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Sökning: onr:"swepub:oai:lup.lub.lu.se:4d170e28-b4e4-4126-8b29-15df64a65d36" > A body shape index ...

A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort

Christakoudi, Sofia (författare)
Imperial College London,King's College London
Tsilidis, Konstantinos K. (författare)
University of Ioannina,Imperial College London
Dossus, Laure (författare)
International Agency for Research on Cancer, World Health Organization
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Rinaldi, Sabina (författare)
International Agency for Research on Cancer, World Health Organization
Weiderpass, Elisabete (författare)
International Agency for Research on Cancer, World Health Organization
Antoniussen, Christian S. (författare)
Aarhus University
Dahm, Christina C. (författare)
Aarhus University
Tjønneland, Anne (författare)
University of Copenhagen,Danish Cancer Society
Mellemkjær, Lene (författare)
Danish Cancer Society
Katzke, Verena (författare)
German Cancer Research Centre
Kaaks, Rudolf (författare)
German Cancer Research Centre
Schulze, Matthias B. (författare)
University of Potsdam,German Institute of Human Nutrition
Masala, Giovanna (författare)
Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
Grioni, Sara (författare)
Istituto Nazionale dei Tumori
Panico, Salvatore (författare)
University of Naples Federico II
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research
Sacerdote, Carlotta (författare)
Citta' della Salute e della Scienza Hospital-University of Turin
May, Anne M. (författare)
University Medical Center Utrecht
Monninkhof, Evelyn M. (författare)
University Medical Center Utrecht
Quirós, J. Ramón (författare)
Bonet, Catalina (författare)
Bellvitge Biomedical Research Institute,Catalan Institute of Oncology
Sánchez, Maria Jose (författare)
CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
Amiano, Pilar (författare)
Biodonostia Health Research Institute,Ministry of Health of the Basque Government,CIBER Epidemiology and Public Health (CIBERESP)
Chirlaque, María Dolores (författare)
University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
Guevara, Marcela (författare)
CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)
Rosendahl, Ann H. (författare)
Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröstcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breastcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
Stocks, Tanja (författare)
Lund University,Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Register-based epidemiology,Department of Translational Medicine,Faculty of Medicine
Perez-Cornago, Aurora (författare)
University of Oxford
Tin Tin, Sandar (författare)
University of Oxford
Heath, Alicia K. (författare)
Imperial College London
Aglago, Elom K. (författare)
Imperial College London
Peruchet-Noray, Laia (författare)
University of Barcelona,International Agency for Research on Cancer, World Health Organization
Freisling, Heinz (författare)
International Agency for Research on Cancer, World Health Organization
Riboli, Elio (författare)
Imperial College London
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 (creator_code:org_t)
2023
2023
Engelska.
Ingår i: BMC Cancer. - 1471-2407. ; 23:1
Relaterad länk:
http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI). Methods: We evaluated body shape with the allometric “a body shape index” (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961–1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951–1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822–0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835–0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049–1.098), for post-menopausal women (HR = 1.117; 1.085–1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076–1.132), and for ER + PR + subtypes (HR = 1.122; 1.080–1.165; n = 3101), but not for PR- subtypes. Conclusions: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

ABSI
Body shape
Breast cancer
Hip size
Obesity
Waist size

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art (ämneskategori)
ref (ämneskategori)

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