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Plasma 25-hydroxyvi...
Plasma 25-hydroxyvitamin D concentration and lymphoma risk: results of the European Prospective Investigation into Cancer and Nutrition
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Luczynska, Anna (author)
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Kaaks, Rudolf (author)
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Rohrmann, Sabine (author)
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show more...
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Becker, Susen (author)
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Linseisen, Jakob (author)
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Buijsse, Brian (author)
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Overvad, Kim (author)
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Trichopoulou, Antonia (author)
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Valanou, Elisavet (author)
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Barmpitsioti, Antonia (author)
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Masala, Giovanna (author)
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Agnoli, Claudia (author)
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Tumino, Rosario (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H. Bas (author)
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van Duijnhoven, Franzel J. B. (author)
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Peeters, Petra H. M. (author)
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Vernieulen, Roel (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Brustad, Magritt (author)
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Skeie, Guri (author)
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Gonzalez, Carlos A. (author)
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Jakszyn, Paula (author)
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Ramon Quiros, J. (author)
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Sanchez, Maria-Jose (author)
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Huerta, Jose-Maria (author)
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Ardanaz, Eva (author)
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- Melin, Beatrice (author)
- Umeå universitet,Onkologi
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- Johansson, Ann Sofie (author)
- Umeå universitet,Onkologi
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- Almquist, Martin (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Malm, Johan (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups
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Khaw, Kay-Tee (author)
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Wareham, Nick (author)
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Travis, Ruth C. (author)
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Fedirko, Veronika (author)
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Romieu, Isabelle (author)
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Jenab, Mazda (author)
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Gallo, Valentina (author)
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Riboli, Elio (author)
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Vineis, Paolo (author)
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Nieters, Alexandra (author)
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(creator_code:org_t)
- Rockville Pike, Bethesda, MD, USA : Elsevier BV, 2013
- 2013
- English.
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In: American Journal of Clinical Nutrition. - Rockville Pike, Bethesda, MD, USA : Elsevier BV. - 1938-3207 .- 0002-9165. ; 98:3, s. 827-838
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http://dx.doi.org/10...
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https://academic.oup...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
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- Background: The relation between vitamin D status and lymphoma risk is inconclusive. Objective: We examined the association between prediagnostic plasma 25-hydroxyvitamin D [25(OH)D] and lymphoid cancer risk. Design: We conducted a study nested within the European Prospective Investigation into Cancer and Nutrition cohort of 1127 lymphoma cases and 1127 matched controls with a mean follow-up time of 7.1 y. Conditional logistic regression was used to estimate multivariable-adjusted incidence rate ratios of lymphoma risk in relation to plasma 25(OH)D. Season-standardized and season-specific 25(OH)D quartiles were used. We also analyzed 25(OH)D as a continuous variable and used predefined cutoffs. Results: No statistically significant association between plasma 25(OH)D and overall lymphoid cancer risk was observed. A positive association for B-cell non-Hodgkin lymphoma was noted only in those with a diagnosis made during the first 2 y of follow-up (P-heterogeneity = 0.03), which suggests the possibility of reverse causality. Further analysis restricted to participants with >= 2y of follow-up time showed a significant association between 25(OH)D and chronic lymphocytic leukemia (CLL) (n = 161): adjusted incidence rate ratios were 0.40 (95% CI: 0.18, 0.90; P-trend = 0.05) and 0.31 (95% CI: 0.13, 0.76; P-trend = 0.03) for the top compared with the bottom season-standardized and season-specific quartiles, respectively. Data on dietary vitamin D intake provided further support for the observed association (incidence rate ratio: 0.33; 95% CI = 0.12, 0.89; P-trend = 0.006). Conclusions: Our findings do not support a protective role of high 25(OH)D concentration in lymphoid cancers overall. However, they suggest that higher concentrations of 25(OH)D are associated with a reduced risk of CLL.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Luczynska, Anna
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Kaaks, Rudolf
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Rohrmann, Sabine
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Becker, Susen
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Linseisen, Jakob
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Buijsse, Brian
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show more...
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Overvad, Kim
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Trichopoulou, An ...
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Valanou, Elisave ...
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Barmpitsioti, An ...
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Masala, Giovanna
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Agnoli, Claudia
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Tumino, Rosario
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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van Duijnhoven, ...
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Peeters, Petra H ...
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Vernieulen, Roel
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Weiderpass, Elis ...
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Brustad, Magritt
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Skeie, Guri
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Gonzalez, Carlos ...
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Jakszyn, Paula
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Ramon Quiros, J.
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Sanchez, Maria-J ...
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Huerta, Jose-Mar ...
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Ardanaz, Eva
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Melin, Beatrice
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Johansson, Ann S ...
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Almquist, Martin
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Malm, Johan
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Khaw, Kay-Tee
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Wareham, Nick
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Travis, Ruth C.
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Fedirko, Veronik ...
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Romieu, Isabelle
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Jenab, Mazda
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Gallo, Valentina
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Riboli, Elio
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Vineis, Paolo
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Nieters, Alexand ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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American Journal ...
- By the university
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Lund University
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Karolinska Institutet
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Umeå University