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Evening chronotype ...
Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study
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- Baldanzi, Gabriel (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Tove Fall
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- Hammar, Ulf (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Tove Fall
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- Fall, Tove, 1979- (författare)
- Uppsala University,Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Tove Fall
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- Lindberg, Eva (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning
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- Lind, Lars (författare)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Elmståhl, Sölve (författare)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Skåne University Hospital
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- Theorell-Haglöw, Jenny (författare)
- Uppsala University,Uppsala universitet,Lung- allergi- och sömnforskning,Molekylär epidemiologi
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(creator_code:org_t)
- 2021-09-04
- 2022
- Engelska.
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Ingår i: Sleep. - : Oxford University Press. - 0161-8105 .- 1550-9109. ; 45:2
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://academic.oup...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Study objectives: Individuals with evening chronotype have a higher risk of cardiovascular and metabolic disorders, although the underlying mechanisms are not well understood. In a population- based cohort, we aimed to investigate the association between chronotype and 242 circulating proteins from three panels of established or candidate biomarkers of cardiometabolic processes. Methods: In 2,471 participants (49.7% men, mean age 61.2±8.4 SD years) from the EpiHealth cohort, circulating proteins were analyzed with a multiplex proximity extension technique. Participants self- reported their chronotype on a five-level scale from extreme morning to extreme evening chronotype. With the intermediate chronotype set as the reference, each protein was added as the dependent variable in a series of linear regression models adjusted for confounders. Next, the chronotype coefficients were jointly tested and the resulting p-values adjusted for multiple testing using false discovery rate (5%). For the associations identified, we then analyzed the marginal effect of each chronotype category. Results: We identified 17 proteins associated with chronotype. Evening chronotype was positively associated with proteins previously linked to insulin resistance and cardiovascular risk, namely retinoic acid receptor protein 2, fatty acid-binding protein adipocyte, tissue-type plasminogen activator, and plasminogen activator inhibitor 1 (PAI-1). Additionally, PAI-1 was inversely associated with the extreme morning chronotype. Conclusions: In this population-based study, proteins previously related with cardiometabolic risk were elevated in the evening chronotypes. These results may guide future research in the relation between chronotype and cardiometabolic disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- chronotype
- sleep habits
- proteomics
- cohort studies
- cardiovascular diseases
- metabolic diseases
- cardiovascular diseases
- chronotype
- cohort studies
- metabolic diseases
- proteomics
- sleep habits
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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