Development and validation of circulating CA125 prediction models in postmenopausal women

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Development and validation of circulating CA125 prediction models in postmenopausal women

Sasamoto, Naoko (författare): Brigham and Women's Hospital / Harvard Medical School

Babic, Ana (författare): Dana-Farber Cancer Institute

Rosner, Bernard A. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

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Fortner, Renee T. (författare): German Cancer Research Centre

Vitonis, Allison F. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

Yamamoto, Hidemi (författare): Brigham and Women's Hospital / Harvard Medical School

Fichorova, Raina N. (författare): Brigham and Women's Hospital / Harvard Medical School

Titus, Linda J. (författare): Dartmouth College,Norris Cotton Cancer Center

Tjonneland, Anne (författare): Danish Cancer Society,University of Copenhagen

Hansen, Louise (författare): Danish Cancer Society

Kvaskoff, Marina (författare): Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy

Fournier, Agnes (författare): Centre for Research in Epidemiology and Population Health (CESP),Institut Gustave Roussy

Mancini, Francesca Romana (författare): Institut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP)

Boeing, Heiner (författare): German Institute of Human Nutrition

Trichopoulou, Antonia (författare): Hellenic Health Foundation, Athens,National and Kapodistrian University of Athens

Peppa, Eleni (författare): Hellenic Health Foundation, Athens

Karakatsani, Anna (författare): National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens

Palli, Domenico (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Grioni, Sara (författare): Istituto Nazionale dei Tumori

Mattiello, Amalia (författare): University of Naples Federico II

Tumino, Rosario (författare): Civic and M.P Arezzo Hospital

Fiano, Valentina (författare): University of Turin

Onland-Moret, N. Charlotte (författare): University Medical Center Utrecht,Utrecht University

Weiderpass, Elisabete (författare): International Agency for Research on Cancer, World Health Organization

Gram, Inger T. (författare): UiT The Arctic University of Norway, Tromsø

Quiros, J. Ramon (författare): Public Health Directorate

Lujan-Barroso, Leila (författare): Bellvitge University Hospital-IDIBELL,Catalan Institute of Oncology

Sanchez, Maria-Jose (författare): University of Granada,Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)

Colorado-Yohar, Sandra (författare): University of Antioquia,CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council

Barricarte, Aurelio (författare): CIBER Epidemiology and Public Health (CIBERESP)

Amiano, Pilar (författare): CIBER Epidemiology and Public Health (CIBERESP)

Idahl, Annika, 1965- (författare): Umeå University,Umeå universitet,Obstetrik och gynekologi

Lundin, Eva (författare): Umeå University,Umeå universitet,Patologi

Sartor, Hanna (författare): Lund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,Radiology Diagnostics, Malmö,Lund University Research Groups,Skåne University Hospital

Khaw, Kay-Tee (författare): University of Cambridge

Key, Timothy J. (författare): University of Oxford

Muller, David (författare): Imperial College London

Riboli, Elio (författare): Imperial College London

Gunter, Marc (författare): International Agency for Research on Cancer, World Health Organization

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization

Trabert, Britton (författare): National Cancer Institute, USA

Wentzensen, Nicolas (författare): National Cancer Institute, USA

Kaaks, Rudolf (författare): German Cancer Research Centre

Cramer, Daniel W. (författare): Brigham and Women's Hospital / Harvard Medical School,Harvard Medical School

Tworoger, Shelley S. (författare): Harvard University,H. Lee Moffitt Cancer Center & Research Institute

Terry, Kathryn L. (författare): Harvard University,Brigham and Women's Hospital / Harvard Medical School

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(creator_code:org_t)

2019-11-26
2019
Engelska.
Ingår i: Journal of Ovarian Research. - : BioMed Central (BMC). - 1757-2215. ; 12:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://ovarianresea...; http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Background: Cancer Antigen 125 (CA125) is currently the best available ovarian cancer screening biomarker. However, CA125 has been limited by low sensitivity and specificity in part due to normal variation between individuals. Personal characteristics that influence CA125 could be used to improve its performance as screening biomarker.Methods: We developed and validated linear and dichotomous (>= 35 U/mL) circulating CA125 prediction models in postmenopausal women without ovarian cancer who participated in one of five large population-based studies: Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO, n = 26,981), European Prospective Investigation into Cancer and Nutrition (EPIC, n = 861), the Nurses' Health Studies (NHS/NHSII, n = 81), and the New England Case Control Study (NEC, n = 923). The prediction models were developed using stepwise regression in PLCO and validated in EPIC, NHS/NHSII and NEC. Result The linear CA125 prediction model, which included age, race, body mass index (BMI), smoking status and duration, parity, hysterectomy, age at menopause, and duration of hormone therapy (HT), explained 5% of the total variance of CA125. The correlation between measured and predicted CA125 was comparable in PLCO testing dataset (r = 0.18) and external validation datasets (r = 0.14). The dichotomous CA125 prediction model included age, race, BMI, smoking status and duration, hysterectomy, time since menopause, and duration of HT with AUC of 0.64 in PLCO and 0.80 in validation dataset.Conclusions: The linear prediction model explained a small portion of the total variability of CA125, suggesting the need to identify novel predictors of CA125. The dichotomous prediction model showed moderate discriminatory performance which validated well in independent dataset. Our dichotomous model could be valuable in identifying healthy women who may have elevated CA125 levels, which may contribute to reducing false positive tests using CA125 as screening biomarker.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Ovarian cancer
Early detection
CA125
Prediction model
Postmenopausal
CA125
Early detection
Ovarian cancer
Postmenopausal
Prediction model

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Av författaren/redakt...: Sasamoto, Naoko; Babic, Ana; Rosner, Bernard ...; Fortner, Renee T ...; Vitonis, Allison ...; Yamamoto, Hidemi; visa fler...; Fichorova, Raina ...; Titus, Linda J.; Tjonneland, Anne; Hansen, Louise; Kvaskoff, Marina; Fournier, Agnes; Mancini, Frances ...; Boeing, Heiner; Trichopoulou, An ...; Peppa, Eleni; Karakatsani, Ann ...; Palli, Domenico; Grioni, Sara; Mattiello, Amali ...; Tumino, Rosario; Fiano, Valentina; Onland-Moret, N. ...; Weiderpass, Elis ...; Gram, Inger T.; Quiros, J. Ramon; Lujan-Barroso, L ...; Sanchez, Maria-J ...; Colorado-Yohar, ...; Barricarte, Aure ...; Amiano, Pilar; Idahl, Annika, 1 ...; Lundin, Eva; Sartor, Hanna; Khaw, Kay-Tee; Key, Timothy J.; Muller, David; Riboli, Elio; Gunter, Marc; Dossus, Laure; Trabert, Britton; Wentzensen, Nico ...; Kaaks, Rudolf; Cramer, Daniel W ...; Tworoger, Shelle ...; Terry, Kathryn L ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reproduktionsmed ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: Journal of Ovari ...

Av lärosätet: Umeå universitet; Lunds universitet

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