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Plasma IL-5 concent...
Plasma IL-5 concentration and subclinical carotid atherosclerosis
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- Silveira, Angela (author)
- Karolinska Institutet
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McLeod, Olga (author)
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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- Gertow, Karl (author)
- Karolinska Institutet
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- Sennblad, Bengt (author)
- Karolinska Institutet
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Baldassarre, Damiano (author)
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Veglia, Fabrizio (author)
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- Deleskog, Anna (author)
- Karolinska Institutet
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- Persson, Jonas (author)
- Karolinska Institutet
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- Leander, Karin (author)
- Karolinska Institutet
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- Gigante, Bruna (author)
- Karolinska Institutet
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Kauhanen, Jussi (author)
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Rauramaa, Rainer (author)
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Smit, Andries J. (author)
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Mannarino, Elmo (author)
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Giral, Philippe (author)
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- Gustafsson, Sven (author)
- Karolinska Institutet
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- Söderberg, Stefan (author)
- Umeå universitet,Kardiologi
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Ohrvik, John (author)
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Humphries, Steve E. (author)
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Tremoli, Elena (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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- Hamsten, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2015
- 2015
- English.
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In: Atherosclerosis. - : Elsevier BV. - 0021-9150 .- 1879-1484. ; 239:1, s. 125-130
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Abstract
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- Objective: Genetic variants robustly associated with coronary artery disease were reported in the vicinity of the interleukin (IL)-5 locus, and animal studies suggested a protective role for IL-5 in atherosclerosis. Therefore, we set this work to explore IL-5 as a plasma biomarker for early subclinical atherosclerosis, as determined by measures of baseline severity and change over time of carotid intima-media thickness (cIMT).Methods: We used biobank and databases of IMPROVE, a large European prospective cohort study of high-risk individuals (n = 3534) free of clinically overt cardiovascular disease at enrollment, in whom composite and segment-specific measures of cIMT were recorded at baseline and after 15 and 30 months. IL-5 was measured with an immunoassay in plasma samples taken at baseline.Results: IL-5 levels were lower in women than in men, lower in the South than in North of Europe, and showed positive correlations with most established risk factors. IL-5 showed significant inverse relationships with cIMT change over time in the common carotid segment in women, but no significant relationships to baseline cIMT in either men or women.Conclusions: Our results suggest that IL-5 may be part of protective mechanisms operating in early atherosclerosis, at least in women. However, the relationships are weak and whereas IL-5 has been proposed as a potential molecular target to treat allergies, it is difficult to envisage such a scenario in coronary artery disease.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Interleukin-5
- Atherosclerosis
- Cytokines
- Coronary artery disease
- Intima-media thickness
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Silveira, Angela
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McLeod, Olga
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Strawbridge, Ron ...
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Gertow, Karl
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Sennblad, Bengt
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Baldassarre, Dam ...
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show more...
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Veglia, Fabrizio
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Deleskog, Anna
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Persson, Jonas
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Leander, Karin
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Gigante, Bruna
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Kauhanen, Jussi
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Rauramaa, Rainer
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Smit, Andries J.
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Mannarino, Elmo
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Giral, Philippe
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Gustafsson, Sven
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Söderberg, Stefa ...
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Ohrvik, John
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Humphries, Steve ...
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Tremoli, Elena
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de Faire, Ulf
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Hamsten, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Atherosclerosis
- By the university
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Umeå University
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Karolinska Institutet