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Genome-wide associa...
Genome-wide association mapping in a wild avian population identifies a link between genetic and phenotypic variation in a life-history trait
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- Husby, Arild (författare)
- Uppsala universitet,Zooekologi
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- Kawakami, Takeshi (författare)
- Uppsala universitet,Evolutionsbiologi
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- Rönnegård, Lars (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Högskolan Dalarna,Statistik,SLU,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences
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- Smeds, Linnea (författare)
- Uppsala universitet,Evolutionsbiologi
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- Ellegren, Hans (författare)
- Uppsala universitet,Evolutionsbiologi
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- Qvarnström, Anna (författare)
- Uppsala universitet,Zooekologi
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(creator_code:org_t)
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- 2015-05-07
- 2015
- Engelska.
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Ingår i: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 282:1806
- Relaterad länk:
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Understanding the genetic basis of traits involved in adaptation is a major challenge in evolutionary biology but remains poorly understood. Here, we use genome-wide association mapping using a custom 50 k single nucleotide polymorphism (SNP) array in a natural population of collared flycatchers to examine the genetic basis of clutch size, an important life-history trait in many animal species. We found evidence for an association on chromosome 18 where one SNP significant at the genome-wide level explained 3.9% of the phenotypic variance. We also detected two suggestive quantitative trait loci (QTLs) on chromosomes 9 and 26. Fitness differences among genotypes were generally weak and not significant, although there was some indication of a sex-by-genotype interaction for lifetime reproductive success at the suggestive QTL on chromosome 26. This implies that sexual antagonism may play a role in maintaining genetic variation at this QTL. Our findings provide candidate regions for a classic avian life-history trait that will be useful for future studies examining the molecular and cellular function of, as well as evolutionary mechanisms operating at, these loci.
Ämnesord
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
- NATURVETENSKAP -- Biologi -- Ekologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Ecology (hsv//eng)
Nyckelord
- clutch size
- egg production
- Ficedula albicollis
- fitness trait
- GWAS
- QTL
- General Microdata Analysis - methods
- Allmänt Mikrodataaanalys - metod
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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