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A generalizable dat...
A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings
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- Baumeister, Hannah (författare)
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Vogel, Jacob W (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups
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- Insel, Philip S (författare)
- University of California, San Francisco
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visa fler...
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- Kleineidam, Luca (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn
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- Wolfsgruber, Steffen (författare)
- University Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Stark, Melina (författare)
- University Hospital Bonn
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- Gellersen, Helena M (författare)
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Yakupov, Renat (författare)
- Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Schmid, Matthias C (författare)
- University Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Lüsebrink, Falk (författare)
- German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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- Brosseron, Frederic (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Ziegler, Gabriel (författare)
- Otto von Guericke University Magdeburg
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- Freiesleben, Silka D (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Preis, Lukas (författare)
- Karolinska Institute
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- Schneider, Luisa-Sophie (författare)
- Karolinska Institute
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- Spruth, Eike J (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Altenstein, Slawek (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Lohse, Andrea (författare)
- Karolinska Institute
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- Fliessbach, Klaus (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Vogt, Ina R (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Bartels, Claudia (författare)
- University Medical Center Göttingen
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- Schott, Björn H (författare)
- University Medical Center Göttingen
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- Rostamzadeh, Ayda (författare)
- University of Cologne
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- Glanz, Wenzel (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Incesoy, Enise I (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Butryn, Michaela (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Janowitz, Daniel (författare)
- Institute for Stroke and Dementia Research (ISD)
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- Rauchmann, Boris-Stephan (författare)
- Ludwig-Maximilian University of Munich,University of Sheffield
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- Kilimann, Ingo (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Goerss, Doreen (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Munk, Matthias H (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Hetzer, Stefan (författare)
- Berlin Center for Advanced Neuroimaging
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- Dechent, Peter (författare)
- University of Göttingen
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- Ewers, Michael (författare)
- Institute for Stroke and Dementia Research (ISD)
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- Scheffler, Klaus (författare)
- University of Tübingen
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- Wuestefeld, Anika (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups
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- Strandberg, Olof (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups
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- van Westen, Danielle (författare)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Mattsson-Carlgren, Niklas (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital
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- Janelidze, Shorena (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups
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- Stomrud, Erik (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Palmqvist, Sebastian (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Spottke, Annika (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Laske, Christoph (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Teipel, Stefan (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Perneczky, Robert (författare)
- German Center for Neurodegenerative Diseases (DZNE), Munich,Ludwig-Maximilian University of Munich
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- Buerger, Katharina (författare)
- Institute for Stroke and Dementia Research (ISD)
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- Schneider, Anja (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Priller, Josef (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Peters, Oliver (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Ramirez, Alfredo (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Wiltfang, Jens (författare)
- University Medical Center Göttingen
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- Heneka, Michael T (författare)
- University of Luxembourg
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- Wagner, Michael (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Düzel, Emrah (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Jessen, Frank (författare)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Berron, David (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE) Magdeburg
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(creator_code:org_t)
- 2024
- 2024
- Engelska 14 s.
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Ingår i: Brain : a journal of neurology. - 1460-2156. ; 147:7, s. 2400-2413
- Relaterad länk:
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http://dx.doi.org/10... (free)
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visa fler...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70.67 ± 6.07 years, 52% females). Participants were cognitively unimpaired (CU; n = 285) or fulfilled diagnostic criteria for subjective cognitive decline (SCD; n = 342), mild cognitive impairment (MCI; n = 118), or dementia of the Alzheimer's type (n = 68). Atrophy subtypes were compared in baseline demographics, fluid AD biomarker levels, the Preclinical Alzheimer Cognitive Composite (PACC-5), as well as episodic memory and executive functioning. PACC-5 trajectories over up to 240 weeks were examined. To test if baseline atrophy subtype and stage predicted clinical trajectories before manifest cognitive impairment, we analysed PACC-5 trajectories and MCI conversion rates of CU and SCD participants. Limbic-predominant and hippocampal-sparing atrophy subtypes were identified. Limbic-predominant atrophy first affected the medial temporal lobes, followed by further temporal and, finally, the remaining cortical regions. At baseline, this subtype was related to older age, more pathological AD biomarker levels, APOE ε4 carriership, and an amnestic cognitive impairment. Hippocampal-sparing atrophy initially occurred outside the temporal lobe with the medial temporal lobe spared up to advanced atrophy stages. This atrophy pattern also affected individuals with positive AD biomarkers and was associated with more generalised cognitive impairment. Limbic-predominant atrophy, in all and in only unimpaired participants, was linked to more negative longitudinal PACC-5 slopes than observed in participants without or with hippocampal-sparing atrophy and increased the risk of MCI conversion. SuStaIn modelling was repeated in a sample from the Swedish BioFINDER-2 cohort. Highly similar atrophy progression patterns and associated cognitive profiles were identified. Cross-cohort model generalizability, both on the subject and group level, were excellent, indicating reliable performance in previously unseen data. The proposed model is a promising tool for capturing heterogeneity among older adults at early at-risk states for AD in applied settings. The implementation of atrophy subtype- and stage-specific end-points may increase the statistical power of pharmacological trials targeting early AD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- disease heterogeneity
- Alzeimer's disease
- Structural MRI
- executive function
- episodic memory
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Baumeister, Hann ...
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Vogel, Jacob W
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Insel, Philip S
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Kleineidam, Luca
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Wolfsgruber, Ste ...
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Stark, Melina
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visa fler...
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Gellersen, Helen ...
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Yakupov, Renat
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Schmid, Matthias ...
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Lüsebrink, Falk
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Brosseron, Frede ...
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Ziegler, Gabriel
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Freiesleben, Sil ...
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Preis, Lukas
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Schneider, Luisa ...
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Spruth, Eike J
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Altenstein, Slaw ...
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Lohse, Andrea
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Fliessbach, Klau ...
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Vogt, Ina R
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Bartels, Claudia
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Schott, Björn H
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Rostamzadeh, Ayd ...
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Glanz, Wenzel
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Incesoy, Enise I
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Butryn, Michaela
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Janowitz, Daniel
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Rauchmann, Boris ...
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Kilimann, Ingo
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Goerss, Doreen
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Munk, Matthias H
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Hetzer, Stefan
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Dechent, Peter
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Ewers, Michael
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Scheffler, Klaus
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Wuestefeld, Anik ...
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Strandberg, Olof
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van Westen, Dani ...
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Mattsson-Carlgre ...
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Janelidze, Shore ...
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Stomrud, Erik
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Palmqvist, Sebas ...
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Spottke, Annika
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Laske, Christoph
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Teipel, Stefan
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Perneczky, Rober ...
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Buerger, Kathari ...
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Schneider, Anja
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Priller, Josef
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Peters, Oliver
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Ramirez, Alfredo
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Wiltfang, Jens
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Heneka, Michael ...
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Wagner, Michael
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Düzel, Emrah
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Jessen, Frank
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Hansson, Oskar
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Berron, David
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
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Brain : a journa ...
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Lunds universitet