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Sökning: onr:"swepub:oai:DiVA.org:umu-199386" > Cigarette Smoking a...

Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses

Dimou, Niki (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Omiyale, Wemimo (författare)
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Biessy, Carine (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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Viallon, Vivian (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Kaaks, Rudolf (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
O'Mara, Tracy A. (författare)
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
Aglago, Elom K. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Ardanaz, Eva (författare)
Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain
Bergmann, Manuela M. (författare)
German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
Bondonno, Nicola P. (författare)
Danish Cancer Society Research Center, Copenhagen, Denmark
Braaten, Tonje (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Colorado-Yohar, Sandra M. (författare)
CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Crous-Bou, Marta (författare)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health. Boston, MA, United States
Dahm, Christina C. (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Fortner, Renée T (författare)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Gram, Inger T. (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
Harlid, Sophia, 1978- (författare)
Umeå universitet,Obstetrik och gynekologi
Heath, Alicia K. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Idahl, Annika, 1965- (författare)
Umeå universitet,Obstetrik och gynekologi
Kvaskoff, Marina (författare)
UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
Nøst, Therese H. (författare)
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
Overvad, Kim (författare)
Department of Public Health, Aarhus University, Aarhus, Denmark
Palli, Domenico (författare)
Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
Perez-Cornago, Aurora (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Sacerdote, Carlotta (författare)
Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
Sánchez, Maria-Jose (författare)
Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Schulze, Matthias B. (författare)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Severi, Gianluca (författare)
UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy
Simeon, Vittorio (författare)
Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, University of Naples "L. Vanvitelli", Naples, Italy
Tagliabue, Giovanna (författare)
Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian 1, Milan, Italy
Tjønneland, Anne (författare)
Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Truong, Thérèse (författare)
UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research, Ragusa, Italy
Johansson, Mattias (författare)
Section of Genetics, International Agency for Research on Cancer, Lyon, France
Weiderpass, Elisabete (författare)
Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France
Murphy, Neil (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Gunter, Marc J. (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
Lacey, Ben (författare)
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Allen, Naomi E. (författare)
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Dossus, Laure (författare)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
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 (creator_code:org_t)
American Association for Cancer Research, 2022
2022
Engelska.
Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 31:9, s. 1839-1848
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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