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Dietary intake and plasma phospholipid concentrations of saturated, monounsaturated and trans fatty acids and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Aglago, Elom K. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Huybrechts, Inge (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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Nicolas, Geneviève (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Casagrande, Corinne (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France,Department of Public Health, Aarhus University, Aarhus, Denmark
Fedirko, Veronika (författare)
Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, GA, Atlanta, United States
Weiderpass, Elisabete (författare)
Office of the Director, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Rothwell, Joseph A. (författare)
Stabilite genetique et oncogenese,Versailles Saint-Quentin-en-Yvelines University,CESP, Faculté de médecine—Université Paris-Saclay, UVSQ, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
Dahm, Christina C. (författare)
Aarhus University
Olsen, Anja (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Aarhus, Aarhus, Denmark,Aarhus University
Tjønneland, Anne (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark,Danish Cancer Society
Kaaks, Rudolf (författare)
German Cancer Research Center (DKFZ), Foundation under Public Law, Heidelberg, Germany
Katzke, Verena (författare)
German Cancer Research Center (DKFZ), Foundation under Public Law, Heidelberg, Germany
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany,German Institute of Human Nutrition
Masala, Giovanna (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network –ISPRO, Florence, Italy
Agnoli, Claudia (författare)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
Panico, Salvatore (författare)
Dipartimento di Medicina Clinica e Chirurgia Federico II University, Naples, Italy
Tumino, Rosario (författare)
Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
Bueno-de-Mesquita, Bas H. (författare)
Former senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
Derksen, Jeroen W.G. (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Skeie, Guri (författare)
UiT The Arctic University of Norway, Tromsø,Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Gram, Inger Torhild (författare)
UiT The Arctic University of Norway, Tromsø,Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Brustad, Magritt (författare)
UiT The Arctic University of Norway, Tromsø,Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
Jakszyn, Paula (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain,Ramon Llull University
Sánchez, Maria Jose (författare)
Andalusian School Of Public Health (EASP),Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Amiano, Pilar (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain
Huerta, José María (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Ericson, Ulrika (författare)
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden
Wennberg, Maria, 1974- (författare)
Umeå universitet,Umeå University,Avdelningen för hållbar hälsa
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Heath, Alicia K. (författare)
School of Public Health, Imperial College London, London, United Kingdom
Jenab, Mazda (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Chajes, Veronique (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), World Health Organization, Lyon, France
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 (creator_code:org_t)
2021-05-14
2021
Engelska 18 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 149:4, s. 865-882
Relaterad länk:
http://dx.doi.org/10...
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https://lup.lub.lu.s...
https://doi.org/10.1...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Epidemiologic studies examining the association between specific fatty acids and colorectal cancer (CRC) risk are inconclusive. We investigated the association between dietary estimates and plasma levels of individual and total saturated (SFA), monounsaturated (MUFA), industrial-processed trans (iTFA), and ruminant-sourced trans (rTFA) fatty acids, and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Baseline fatty acid intakes were estimated in 450 112 participants (6162 developed CRC, median follow-up = 15 years). In a nested case-control study, plasma phospholipid fatty acids were determined by gas chromatography in 433 colon cancer cases and 433 matched controls. Multivariable-adjusted hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were computed using Cox and conditional logistic regression, respectively. Dietary total SFA (highest vs lowest quintile, HRQ5vsQ1 = 0.80; 95%CI:0.69-0.92), myristic acid (HRQ5vsQ1 = 0.83, 95%CI:0.74-0.93) and palmitic acid (HRQ5vsQ1 = 0.81, 95%CI:0.70-0.93) were inversely associated with CRC risk. Plasma myristic acid was also inversely associated with colon cancer risk (highest vs lowest quartile, ORQ4vsQ1 = 0.51; 95%CI:0.32-0.83), whereas a borderline positive association was found for plasma stearic acid (ORQ4vsQ1 = 1.63; 95%CI:1.00-2.64). Dietary total MUFA was inversely associated with colon cancer (per 1-SD increment, HR1-SD = 0.92, 95%CI: 0.85-0.98), but not rectal cancer (HR1-SD = 1.04, 95%CI:0.95-1.15, Pheterogeneity = 0.027). Dietary iTFA, and particularly elaidic acid, was positively associated with rectal cancer (HR1-SD = 1.07, 95%CI:1.02-1.13). Our results suggest that total and individual saturated fatty acids and fatty acids of industrial origin may be relevant to the aetiology of CRC. Both dietary and plasma myristic acid levels were inversely associated with colon cancer risk, which warrants further investigation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

biomarker
colorectal cancer
dietary intake
fatty acids
biomarker

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art (ämneskategori)
ref (ämneskategori)

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