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Use of temperature ...
Use of temperature changes and pro-inflammatory biomarkers to diagnose bacterial infections in patients with severe cerebral trauma
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- Toros, Andrew (författare)
- Linköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten
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- Grodzinsky, Ewa, 1958- (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för klinisk kemi och farmakologi
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- Karlsson, Nadine, 1965- (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för samhälle och hälsa
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- Nilsson, Martin (författare)
- Region Östergötland, ANOPIVA US
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- Sund-Levander, Märta, 1954- (författare)
- Linköpings universitet,Medicinska fakulteten,Avdelningen för omvårdnad och reproduktiv hälsa,Region Östergötland, Neurokirurgiska kliniken US
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(creator_code:org_t)
- 2022-06-14
- 2022
- Engelska.
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Ingår i: Journal of Neurocritical Care. - : Korean Neurocritical Care Society. - 2508-1349. ; 15:1, s. 21-31
- Relaterad länk:
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BackgroundIn patients undergoing neurosurgeries, inflammation and infection are strongly related; however, inflammation can be present without infection. Midregional proadrenomedullin (MR-proADM) is a relatively new sepsis biomarker that is rarely used clinically. Recently, the concept of DiffTemp was introduced, that is, a >1°C rise from individual normal temperature accompanied by malaise, as a more accurate definition of temperature assessed as fever. The aim of the present study was to examine the importance of C-reactive protein (CRP), white blood cells, procalcitonin, and MR-proADM levels and DiffTemp.MethodsThis prospective, comparative study had a quantitative approach. Forty-two patients, aged >18 years and presenting with severe cerebral trauma were included from a neurosurgical intensive care unit. The outcome variable was infection; group 0, no infection (n=11); group 1, suspected infection (n=15); and, group 2, confirmed infection (n=16). Group assignments were performed using biomarkers, medical records, bacterial cultures, and International Classification of Diseases-10, and by the clinical assessment of criteria for nosocomial infections by a neurosurgeon.ResultsOn comparing groups 1 and 2, MR-proADM and DiffTemp were associated with a higher risk of confirmed infection (odds ratio, 5.41 and 17.14, respectively). Additionally, DiffTemp had a 90.9% specificity in patients with no infection and a 93.8% sensitivity in patients with confirmed infections. CRP and procalcitonin levels were not associated with an increased risk of confirmed infection.ConclusionIncreased levels of MR-proADM were associated with a higher risk of confirmed infection. DiffTemp was associated with a higher risk of having a confirmed infection.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Infection; Fever; DiffTemp; Trauma; Body temperature; Midregional proadrenomedullin
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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