang, Min (author)
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(creator_code:org_t)
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- 2016-11-16
- 2017
- English 7 s.
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In: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 46:4, s. 635-641
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Background: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health.Methods: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA). Frailty was defined based on an adaptation of Fried's phenotype criteria and a frailty index (FI) was constructed. The association between frailty and the QUS and DXA parameters was determined using linear regression, with adjustments for age, body mass index and centre.Results: in total, 3,231 subjects contributed data to the analysis. Using the Fried categorisation of frailty, pre-frail and frail men had significantly lower speed of sound (SOS), broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) compared to robust men (P< 0.05). Similar results were seen using the FI after categorisation into 'high', 'medium' and 'low' levels of frailty. Using the Fried categorisation, frail men had lower femoral neck bone mineral density (BMD) compared to robust men (P < 0.05), but not lower lumbar spine BMD. Using the FI categorisation, a 'high' level of frailty (FI > 0.35) was associated with lower lumbar spine BMD (P < 0.05) when compared to those with low (FI < 0.2), but not lower femoral neck BMD. When analysed as a continuous variable, higher FI was linked with lower SOS, BUA and QUI (P < 0.05).Conclusions: optimisation of bone health as well as prevention of falls should be considered as strategies to reduce fractures in frail older people.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- bone mineral density
- Frailty
- heel ultrasound
- male health
- older people
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Cook, Michael J.
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Oldroyd, Alexand ...
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Pye, Stephen R
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Ward, Kate A
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Gielen, Evelien
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Ravindrarajah, R ...
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show more...
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Adams, Judith E
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Lee, David M
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Bartfai, Gyorgy
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Boonen, Steven
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Casanueva, Felip ...
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E.
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Pendleton, Neil
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Punab, Margus
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Vanderschueren, ...
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Wu, Frederick C
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O'Neill, Terence ...
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Petrone, Luisa
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Cilotti, Antonio
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Borghs, Herman
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Slowikowska-Hilc ...
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Walczak-Jedrzejo ...
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Huhtaniemi, Ilpo
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Wu, Frederick Cw
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Silman, Alan
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O'Neill, Terence
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Finn, Joseph D
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Steer, Philip
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Tajar, Abdelouah ...
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Lee, David
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Pye, Stephen
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Ocampo, Marta
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Lage, Mary
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Földesi, Imre
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Fejes, Imre
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Korrovitz, Paul
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Jiang, Min
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Orthopaedics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
- Articles in the publication
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Age and Ageing
- By the university
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Lund University