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Association of Alcohol-Induced Loss of Consciousness and Overall Alcohol Consumption With Risk for Dementia

Kivimäki, Mika (författare)
Department of Epidemiology and Public Health, University College London, United Kingdom / Clinicum, Faculty of Medicine, University of Helsinki, Finland,UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.;Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
Singh-Manoux, Archana (författare)
Department of Epidemiology and Public Health, University College London, United Kingdom / Epidemiology of Ageing and Neurodegenerative Diseases, INSERM U1153, Université de Paris, France,UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.;Univ Paris, Epidemiol Ageing & Neurodegenerat Dis, INSERM, U1153, Paris, France.
Batty, G. David (författare)
Department of Epidemiology and Public Health, University College London, United Kingdom / Oregon State University School of Biological and Population Health Sciences, Corvallis, Oregon,UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.;Oregon State Univ, Sch Biol & Populat Hlth Sci, Corvallis, OR 97331 USA.
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Sabia, Severine (författare)
Epidemiology of Ageing and Neurodegenerative Diseases, INSERM U1153, Université de Paris, France,Univ Paris, Epidemiol Ageing & Neurodegenerat Dis, INSERM, U1153, Paris, France.
Sommerlad, Andrew (författare)
Division of Psychiatry, University College London, United Kingdom / Camden and Islington NHS Foundation Trust, London, United Kingdom,UCL, Div Psychiat, London, England.;Camden & Islington NHS Fdn Trust, London, England.
Floud, Sarah (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, United Kingdom,Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Jokela, Marcus (författare)
Department of Psychology and Logopedics, University of Helsinki, Finland,Department of Medical Sciences, Uppsala University, Sweden,Univ Helsinki, Dept Psychol & Logoped, Helsinki, Finland.
Vahtera, Jussi (författare)
Department of Public Health, University of Turku, Finland / Centre for Population Health Research, Turku University Hospital, University of Turku, Finland,Univ Turku, Dept Publ Hlth, Turku, Finland.;Univ Turku, Turku Univ Hosp, Ctr Populat Hlth Res, Turku, Finland.
Beydoun, May A. (författare)
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland,NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
Suominen, Sakari B. (författare)
Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Public Health, University of Turku, Finland,Individ och samhälle VIDSOC, Individual and Society,Univ Turku, Dept Publ Hlth, Turku, Finland.;Univ Skövde, Sch Hlth & Educ, Skövde, Sweden.
Koskinen, Aki (författare)
Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland.
Väänänen, Ari (författare)
Finnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland.
Goldberg, Marcel (författare)
Population-Based Epidemiological Cohorts Unit, INSERM UMS 011, Villejuif, France,INSERM, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.
Zins, Marie (författare)
Population-Based Epidemiological Cohorts Unit, INSERM UMS 011, Villejuif, France,INSERM, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.
Alfredsson, Lars (författare)
Karolinska Institutet
Westerholm, Peter (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Knutsson, Anders, 1942- (författare)
Mittuniversitetet,Institutionen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden,Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
Nyberg, Solja T. (författare)
Clinicum, Faculty of Medicine, University of Helsinki, Finland / Finnish Institute of Occupational Health, Helsinki, Finland,Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.;Finnish Inst Occupat Hlth, Helsinki, Finland.
Sipilä, Pyry N. (författare)
Clinicum, Faculty of Medicine, University of Helsinki, Finland,Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
Lindbohm, Joni V. (författare)
Clinicum, Faculty of Medicine, University of Helsinki, Finland,Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
Pentti, Jaana (författare)
Clinicum, Faculty of Medicine, University of Helsinki, Finland / Department of Public Health, University of Turku, Finland / Finnish Institute of Occupational Health, Helsinki, Finland,Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.;Univ Turku, Dept Publ Hlth, Turku, Finland.;Finnish Inst Occupat Hlth, Helsinki, Finland.
Livingston, Gill (författare)
Division of Psychiatry, University College London, United Kingdom / Camden and Islington NHS Foundation Trust, London, United Kingdom,UCL, Div Psychiat, London, England.;Camden & Islington NHS Fdn Trust, London, England.
Ferrie, Jane E. (författare)
Department of Epidemiology and Public Health, University College London, United Kingdom / Bristol Medical School, Population Health Sciences, University of Bristol, United Kingdom,UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
Strandberg, Timo (författare)
Clinicum, Faculty of Medicine, University of Helsinki, Finland / Department of Medicine, Helsinki University Hospital, Finland / Center for Life Course Health Research, University of Oulu, Finland,Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.;Helsinki Univ Hosp, Dept Med, Helsinki, Finland.;Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
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Department of Epidemiology and Public Health, University College London, United Kingdom / Clinicum, Faculty of Medicine, University of Helsinki, Finland UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England;Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland. (creator_code:org_t)
2020-09-09
2020
Engelska.
Ingår i: JAMA Network Open. - : American Medical Association. - 2574-3805. ; 3:9
Relaterad länk:
https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
https://jamanetwork....
https://miun.diva-po... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Importance: Evidence on alcohol consumption as a risk factor for dementia usually relates to overall consumption. The role of alcohol-induced loss of consciousness is uncertain. Objective: To examine the risk of future dementia associated with overall alcohol consumption and alcohol-induced loss of consciousness in a population of current drinkers. Design, Setting, and Participants: Seven cohort studies from the UK, France, Sweden, and Finland (IPD-Work consortium) including 131 415 participants were examined. At baseline (1986-2012), participants were aged 18 to 77 years, reported alcohol consumption, and were free of diagnosed dementia. Dementia was examined during a mean follow-up of 14.4 years (range, 12.3-30.1). Data analysis was conducted from November 17, 2019, to May 23, 2020. Exposures: Self-reported overall consumption and loss of consciousness due to alcohol consumption were assessed at baseline. Two thresholds were used to define heavy overall consumption: greater than 14 units (U) (UK definition) and greater than 21 U (US definition) per week. Main Outcomes and Measures: Dementia and alcohol-related disorders to 2016 were ascertained from linked electronic health records. Results: Of the 131 415 participants (mean [SD] age, 43.0 [10.4] years; 80 344 [61.1%] women), 1081 individuals (0.8%) developed dementia. After adjustment for potential confounders, the hazard ratio (HR) was 1.16 (95% CI, 0.98-1.37) for consuming greater than 14 vs 1 to 14 U of alcohol per week and 1.22 (95% CI, 1.01-1.48) for greater than 21 vs 1 to 21 U/wk. Of the 96 591 participants with data on loss of consciousness, 10 004 individuals (10.4%) reported having lost consciousness due to alcohol consumption in the past 12 months. The association between loss of consciousness and dementia was observed in men (HR, 2.86; 95% CI, 1.77-4.63) and women (HR, 2.09; 95% CI, 1.34-3.25) during the first 10 years of follow-up (HR, 2.72; 95% CI, 1.78-4.15), after excluding the first 10 years of follow-up (HR, 1.86; 95% CI, 1.16-2.99), and for early-onset (<65 y: HR, 2.21; 95% CI, 1.46-3.34) and late-onset (≥65 y: HR, 2.25; 95% CI, 1.38-3.66) dementia, Alzheimer disease (HR, 1.98; 95% CI, 1.28-3.07), and dementia with features of atherosclerotic cardiovascular disease (HR, 4.18; 95% CI, 1.86-9.37). The association with dementia was not explained by 14 other alcohol-related conditions. With moderate drinkers (1-14 U/wk) who had not lost consciousness as the reference group, the HR for dementia was twice as high in participants who reported having lost consciousness, whether their mean weekly consumption was moderate (HR, 2.19; 95% CI, 1.42-3.37) or heavy (HR, 2.36; 95% CI, 1.57-3.54). Conclusions and Relevance: The findings of this study suggest that alcohol-induced loss of consciousness, irrespective of overall alcohol consumption, is associated with a subsequent increase in the risk of dementia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Individual and Society VIDSOC
Individ och samhälle VIDSOC

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