SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-198687"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-198687" > Genome-Wide Interac...

Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk

Tian, Yu (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China
Kim, Andre E. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Bien, Stephanie A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
visa fler...
Lin, Yi (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Qu, Conghui (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Harrison, Tabitha A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Carreras-Torres, Robert (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Díez-Obrero, Virginia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Drew, David A. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States
Hidaka, Akihisa (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Huyghe, Jeroen R. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Jordahl, Kristina M. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Morrison, John (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Obón-Santacana, Mireia (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
Ulrich, Cornelia M. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Ose, Jennifer (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Peoples, Anita R. (författare)
Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States
Ruiz-Narvaez, Edward A. (författare)
Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States
Shcherbina, Anna (författare)
Biomedical Informatics Program, Department of Biomedical Data Sciences, Stanford University, CA, Stanford, United States
Stern, Mariana C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Su, Yu-Ru (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Kaiser Permanente Washington Health Research Institute, WA, Seattle, United States
van Duijnhoven, Franzel J B (författare)
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands
Arndt, Volker (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Baurley, James W. (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
Bishop, D Timothy (författare)
Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom
Brenner, Hermann (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany
Buchanan, Daniel D. (författare)
Colorectal Oncogenomics Group, Department of Clinical Pathology, University of Melbourne, VIC, Parkville, Australia; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, VIC, Parkville, Australia; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, VIC, Parkville, Australia
Chan, Andrew T. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Figueiredo, Jane C. (författare)
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Gallinger, Steven (författare)
Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada
Gruber, Stephen B. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Harlid, Sophia, 1978- (författare)
Umeå universitet,Onkologi
Hoffmeister, Michael (författare)
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany
Jenkins, Mark A. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia
Joshi, Amit D. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States
Keku, Temitope O. (författare)
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States
Larsson, Susanna C. (författare)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi
Le Marchand, Loic (författare)
University of Hawaii Cancer Center, HI, Honolulu, United States
Li, Li (författare)
Department of Family Medicine, University of Virginia, VA, Charlottesville, United States
Giles, Graham G. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Milne, Roger L. (författare)
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia
Nan, Hongmei (författare)
Department of Global Health, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States; Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States
Nassir, Rami (författare)
Department of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia
Ogino, Shuji (författare)
Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, MA, Boston, United States; Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States
Budiarto, Arif (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Platz, Elizabeth A. (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
Potter, John D. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
Prentice, Ross L. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Rennert, Gad (författare)
Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel
Sakoda, Lori C. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States
Schoen, Robert E. (författare)
Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
Slattery, Martha L. (författare)
Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States
Thibodeau, Stephen N. (författare)
Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, MN, Rochester, United States
van Guelpen, Bethany (författare)
Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
Visvanathan, Kala (författare)
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
White, Emily (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Wolk, Alicja (författare)
Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi
Woods, Michael O. (författare)
Memorial University of Newfoundland, Discipline of Genetics, St. John's, NL, Canada
Wu, Anna H. (författare)
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Campbell, Peter T. (författare)
Department of Population Science, American Cancer Society, GA, Atlanta, United States
Casey, Graham (författare)
Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States
Conti, David V. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Kundaje, Anshul (författare)
Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States
Lewinger, Juan Pablo (författare)
Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Moreno, Victor (författare)
Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain
Newcomb, Polly A. (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Pardamean, Bens (författare)
Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia
Thomas, Duncan C. (författare)
Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Tsilidis, Konstantinos K. (författare)
Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
Peters, Ulrike (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States
Gauderman, W James (författare)
Division of Biostatistics, Department of Population and Public Health Sciences & USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States
Hsu, Li (författare)
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States
Chang-Claude, Jenny (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Cancer Centre Hamburg (UCCH), University Medical Centre Hamburg-Eppendorf, Hamburg, Germany
visa färre...
 (creator_code:org_t)
2022-05-05
2022
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 114:8, s. 1135-1148
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk. METHODS: We conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants. RESULTS: The use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P < 1.2 × 10-4). CONCLUSION: Genetic variants that modify the association between MHT and CRC risk were identified, offering new insights into pathways of CRC carcinogenesis and potential mechanisms involved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...
Tian, Yu
Kim, Andre E.
Bien, Stephanie ...
Lin, Yi
Qu, Conghui
Harrison, Tabith ...
visa fler...
Carreras-Torres, ...
Díez-Obrero, Vir ...
Dimou, Niki
Drew, David A.
Hidaka, Akihisa
Huyghe, Jeroen R ...
Jordahl, Kristin ...
Morrison, John
Murphy, Neil
Obón-Santacana, ...
Ulrich, Cornelia ...
Ose, Jennifer
Peoples, Anita R ...
Ruiz-Narvaez, Ed ...
Shcherbina, Anna
Stern, Mariana C ...
Su, Yu-Ru
van Duijnhoven, ...
Arndt, Volker
Baurley, James W ...
Berndt, Sonja I.
Bishop, D Timoth ...
Brenner, Hermann
Buchanan, Daniel ...
Chan, Andrew T.
Figueiredo, Jane ...
Gallinger, Steve ...
Gruber, Stephen ...
Harlid, Sophia, ...
Hoffmeister, Mic ...
Jenkins, Mark A.
Joshi, Amit D.
Keku, Temitope O ...
Larsson, Susanna ...
Le Marchand, Loi ...
Li, Li
Giles, Graham G.
Milne, Roger L.
Nan, Hongmei
Nassir, Rami
Ogino, Shuji
Budiarto, Arif
Platz, Elizabeth ...
Potter, John D.
Prentice, Ross L ...
Rennert, Gad
Sakoda, Lori C.
Schoen, Robert E ...
Slattery, Martha ...
Thibodeau, Steph ...
van Guelpen, Bet ...
Visvanathan, Kal ...
White, Emily
Wolk, Alicja
Woods, Michael O ...
Wu, Anna H.
Campbell, Peter ...
Casey, Graham
Conti, David V.
Gunter, Marc J.
Kundaje, Anshul
Lewinger, Juan P ...
Moreno, Victor
Newcomb, Polly A ...
Pardamean, Bens
Thomas, Duncan C ...
Tsilidis, Konsta ...
Peters, Ulrike
Gauderman, W Jam ...
Hsu, Li
Chang-Claude, Je ...
visa färre...
Om ämnet
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Klinisk medicin
och Cancer och onkol ...
MEDICIN OCH HÄLSOVETENSKAP
MEDICIN OCH HÄLS ...
och Medicinska och f ...
och Medicinsk geneti ...
Artiklar i publikationen
Journal of the N ...
Av lärosätet
Umeå universitet
Uppsala universitet
Karolinska Institutet

Sök utanför SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy