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Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Postmus, Iris (author)
Trompet, Stella (author)
Deshmukh, Harshal A (author)
show more...
Barnes, Michael R (author)
Li, Xiaohui (author)
Warren, Helen R (author)
Chasman, Daniel I (author)
Zhou, Kaixin (author)
Arsenault, Benoit J (author)
Donnelly, Louise A (author)
Wiggins, Kerri L (author)
Avery, Christy L (author)
Griffin, Paula (author)
Feng, QiPing (author)
Taylor, Kent D (author)
Li, Guo (author)
Evans, Daniel S (author)
Smith, Albert V (author)
de Keyser, Catherine E (author)
Johnson, Andrew D (author)
de Craen, Anton J M (author)
Stott, David J (author)
Buckley, Brendan M (author)
Ford, Ian (author)
Westendorp, Rudi G J (author)
Eline Slagboom, P (author)
Sattar, Naveed (author)
Munroe, Patricia B (author)
Sever, Peter (author)
Poulter, Neil (author)
Stanton, Alice (author)
Shields, Denis C (author)
O'Brien, Eoin (author)
Shaw-Hawkins, Sue (author)
Ida Chen, Y-D (author)
Nickerson, Deborah A (author)
Smith, Joshua D (author)
Pierre Dubé, Marie (author)
Matthijs Boekholdt, S (author)
Kees Hovingh, G (author)
Kastelein, John J P (author)
McKeigue, Paul M (author)
Betteridge, John (author)
Neil, Andrew (author)
Durrington, Paul N (author)
Doney, Alex (author)
Carr, Fiona (author)
Morris, Andrew (author)
McCarthy, Mark I (author)
Groop, Leif (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Ahlqvist, Emma (author)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Bis, Joshua C (author)
Rice, Kenneth (author)
Smith, Nicholas L (author)
Lumley, Thomas (author)
Whitsel, Eric A (author)
Stürmer, Til (author)
Boerwinkle, Eric (author)
Ngwa, Julius S (author)
O'Donnell, Christopher J (author)
Vasan, Ramachandran S (author)
Wei, Wei-Qi (author)
Wilke, Russell A (author)
Liu, Ching-Ti (author)
Sun, Fangui (author)
Guo, Xiuqing (author)
Heckbert, Susan R (author)
Post, Wendy (author)
Sotoodehnia, Nona (author)
Arnold, Alice M (author)
Stafford, Jeanette M (author)
Ding, Jingzhong (author)
Herrington, David M (author)
Kritchevsky, Stephen B (author)
Eiriksdottir, Gudny (author)
Launer, Leonore J (author)
Harris, Tamara B (author)
Chu, Audrey Y (author)
Giulianini, Franco (author)
MacFadyen, Jean G (author)
Barratt, Bryan J (author)
Nyberg, Fredrik, 1961 (author)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine
Stricker, Bruno H (author)
Uitterlinden, André G (author)
Hofman, Albert (author)
Rivadeneira, Fernando (author)
Emilsson, Valur (author)
Franco, Oscar H (author)
Ridker, Paul M (author)
Gudnason, Vilmundur (author)
Liu, Yongmei (author)
Denny, Joshua C (author)
Ballantyne, Christie M (author)
Rotter, Jerome I (author)
Adrienne Cupples, L (author)
Psaty, Bruce M (author)
Palmer, Colin N A (author)
Tardif, Jean-Claude (author)
Colhoun, Helen M (author)
Hitman, Graham (author)
Krauss, Ronald M (author)
Wouter Jukema, J (author)
Caulfield, Mark J (author)
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 (creator_code:org_t)
2014-10-28
2014
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 5
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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By the author/editor
Postmus, Iris
Trompet, Stella
Deshmukh, Harsha ...
Barnes, Michael ...
Li, Xiaohui
Warren, Helen R
show more...
Chasman, Daniel ...
Zhou, Kaixin
Arsenault, Benoi ...
Donnelly, Louise ...
Wiggins, Kerri L
Avery, Christy L
Griffin, Paula
Feng, QiPing
Taylor, Kent D
Li, Guo
Evans, Daniel S
Smith, Albert V
de Keyser, Cathe ...
Johnson, Andrew ...
de Craen, Anton ...
Stott, David J
Buckley, Brendan ...
Ford, Ian
Westendorp, Rudi ...
Eline Slagboom, ...
Sattar, Naveed
Munroe, Patricia ...
Sever, Peter
Poulter, Neil
Stanton, Alice
Shields, Denis C
O'Brien, Eoin
Shaw-Hawkins, Su ...
Ida Chen, Y-D
Nickerson, Debor ...
Smith, Joshua D
Pierre Dubé, Mar ...
Matthijs Boekhol ...
Kees Hovingh, G
Kastelein, John ...
McKeigue, Paul M
Betteridge, John
Neil, Andrew
Durrington, Paul ...
Doney, Alex
Carr, Fiona
Morris, Andrew
McCarthy, Mark I
Groop, Leif
Ahlqvist, Emma
Bis, Joshua C
Rice, Kenneth
Smith, Nicholas ...
Lumley, Thomas
Whitsel, Eric A
Stürmer, Til
Boerwinkle, Eric
Ngwa, Julius S
O'Donnell, Chris ...
Vasan, Ramachand ...
Wei, Wei-Qi
Wilke, Russell A
Liu, Ching-Ti
Sun, Fangui
Guo, Xiuqing
Heckbert, Susan ...
Post, Wendy
Sotoodehnia, Non ...
Arnold, Alice M
Stafford, Jeanet ...
Ding, Jingzhong
Herrington, Davi ...
Kritchevsky, Ste ...
Eiriksdottir, Gu ...
Launer, Leonore ...
Harris, Tamara B
Chu, Audrey Y
Giulianini, Fran ...
MacFadyen, Jean ...
Barratt, Bryan J
Nyberg, Fredrik, ...
Stricker, Bruno ...
Uitterlinden, An ...
Hofman, Albert
Rivadeneira, Fer ...
Emilsson, Valur
Franco, Oscar H
Ridker, Paul M
Gudnason, Vilmun ...
Liu, Yongmei
Denny, Joshua C
Ballantyne, Chri ...
Rotter, Jerome I
Adrienne Cupples ...
Psaty, Bruce M
Palmer, Colin N ...
Tardif, Jean-Cla ...
Colhoun, Helen M
Hitman, Graham
Krauss, Ronald M
Wouter Jukema, J
Caulfield, Mark ...
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cardiac and Card ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Pharmacology and ...
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Endocrinology an ...
Articles in the publication
Nature communica ...
By the university
University of Gothenburg
Lund University

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