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Cancer risk in the ...
Cancer risk in the siblings of individuals with major birth defects : a large Nordic population-based case-control study
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- Daltveit, Dagrun Slettebo (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Haukeland Hosp, Surg Clin, Norwegian Qual Registry Cleft Lip & Palate, Bergen, Norway.;Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway.
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- Klungsoyr, Kari (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway.
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- Engeland, Anders (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway.
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- Ekbom, Anders (författare)
- Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Gissler, Mika (författare)
- Karolinska Institutet,Finnish Inst Hlth & Welf THL, Dept Knowledge Brokers, Helsinki, Finland.;Reg Stockholm, Acad Primary Hlth Care Ctr, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
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- Glimelius, Ingrid, 1975- (författare)
- Karolinska Institutet,Uppsala universitet,Cancerprecisionsmedicin,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Grotmol, Tom (författare)
- Canc Registry Norway, Oslo, Norway.
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- Madanat-Harjuoja, Laura (författare)
- Canc Soc Finland, Finnish Canc Registry, Helsinki, Finland.;Dana Farber Canc Inst, Boston Childrens Canc & Blood Disorders Ctr, Boston, MA USA.
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- Ording, Anne Gulbech (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark.;Aarhus Univ, Aarhus, Denmark.
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- Sorensen, Henrik Toft (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark.;Aarhus Univ, Aarhus, Denmark.
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- Troisi, Rebecca (författare)
- NCI, Trans Div Res Program, Div Canc Epidemiol & Genet, Rockville, MD USA.
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- Bjorge, Tone (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway.
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Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway;Haukeland Hosp, Surg Clin, Norwegian Qual Registry Cleft Lip & Palate, Bergen, Norway.;Univ Bergen, Dept Global Publ Hlth & Primary Care, Pb 7804, N-5020 Bergen, Norway. Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway. (creator_code:org_t)
- Oxford University Press, 2023
- 2023
- Engelska.
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Ingår i: International Journal of Epidemiology. - : Oxford University Press. - 0300-5771 .- 1464-3685. ; 52:6, s. 1826-1835
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Individuals with major birth defects are at increased risk of developing cancer, indicating a common aetiology. However, whether the siblings of individuals with birth defects are also at an increased risk of cancer is unclear.Methods: We used nationwide health registries in four Nordic countries and conducted a nested case-control study. We included 40 538 cancer cases (aged 0-46 years) and 481 945 population controls (matched by birth year and country), born between 1967 and 2014. The relative risk of cancer among individuals whose siblings had birth defects was computed with odds ratios (OR) and 95% confidence intervals (CIs), using logistic regression models.Results: In the total study population (aged 0-46 years), we observed no overall difference in cancer risk between individuals whose siblings had birth defects and those who had unaffected siblings (OR 1.02; 95% CI 0.97-1.08); however, the risk of lymphoid and haematopoietic malignancies was elevated (1.16; 1.05-1.28). The overall risk of childhood cancer (0-19 years) was increased for siblings of individuals who had birth defects (1.09; 1.00-1.19), which was mainly driven by lymphoma (1.35; 1.09-1.66), neuroblastoma (1.51; 1.11-2.05) and renal carcinoma (5.03; 1.73-14.6). The risk of cancer also increased with the number of siblings with birth defects (P-trend = 0.008).Conclusion: Overall risk of cancer among individuals (aged 0-46 years) whose siblings had birth defects was not elevated, but the risk of childhood cancer (ages 0-19 years) was increased. Our novel findings are consistent with the common aetiologies of birth defects and cancer, such as shared genetic predisposition and environmental factors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Neoplasms
- abnormalities
- epidemiology
- aetiology
- risk
- sibling
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- art (ämneskategori)
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Daltveit, Dagrun ...
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Klungsoyr, Kari
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Engeland, Anders
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Ekbom, Anders
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Gissler, Mika
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Glimelius, Ingri ...
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Grotmol, Tom
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Madanat-Harjuoja ...
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Ording, Anne Gul ...
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Sorensen, Henrik ...
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Troisi, Rebecca
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Bjorge, Tone
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