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Biological, clinica...
Biological, clinical and population relevance of 95 loci for blood lipids
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Teslovich, Tanya M. (author)
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Musunuru, Kiran (author)
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Smith, Albert V. (author)
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show more...
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Edmondson, Andrew C. (author)
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Stylianou, Ioannis M. (author)
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Koseki, Masahiro (author)
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Pirruccello, James P. (author)
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Ripatti, Samuli (author)
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Chasman, Daniel I. (author)
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Willer, Cristen J. (author)
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Johansen, Christopher T. (author)
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Fouchier, Sigrid W. (author)
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Isaacs, Aaron (author)
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Peloso, Gina M. (author)
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Barbalic, Maja (author)
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Ricketts, Sally L. (author)
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Bis, Joshua C. (author)
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Aulchenko, Yurii S. (author)
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Thorleifsson, Gudmar (author)
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Feitosa, Mary F. (author)
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Chambers, John (author)
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- Orho-Melander, Marju (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Johnson, Toby (author)
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Li, Xiaohui (author)
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Guo, Xiuqing (author)
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Li, Mingyao (author)
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Cho, Yoon Shin (author)
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Go, Min Jin (author)
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Kim, Young Jin (author)
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Lee, Jong-Young (author)
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Park, Taesung (author)
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- Kim, Kyunga (author)
- Karolinska Institutet
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Sim, Xueling (author)
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Ong, Rick Twee-Hee (author)
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Croteau-Chonka, Damien C. (author)
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Lange, Leslie A. (author)
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Smith, Joshua D. (author)
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Song, Kijoung (author)
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Zhao, Jing Hua (author)
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Yuan, Xin (author)
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Luan, Jian'an (author)
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Lamina, Claudia (author)
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Ziegler, Andreas (author)
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Zhang, Weihua (author)
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Zee, Robert Y. L. (author)
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Wright, Alan F. (author)
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Witteman, Jacqueline C. M. (author)
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Wilson, James F. (author)
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Willemsen, Gonneke (author)
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Wichmann, H. -Erich (author)
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Whitfield, John B. (author)
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Waterworth, Dawn M. (author)
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Wareham, Nicholas J. (author)
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Waeber, Gerard (author)
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Vollenweider, Peter (author)
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Voight, Benjamin F. (author)
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Vitart, Veronique (author)
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Uitterlinden, Andre G. (author)
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Uda, Manuela (author)
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Tuomilehto, Jaakko (author)
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Thompson, John R. (author)
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Tanaka, Toshiko (author)
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Surakka, Ida (author)
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Stringham, Heather M. (author)
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Spector, Tim D. (author)
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Soranzo, Nicole (author)
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Smit, Johannes H. (author)
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Sinisalo, Juha (author)
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Silander, Kaisa (author)
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Sijbrands, Eric J. G. (author)
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Scuteri, Angelo (author)
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Scott, James (author)
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Schlessinger, David (author)
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Sanna, Serena (author)
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Salomaa, Veikko (author)
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Saharinen, Juha (author)
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Sabatti, Chiara (author)
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Ruokonen, Aimo (author)
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Rudan, Igor (author)
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Rose, Lynda M. (author)
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Roberts, Robert (author)
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Rieder, Mark (author)
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Psaty, Bruce M. (author)
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Pramstaller, Peter P. (author)
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Pichler, Irene (author)
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Perola, Markus (author)
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Penninx, Brenda W. J. H. (author)
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- Pedersen, Nancy L. (author)
- Karolinska Institutet
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Pattaro, Cristian (author)
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Parker, Alex N. (author)
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Pare, Guillaume (author)
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Oostra, Ben A. (author)
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O'Donnell, Christopher J. (author)
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Nieminen, Markku S. (author)
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Nickerson, Deborah A. (author)
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Montgomery, Grant W. (author)
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Meitinger, Thomas (author)
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McPherson, Ruth (author)
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McCarthy, Mark I. (author)
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McArdle, Wendy (author)
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Masson, David (author)
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Martin, Nicholas G. (author)
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Marroni, Fabio (author)
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Mangino, Massimo (author)
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Magnusson, Patrik K. E. (author)
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Lucas, Gavin (author)
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Luben, Robert (author)
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Loos, Ruth J. F. (author)
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Lokki, Marja-Liisa (author)
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Lettre, Guillaume (author)
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Langenberg, Claudia (author)
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Launer, Lenore J. (author)
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Lakatta, Edward G. (author)
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Laaksonen, Reijo (author)
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Kyvik, Kirsten O. (author)
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Kronenberg, Florian (author)
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Koenig, Inke R. (author)
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Khaw, Kay-Tee (author)
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Kaprio, Jaakko (author)
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Kaplan, Lee M. (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Jarvelin, Marjo-Riitta (author)
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Janssens, A. Cecile J. W. (author)
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- Ingelsson, Erik (author)
- Karolinska Institutet
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- Igi, Wilmar (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Hovingh, G. Kees (author)
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Hottenga, Jouke-Jan (author)
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Hofman, Albert (author)
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Hicks, Andrew A. (author)
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Hengstenberg, Christian (author)
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Heid, Iris M. (author)
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Hayward, Caroline (author)
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Havulinna, Aki S. (author)
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Hastie, Nicholas D. (author)
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Harris, Tamara B. (author)
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Haritunians, Talin (author)
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Hall, Alistair S. (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Guiducci, Candace (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Gonzalez, Elena (author)
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Gieger, Christian (author)
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Freimer, Nelson B. (author)
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Ferrucci, Luigi (author)
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Erdmann, Jeanette (author)
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Elliott, Paul (author)
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Ejebe, Kenechi G. (author)
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Doering, Angela (author)
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Dominiczak, Anna F. (author)
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Demissie, Serkalem (author)
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Deloukas, Panagiotis (author)
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de Geus, Eco J. C. (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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Crawford, Gabriel (author)
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Collins, Francis S. (author)
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Chen, Yii-der I. (author)
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Caulfield, Mark J. (author)
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Campbell, Harry (author)
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Burtt, Noel P. (author)
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Bonnycastle, Lori L. (author)
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Boomsma, Dorret I. (author)
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Boekholdt, S. Matthijs (author)
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Bergman, Richard N. (author)
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Barroso, Ines (author)
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Bandinelli, Stefania (author)
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Ballantyne, Christie M. (author)
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Assimes, Themistocles L. (author)
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Quertermous, Thomas (author)
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Altshuler, David (author)
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Seielstad, Mark (author)
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Wong, Tien Y. (author)
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Tai, E-Shyong (author)
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Feranil, Alan B. (author)
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Kuzawa, Christopher W. (author)
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Adair, Linda S. (author)
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Taylor, Herman A., Jr. (author)
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Borecki, Ingrid B. (author)
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Gabriel, Stacey B. (author)
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Wilson, James G. (author)
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Holm, Hilma (author)
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Thorsteinsdottir, Unnur (author)
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Gudnason, Vilmundur (author)
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Krauss, Ronald M. (author)
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Mohlke, Karen L. (author)
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Ordovas, Jose M. (author)
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Munroe, Patricia B. (author)
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Kooner, Jaspal S. (author)
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Tall, Alan R. (author)
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Hegele, Robert A. (author)
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Kastelein, John J. P. (author)
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Schadt, Eric E. (author)
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Rotter, Jerome I. (author)
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Boerwinkle, Eric (author)
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Strachan, David P. (author)
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Mooser, Vincent (author)
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Stefansson, Kari (author)
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Reilly, Muredach P. (author)
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Samani, Nilesh J. (author)
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Schunkert, Heribert (author)
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Cupples, L. Adrienne (author)
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Sandhu, Manjinder S. (author)
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Ridker, Paul M. (author)
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Rader, Daniel J. (author)
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van Duijn, Cornelia M. (author)
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Peltonen, Leena (author)
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Abecasis, Goncalo R. (author)
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Boehnke, Michael (author)
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Kathiresan, Sekar (author)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2010
- 2010
- English.
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 466:7307, s. 707-713
- Related links:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nature
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- By the author/editor
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Teslovich, Tanya ...
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Musunuru, Kiran
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Smith, Albert V.
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Edmondson, Andre ...
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Stylianou, Ioann ...
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Koseki, Masahiro
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show more...
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Pirruccello, Jam ...
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Ripatti, Samuli
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Chasman, Daniel ...
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Willer, Cristen ...
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Johansen, Christ ...
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Fouchier, Sigrid ...
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Isaacs, Aaron
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Peloso, Gina M.
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Barbalic, Maja
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Ricketts, Sally ...
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Bis, Joshua C.
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Aulchenko, Yurii ...
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Thorleifsson, Gu ...
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Feitosa, Mary F.
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Chambers, John
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Orho-Melander, M ...
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Melander, Olle
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Johnson, Toby
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Li, Xiaohui
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Guo, Xiuqing
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Li, Mingyao
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Cho, Yoon Shin
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Go, Min Jin
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Kim, Young Jin
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Lee, Jong-Young
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Park, Taesung
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Kim, Kyunga
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Sim, Xueling
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Ong, Rick Twee-H ...
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Croteau-Chonka, ...
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Lange, Leslie A.
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Smith, Joshua D.
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Song, Kijoung
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Zhao, Jing Hua
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Yuan, Xin
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Luan, Jian'an
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Lamina, Claudia
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Ziegler, Andreas
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Zhang, Weihua
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Zee, Robert Y. L ...
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Wright, Alan F.
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Witteman, Jacque ...
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Wilson, James F.
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Willemsen, Gonne ...
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Wichmann, H. -Er ...
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Whitfield, John ...
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Waterworth, Dawn ...
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Wareham, Nichola ...
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Waeber, Gerard
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Vollenweider, Pe ...
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Voight, Benjamin ...
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Vitart, Veroniqu ...
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Uitterlinden, An ...
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Uda, Manuela
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Tuomilehto, Jaak ...
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Thompson, John R ...
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Tanaka, Toshiko
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Surakka, Ida
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Stringham, Heath ...
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Spector, Tim D.
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Soranzo, Nicole
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Smit, Johannes H ...
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Sinisalo, Juha
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Silander, Kaisa
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Sijbrands, Eric ...
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Scuteri, Angelo
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Scott, James
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Schlessinger, Da ...
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Sanna, Serena
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Salomaa, Veikko
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Saharinen, Juha
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Sabatti, Chiara
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Ruokonen, Aimo
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Rudan, Igor
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Rose, Lynda M.
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Roberts, Robert
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Rieder, Mark
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Psaty, Bruce M.
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Pramstaller, Pet ...
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Pichler, Irene
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Perola, Markus
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Penninx, Brenda ...
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Pedersen, Nancy ...
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Pattaro, Cristia ...
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Parker, Alex N.
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Pare, Guillaume
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Oostra, Ben A.
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O'Donnell, Chris ...
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Nieminen, Markku ...
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Nickerson, Debor ...
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Montgomery, Gran ...
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Meitinger, Thoma ...
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McPherson, Ruth
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McCarthy, Mark I ...
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McArdle, Wendy
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Masson, David
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Martin, Nicholas ...
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Marroni, Fabio
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Mangino, Massimo
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Magnusson, Patri ...
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Lucas, Gavin
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Luben, Robert
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Loos, Ruth J. F.
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Lokki, Marja-Lii ...
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Lettre, Guillaum ...
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Langenberg, Clau ...
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Launer, Lenore J ...
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Lakatta, Edward ...
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Laaksonen, Reijo
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Kyvik, Kirsten O ...
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Kronenberg, Flor ...
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Koenig, Inke R.
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Khaw, Kay-Tee
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Kaprio, Jaakko
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Kaplan, Lee M.
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Johansson, Åsa
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Jarvelin, Marjo- ...
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Janssens, A. Cec ...
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Ingelsson, Erik
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Igi, Wilmar
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Hovingh, G. Kees
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Hottenga, Jouke- ...
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Hofman, Albert
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Hicks, Andrew A.
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Hengstenberg, Ch ...
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Heid, Iris M.
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Hayward, Carolin ...
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Havulinna, Aki S ...
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Hastie, Nicholas ...
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Harris, Tamara B ...
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Haritunians, Tal ...
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Hall, Alistair S ...
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Gyllensten, Ulf
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Guiducci, Candac ...
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Groop, Leif
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Gonzalez, Elena
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Gieger, Christia ...
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Freimer, Nelson ...
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Ferrucci, Luigi
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Erdmann, Jeanett ...
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Elliott, Paul
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Ejebe, Kenechi G ...
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Doering, Angela
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Dominiczak, Anna ...
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Demissie, Serkal ...
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Deloukas, Panagi ...
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de Geus, Eco J. ...
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de Faire, Ulf
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Crawford, Gabrie ...
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Collins, Francis ...
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Chen, Yii-der I.
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Caulfield, Mark ...
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Campbell, Harry
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Burtt, Noel P.
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Bonnycastle, Lor ...
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Boomsma, Dorret ...
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Boekholdt, S. Ma ...
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Bergman, Richard ...
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Barroso, Ines
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Bandinelli, Stef ...
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Ballantyne, Chri ...
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Assimes, Themist ...
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Quertermous, Tho ...
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Altshuler, David
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Seielstad, Mark
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Wong, Tien Y.
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Tai, E-Shyong
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Feranil, Alan B.
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Kuzawa, Christop ...
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Adair, Linda S.
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Taylor, Herman A ...
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Borecki, Ingrid ...
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Gabriel, Stacey ...
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Wilson, James G.
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Holm, Hilma
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Thorsteinsdottir ...
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Gudnason, Vilmun ...
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Krauss, Ronald M ...
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Mohlke, Karen L.
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Ordovas, Jose M.
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Munroe, Patricia ...
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Kooner, Jaspal S ...
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Tall, Alan R.
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Hegele, Robert A ...
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Kastelein, John ...
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Schadt, Eric E.
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Rotter, Jerome I ...
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Boerwinkle, Eric
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Strachan, David ...
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Mooser, Vincent
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Stefansson, Kari
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Reilly, Muredach ...
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Samani, Nilesh J ...
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Schunkert, Herib ...
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Cupples, L. Adri ...
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Sandhu, Manjinde ...
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Ridker, Paul M.
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Rader, Daniel J.
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van Duijn, Corne ...
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Peltonen, Leena
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Abecasis, Goncal ...
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Boehnke, Michael
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Kathiresan, Seka ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Nature
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet