Sökning: WFRF:(Syvänen Ann Christine 1950 ) >
High genetic risk s...
High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus
-
- Reid, Sarah (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Alexsson, Andrei (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Frodlund, Martina (författare)
- Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden
-
visa fler...
-
- Morris, David (författare)
- Department of Medical and Molecular Genetics, King’s College London, London, UK
-
- Sandling, Johanna K. (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Bolin, Karin (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Svenungsson, Elisabet (författare)
- Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Jönsen, Andreas (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Bengtsson, Christine (författare)
- Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
-
- Gunnarsson, Iva (författare)
- Karolinska Institutet,Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Illescas Rodriguez, Vera (författare)
- Karolinska Institute,Rheumatology Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
-
- Bengtsson, Anders (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund SLE Research Group,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Arve, Sabine (författare)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Rheumatology, Department of Clinical Sciences, Lund University, Lund, Sweden
-
- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå University,Umeå universitet,Reumatologi,Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Sweden
-
- Eloranta, Maija-Leena (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Syvänen, Ann-Christine, 1950- (författare)
- Uppsala University,Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
-
- Sjöwall, Christopher (författare)
- Linköping University,Rheumatology/Division of Neuro and Inflammation Sciences, Department of Clinical and Experimental Medicine, Linköping University, Linkoping, Sweden
-
- Vyse, Timothy James (författare)
- Department of Medical and Molecular Genetics, King’s College London, London, UK
-
- Rönnblom, Lars (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
- Leonard, Dag, 1975- (författare)
- Uppsala University,Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
-
visa färre...
-
(creator_code:org_t)
- 2019-12-11
- 2020
- Engelska.
-
Ingår i: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 79:3, s. 363-369
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://ard.bmj.com/...
-
https://umu.diva-por... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci.RESULTS: SLE was more prevalent in the high, compared with the low, GRS-quartile (OR 12.32 (9.53 to 15.71), p=7.9×10-86 and OR 7.48 (6.73 to 8.32), p=2.2×10-304 for the discovery and the replication cohorts, respectively). In the discovery cohort, patients in the high GRS-quartile had a 6-year earlier mean disease onset (HR 1.47 (1.22 to 1.75), p=4.3×10-5), displayed higher prevalence of damage accrual (OR 1.47 (1.06 to 2.04), p=2.0×10-2), renal disorder (OR 2.22 (1.50 to 3.27), p=5.9×10-5), anti-dsDNA (OR 1.83 (1.19 to 2.81), p=6.1×10-3), end-stage renal disease (ESRD) (OR 5.58 (1.50 to 20.79), p=1.0×10-2), proliferative nephritis (OR 2.42 (1.30 to 4.49), p=5.1×10-3), anti-cardiolipin-IgG (OR 1.89 (1.13 to 3.18), p=1.6×10-2), anti-β2-glycoprotein-I-IgG (OR 2.29 (1.29 to 4.06), p=4.8×10-3) and positive lupus anticoagulant test (OR 2.12 (1.16 to 3.89), p=1.5×10-2) compared with patients in the low GRS-quartile. Survival analysis showed earlier onset of the first organ damage (HR 1.51 (1.04 to 2.25), p=3.7×10-2), first cardiovascular event (HR 1.65 (1.03 to 2.64), p=2.6×10-2), nephritis (HR 2.53 (1.72 to 3.71), p=9.6×10-7), ESRD (HR 6.78 (1.78 to 26.86), p=6.5×10-3) and decreased overall survival (HR 1.83 (1.02 to 3.30), p=4.3×10-2) in high to low quartile comparison.CONCLUSIONS: A high GRS is associated with increased risk of organ damage, renal dysfunction and all-cause mortality. Our results indicate that genetic profiling may be useful for predicting outcomes in patients with SLE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- antiphospholipid syndrome
- cardiovascular disease
- gene polymorphism
- lupus nephritis
- systemic lupus erythematosus
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Reid, Sarah
-
Alexsson, Andrei
-
Frodlund, Martin ...
-
Morris, David
-
Sandling, Johann ...
-
Bolin, Karin
-
visa fler...
-
Svenungsson, Eli ...
-
Jönsen, Andreas
-
Bengtsson, Chris ...
-
Gunnarsson, Iva
-
Illescas Rodrigu ...
-
Bengtsson, Ander ...
-
Arve, Sabine
-
Rantapää-Dahlqvi ...
-
Eloranta, Maija- ...
-
Syvänen, Ann-Chr ...
-
Sjöwall, Christo ...
-
Vyse, Timothy Ja ...
-
Rönnblom, Lars
-
Leonard, Dag, 19 ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reumatologi och ...
- Artiklar i publikationen
-
Annals of the Rh ...
- Av lärosätet
-
Uppsala universitet
-
Umeå universitet
-
Lunds universitet
-
Karolinska Institutet