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Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men

Sigurdardottir, Lara G. (författare)
Icelandic Cancer Society, Reykjavik, Iceland; Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland
Markt, Sarah C. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
Sigurdsson, Sigurdur (författare)
Icelandic Heart Association, Kopavogur, Iceland
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Aspelund, Thor (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Fall, Katja, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistcs
Schernhammer, Eva (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA; Department of Epidemiology, Medical University of Vienna, Vienna, Austria
Rider, Jennifer R. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
Launer, Lenore (författare)
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, USA
Harris, Tamara (författare)
Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, Bethesda, USA
Stampfer, Meir J. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
Gudnason, Vilmundur (författare)
Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland
Czeisler, Charles A. (författare)
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, USA; Division of Sleep Medicine, Harvard Medical School, Boston, USA
Lockley, Steven W. (författare)
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, USA Division of Sleep Medicine, Harvard Medical School, Boston, USA
Valdimarsdottir, Unnur A. (författare)
Karolinska Institutet
Mucci, Lorelei A. (författare)
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA
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Icelandic Cancer Society, Reykjavik, Iceland; Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland Department of Epidemiology, Harvard TH. Chan School of Public Health, Boston, USA (creator_code:org_t)
2016-07-26
2016
Engelska.
Ingår i: Journal of Biological Rhythms. - Thousand Oaks, USA : Sage Publications. - 0748-7304 .- 1552-4531. ; 31:5, s. 461-469
Relaterad länk:
https://journals.sag...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The pineal gland produces the hormone melatonin, and its volume may influence melatonin levels. We describe an innovative method for estimating pineal volume in humans and present the association of pineal parenchyma volume with levels of the primary melatonin metabolite, 6-sulfatoxymelatonin. We selected a random sample of 122 older Icelandic men nested within the AGES-Reykjavik cohort and measured their total pineal volume, their parenchyma volume, and the extent of calcification and cysts. For volume estimations we used manual segmentation of magnetic resonance images in the axial plane with simultaneous side-by-side view of the sagittal and coronal plane. We used multivariable adjusted linear regression models to estimate the association of pineal parenchyma volume and baseline characteristics, including 6-sulfatoxymelatonin levels. We used logistic regression to test for differences in first morning urinary 6-sulfatoxymelatonin levels among men with or without cystic or calcified glands. The pineal glands varied in volume, shape, and composition. Cysts were present in 59% of the glands and calcifications in 21%. The mean total pineal volume measured 207 mm(3) (range 65-536 mm(3)) and parenchyma volume 178 mm(3) (range 65-503 mm(3)). In multivariable-adjusted models, pineal parenchyma volume was positively correlated with 6-sulfatoxymelatonin levels (β = 0.52, p < 0.001). Levels of 6-sulfatoxymelatonin did not differ significantly by presence of cysts or calcification. By using an innovative method for pineal assessment, we found pineal parenchyma volume to be positively correlated with 6-sulfatoxymelatonin levels, in line with other recent studies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)

Nyckelord

MRI
circadian
melatonin
pineal
sleep
Fysiologi
Physiology

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