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Genome-wide association study identifies five loci associated with lung function.

Repapi, Emmanouela (author)
Sayers, Ian (author)
Wain, Louise V (author)
show more...
Burton, Paul R (author)
Johnson, Toby (author)
Obeidat, Ma'en (author)
Zhao, Jing Hua (author)
Ramasamy, Adaikalavan (author)
Zhai, Guangju (author)
Vitart, Veronique (author)
Huffman, Jennifer E (author)
Igl, Wilmar (author)
Uppsala universitet,Institutionen för genetik och patologi
Albrecht, Eva (author)
Deloukas, Panos (author)
Henderson, John (author)
Granell, Raquel (author)
McArdle, Wendy L (author)
Rudnicka, Alicja R (author)
Barroso, Inês (author)
Loos, Ruth J F (author)
Wareham, Nicholas J (author)
Mustelin, Linda (author)
Rantanen, Taina (author)
Surakka, Ida (author)
Imboden, Medea (author)
Wichmann, H Erich (author)
Grkovic, Ivica (author)
Jankovic, Stipan (author)
Zgaga, Lina (author)
Hartikainen, Anna-Liisa (author)
Peltonen, Leena (author)
Gyllensten, Ulf (author)
Uppsala universitet,Institutionen för genetik och patologi
Johansson, Åsa (author)
Uppsala universitet,Institutionen för genetik och patologi
Zaboli, Ghazal (author)
Uppsala universitet,Institutionen för genetik och patologi
Campbell, Harry (author)
Wild, Sarah H (author)
Wilson, James F (author)
Gläser, Sven (author)
Homuth, Georg (author)
Völzke, Henry (author)
Mangino, Massimo (author)
Soranzo, Nicole (author)
Spector, Tim D (author)
Polasek, Ozren (author)
Rudan, Igor (author)
Wright, Alan F (author)
Heliövaara, Markku (author)
Ripatti, Samuli (author)
Pouta, Anneli (author)
Torinsson Naluai, Åsa, 1968 (author)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
Olin, Anna-Carin, 1960 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Torén, Kjell, 1952 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Cooper, Matthew N (author)
James, Alan L (author)
Palmer, Lyle J (author)
Hingorani, Aroon D (author)
Wannamethee, S Goya (author)
Whincup, Peter H (author)
Smith, George Davey (author)
Ebrahim, Shah (author)
McKeever, Tricia M (author)
Pavord, Ian D (author)
MacLeod, Andrew K (author)
Morris, Andrew D (author)
Porteous, David J (author)
Cooper, Cyrus (author)
Dennison, Elaine (author)
Shaheen, Seif (author)
Karrasch, Stefan (author)
Schnabel, Eva (author)
Schulz, Holger (author)
Grallert, Harald (author)
Bouatia-Naji, Nabila (author)
Delplanque, Jérôme (author)
Froguel, Philippe (author)
Blakey, John D (author)
Britton, John R (author)
Morris, Richard W (author)
Holloway, John W (author)
Lawlor, Debbie A (author)
Hui, Jennie (author)
Nyberg, Fredrik, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
Jarvelin, Marjo-Riitta (author)
Jackson, Cathy (author)
Kähönen, Mika (author)
Kaprio, Jaakko (author)
Probst-Hensch, Nicole M (author)
Koch, Beate (author)
Hayward, Caroline (author)
Evans, David M (author)
Elliott, Paul (author)
Strachan, David P (author)
Hall, Ian P (author)
Tobin, Martin D (author)
show less...
 (creator_code:org_t)
2009-12-13
2010
English.
In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:1, s. 36-44
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Keyword

lung function
whole genome association
genetic epidemiology
MEDICINE

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor
Repapi, Emmanoue ...
Sayers, Ian
Wain, Louise V
Burton, Paul R
Johnson, Toby
Obeidat, Ma'en
show more...
Zhao, Jing Hua
Ramasamy, Adaika ...
Zhai, Guangju
Vitart, Veroniqu ...
Huffman, Jennife ...
Igl, Wilmar
Albrecht, Eva
Deloukas, Panos
Henderson, John
Granell, Raquel
McArdle, Wendy L
Rudnicka, Alicja ...
Barroso, Inês
Loos, Ruth J F
Wareham, Nichola ...
Mustelin, Linda
Rantanen, Taina
Surakka, Ida
Imboden, Medea
Wichmann, H Eric ...
Grkovic, Ivica
Jankovic, Stipan
Zgaga, Lina
Hartikainen, Ann ...
Peltonen, Leena
Gyllensten, Ulf
Johansson, Åsa
Zaboli, Ghazal
Campbell, Harry
Wild, Sarah H
Wilson, James F
Gläser, Sven
Homuth, Georg
Völzke, Henry
Mangino, Massimo
Soranzo, Nicole
Spector, Tim D
Polasek, Ozren
Rudan, Igor
Wright, Alan F
Heliövaara, Mark ...
Ripatti, Samuli
Pouta, Anneli
Torinsson Naluai ...
Olin, Anna-Carin ...
Torén, Kjell, 19 ...
Cooper, Matthew ...
James, Alan L
Palmer, Lyle J
Hingorani, Aroon ...
Wannamethee, S G ...
Whincup, Peter H
Smith, George Da ...
Ebrahim, Shah
McKeever, Tricia ...
Pavord, Ian D
MacLeod, Andrew ...
Morris, Andrew D
Porteous, David ...
Cooper, Cyrus
Dennison, Elaine
Shaheen, Seif
Karrasch, Stefan
Schnabel, Eva
Schulz, Holger
Grallert, Harald
Bouatia-Naji, Na ...
Delplanque, Jérô ...
Froguel, Philipp ...
Blakey, John D
Britton, John R
Morris, Richard ...
Holloway, John W
Lawlor, Debbie A
Hui, Jennie
Nyberg, Fredrik, ...
Jarvelin, Marjo- ...
Jackson, Cathy
Kähönen, Mika
Kaprio, Jaakko
Probst-Hensch, N ...
Koch, Beate
Hayward, Carolin ...
Evans, David M
Elliott, Paul
Strachan, David ...
Hall, Ian P
Tobin, Martin D
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Health Sciences
and Public Health Gl ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Respiratory Medi ...
NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Genetics
Articles in the publication
Nature genetics
By the university
University of Gothenburg
Uppsala University

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