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Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Bellenguez, Celine (author)
Bevan, Steve (author)
Gschwendtner, Andreas (author)
show more...
Spencer, Chris C. A. (author)
Burgess, Annette I. (author)
Pirinen, Matti (author)
Jackson, Caroline A. (author)
Traylor, Matthew (author)
Strange, Amy (author)
Su, Zhan (author)
Band, Gavin (author)
Syme, Paul D. (author)
Malik, Rainer (author)
Pera, Joanna (author)
Norrving, Bo (author)
Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Lemmens, Robin (author)
Freeman, Colin (author)
Schanz, Renata (author)
James, Tom (author)
Poole, Deborah (author)
Murphy, Lee (author)
Segal, Helen (author)
Cortellini, Lynelle (author)
Cheng, Yu-Ching (author)
Woo, Daniel (author)
Nalls, Michael A. (author)
Mueller-Myhsok, Bertram (author)
Meisinger, Christa (author)
Seedorf, Udo (author)
Ross-Adams, Helen (author)
Boonen, Steven (author)
Wloch-Kopec, Dorota (author)
Valant, Valerie (author)
Slark, Julia (author)
Furie, Karen (author)
Delavaran, Hossein (author)
Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Langford, Cordelia (author)
Deloukas, Panos (author)
Edkins, Sarah (author)
Hunt, Sarah (author)
Gray, Emma (author)
Dronov, Serge (author)
Peltonen, Leena (author)
Gretarsdottir, Solveig (author)
Thorleifsson, Gudmar (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
Boncoraglio, Giorgio B. (author)
Parati, Eugenio A. (author)
Attia, John (author)
Holliday, Elizabeth (author)
Levi, Chris (author)
Franzosi, Maria-Grazia (author)
Goel, Anuj (author)
Helgadottir, Anna (author)
Blackwell, Jenefer M. (author)
Bramon, Elvira (author)
Brown, Matthew A. (author)
Casas, Juan P. (author)
Corvin, Aiden (author)
Duncanson, Audrey (author)
Jankowski, Janusz (author)
Mathew, Christopher G. (author)
Palmer, Colin N. A. (author)
Plomin, Robert (author)
Rautanen, Anna (author)
Sawcer, Stephen J. (author)
Trembath, Richard C. (author)
Viswanathan, Ananth C. (author)
Wood, Nicholas W. (author)
Worrall, Bradford B. (author)
Kittner, Steven J. (author)
Mitchell, Braxton D. (author)
Kissela, Brett (author)
Meschia, James F. (author)
Thijs, Vincent (author)
Lindgren, Arne (author)
Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
Macleod, Mary Joan (author)
Slowik, Agnieszka (author)
Walters, Matthew (author)
Rosand, Jonathan (author)
Sharma, Pankaj (author)
Farrall, Martin (author)
Sudlow, Cathie L. M. (author)
Rothwell, Peter M. (author)
Dichgans, Martin (author)
Donnelly, Peter (author)
Markus, Hugh S. (author)
show less...
 (creator_code:org_t)
2012-02-05
2012
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:3, s. 141-328
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Genetic factors have been implicated in stroke risk, but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) for ischemic stroke and its subtypes in 3,548 affected individuals and 5,972 controls, all of European ancestry. Replication of potential signals was performed in 5,859 affected individuals and 6,281 controls. We replicated previous associations for cardioembolic stroke near PITX2 and ZFHX3 and for large vessel stroke at a 9p21 locus. We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 x 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57). All four loci exhibited evidence for heterogeneity of effect across the stroke subtypes, with some and possibly all affecting risk for only one subtype. This suggests distinct genetic architectures for different stroke subtypes.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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By the author/editor
Bellenguez, Celi ...
Bevan, Steve
Gschwendtner, An ...
Spencer, Chris C ...
Burgess, Annette ...
Pirinen, Matti
show more...
Jackson, Carolin ...
Traylor, Matthew
Strange, Amy
Su, Zhan
Band, Gavin
Syme, Paul D.
Malik, Rainer
Pera, Joanna
Norrving, Bo
Lemmens, Robin
Freeman, Colin
Schanz, Renata
James, Tom
Poole, Deborah
Murphy, Lee
Segal, Helen
Cortellini, Lyne ...
Cheng, Yu-Ching
Woo, Daniel
Nalls, Michael A ...
Mueller-Myhsok, ...
Meisinger, Chris ...
Seedorf, Udo
Ross-Adams, Hele ...
Boonen, Steven
Wloch-Kopec, Dor ...
Valant, Valerie
Slark, Julia
Furie, Karen
Delavaran, Hosse ...
Langford, Cordel ...
Deloukas, Panos
Edkins, Sarah
Hunt, Sarah
Gray, Emma
Dronov, Serge
Peltonen, Leena
Gretarsdottir, S ...
Thorleifsson, Gu ...
Thorsteinsdottir ...
Stefansson, Kari
Boncoraglio, Gio ...
Parati, Eugenio ...
Attia, John
Holliday, Elizab ...
Levi, Chris
Franzosi, Maria- ...
Goel, Anuj
Helgadottir, Ann ...
Blackwell, Jenef ...
Bramon, Elvira
Brown, Matthew A ...
Casas, Juan P.
Corvin, Aiden
Duncanson, Audre ...
Jankowski, Janus ...
Mathew, Christop ...
Palmer, Colin N. ...
Plomin, Robert
Rautanen, Anna
Sawcer, Stephen ...
Trembath, Richar ...
Viswanathan, Ana ...
Wood, Nicholas W ...
Worrall, Bradfor ...
Kittner, Steven ...
Mitchell, Braxto ...
Kissela, Brett
Meschia, James F ...
Thijs, Vincent
Lindgren, Arne
Macleod, Mary Jo ...
Slowik, Agnieszk ...
Walters, Matthew
Rosand, Jonathan
Sharma, Pankaj
Farrall, Martin
Sudlow, Cathie L ...
Rothwell, Peter ...
Dichgans, Martin
Donnelly, Peter
Markus, Hugh S.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Neurology
Articles in the publication
Nature Genetics
By the university
Lund University

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