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Exocrine pancreatic...
Exocrine pancreatic function is preserved in systemic sclerosis
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- Bozovic, Gracijela (författare)
- Skåne University Hospital
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- Pullerits, Rille, 1969 (författare)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Sahlgrenska University Hospital
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- Stahl, A. (författare)
- Sahlgrenska University Hospital
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- Ydstrom, K. (författare)
- Skåne University Hospital
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- Wenger, Daniel (författare)
- Lund University,Lunds universitet,Lund OsteoArthritis Division - Höftsjukdomar från vaggan till protesen,Forskargrupper vid Lunds universitet,Lund OsteoArthritis Division - Hip diseases from the cradle to the prosthesis,Lund University Research Groups
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- Marsal, Jan (författare)
- Lund University,Lunds universitet,Gastro,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Thulin, P. (författare)
- Sahlgrenska University Hospital
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- Andréasson, Kristofer (författare)
- Lund University,Lunds universitet,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Lund Systemic Sclerosis Research Group,Lund University Research Groups
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(creator_code:org_t)
- 2019-02-12
- 2019
- Engelska.
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Ingår i: Arthritis Research & Therapy. - : Springer Science and Business Media LLC. - 1478-6354 .- 1478-6362. ; 21
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Systemic sclerosis (SSc) has been suggested to cause exocrine pancreatic dysfunction. However, a case-control-based autopsy study failed to associate systemic sclerosis with any pancreatic histopathology. The primary objective of this study was to examine the exocrine pancreatic function in consecutive SSc patients in relation to an age- and sex-matched control group. A secondary objective was to relate exocrine pancreatic function to radiological, laboratory, and clinical SSc characteristics. Methods: One hundred twelve consecutive patients fulfilling the 2013 American Congress of Rheumatology/European League Against Rheumatism criteria for SSc and 52 control subjects were matched for sex and age. Exocrine pancreatic function was assessed by ELISA-based measurement of fecal elastase, and levels <= 200g/g were considered pathological, i.e., representing exocrine pancreatic insufficiency. Patients were characterized regarding SSc manifestations including gastrointestinal and hepatobiliary function, by use of laboratory and clinical examinations. Pancreas parenchyma characteristics were evaluated by high-resolution computer tomography (HRCT). Results: A similar proportion of subjects exhibited pathological levels of fecal elastase among SSc patients (6/112; 5.4%) and control subjects (3/52; 5.8%). Patients with fecal elastase <= 200g/g did not differ from other SSc patients with respect to laboratory and clinical characteristics, including malnutrition. SSc subjects with low levels of fecal elastase displayed significantly lower pancreas attenuation on HRCT examinations compared to the control subjects. Conclusions: In this study encompassing 112 consecutive SSc patients and 52 matched control subjects, we were unable to associate systemic sclerosis with clinically significant exocrine pancreatic dysfunction.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Pancreas
- Systemic sclerosis
- Fecal elastase
- Malnutrition
- fecal elastase-1
- scleroderma
- classification
- involvement
- criteria
- disease
- Rheumatology
- udamore hh
- 1968
- american journal of gastroenterology
- v49
- p193
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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