Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

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Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition

Breeur, Marie (författare): International Agency for Research on Cancer, World Health Organization

Ferrari, Pietro (författare): International Agency for Research on Cancer, World Health Organization

Dossus, Laure (författare): International Agency for Research on Cancer, World Health Organization

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Jenab, Mazda (författare): International Agency for Research on Cancer, World Health Organization

Johansson, Mattias (författare): International Agency for Research on Cancer, World Health Organization

Rinaldi, Sabina (författare): International Agency for Research on Cancer, World Health Organization

Travis, Ruth C. (författare): University of Oxford

His, Mathilde (författare): International Agency for Research on Cancer, World Health Organization

Key, Tim J. (författare): University of Oxford

Schmidt, Julie A. (författare): University of Oxford,Aarhus University Hospital

Overvad, Kim (författare): Aarhus University

Tjønneland, Anne (författare): Danish Cancer Society

Kyrø, Cecilie (författare): Danish Cancer Society

Rothwell, Joseph A. (författare): Versailles Saint-Quentin-en-Yvelines University

Laouali, Nasser (författare): Versailles Saint-Quentin-en-Yvelines University

Severi, Gianluca (författare): Versailles Saint-Quentin-en-Yvelines University

Kaaks, Rudolf (författare): German Cancer Research Centre

Katzke, Verena (författare): German Cancer Research Centre

Schulze, Matthias B. (författare): German Institute of Human Nutrition

Eichelmann, Fabian (författare): German Center for Diabetes Research,German Institute of Human Nutrition

Palli, Domenico (författare): Institute for Cancer Research, Prevention and Clinical Network (ISPRO)

Grioni, Sara (författare): Istituto Nazionale dei Tumori

Panico, Salvatore (författare): University of Naples Federico II

Tumino, Rosario (författare)

Sacerdote, Carlotta (författare): Citta' della Salute e della Scienza Hospital-University of Turin

Bueno-de-Mesquita, Bas (författare): National Institute for Public Health and the Environment (RIVM)

Olsen, Karina Standahl (författare): UiT The Arctic University of Norway, Tromsø

Sandanger, Torkjel Manning (författare): UiT The Arctic University of Norway, Tromsø

Nøst, Therese Haugdahl (författare): UiT The Arctic University of Norway, Tromsø

Quirós, J. Ramón (författare): Public Health Directorate

Bonet, Catalina (författare): Bellvitge University Hospital-IDIBELL

Barranco, Miguel Rodríguez (författare): Andalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)

Chirlaque, María-Dolores (författare): University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)

Ardanaz, Eva (författare): CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA)

Sandsveden, Malte (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments

Manjer, Jonas (författare): Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital

Vidman, Linda (författare): Umeå University,Umeå universitet,Onkologi

Rentoft, Matilda (författare): Umeå University,Umeå universitet,Onkologi

Muller, David (författare): Imperial College London

Tsilidis, Kostas (författare): Imperial College London

Heath, Alicia K. (författare): Imperial College London

Keun, Hector (författare): Imperial College London

Adamski, Jerzy (författare): University of Ljubljana,Helmholtz Zentrum München,National University of Singapore

Keski-Rahkonen, Pekka (författare): International Agency for Research on Cancer, World Health Organization

Scalbert, Augustin (författare): International Agency for Research on Cancer, World Health Organization

Gunter, Marc J. (författare): International Agency for Research on Cancer, World Health Organization

Viallon, Vivian (författare): International Agency for Research on Cancer, World Health Organization

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(creator_code:org_t)

2022-10-19
2022
Engelska.
Ingår i: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 20:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); http://dx.doi.org/10... (free); https://urn.kb.se/re...; https://doi.org/10.1...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Breast
Cancer
Colorectal
Endometrial
EPIC
Kidney
Lasso
Liver
Metabolomics
Prostate
Breast
Cancer
Colorectal
Endometrial
EPIC
Kidney
Lasso
Liver
Metabolomics
Prostate

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Av författaren/redakt...: Breeur, Marie; Ferrari, Pietro; Dossus, Laure; Jenab, Mazda; Johansson, Matti ...; Rinaldi, Sabina; visa fler...; Travis, Ruth C.; His, Mathilde; Key, Tim J.; Schmidt, Julie A ...; Overvad, Kim; Tjønneland, Anne; Kyrø, Cecilie; Rothwell, Joseph ...; Laouali, Nasser; Severi, Gianluca; Kaaks, Rudolf; Katzke, Verena; Schulze, Matthia ...; Eichelmann, Fabi ...; Palli, Domenico; Grioni, Sara; Panico, Salvator ...; Tumino, Rosario; Sacerdote, Carlo ...; Bueno-de-Mesquit ...; Olsen, Karina St ...; Sandanger, Torkj ...; Nøst, Therese Ha ...; Quirós, J. Ramón; Bonet, Catalina; Barranco, Miguel ...; Chirlaque, María ...; Ardanaz, Eva; Sandsveden, Malt ...; Manjer, Jonas; Vidman, Linda; Rentoft, Matilda; Muller, David; Tsilidis, Kostas; Heath, Alicia K.; Keun, Hector; Adamski, Jerzy; Keski-Rahkonen, ...; Scalbert, August ...; Gunter, Marc J.; Viallon, Vivian; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

Artiklar i publikationen: BMC Medicine

Av lärosätet: Umeå universitet; Lunds universitet

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