Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Tyck till om SwePub Sök här!

Sökning: onr:"swepub:oai:gup.ub.gu.se/316538" > Multiomics analysis...

1 av 1
Föregående post
Nästa post
Till träfflistan

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset

Saevarsdottir, S. (författare): Karolinska Institutet,deCODE Genet Amgen, Iceland; Karolinska Inst, Sweden; Univ Iceland, Iceland; Natl Univ Hosp Iceland, Iceland,University of Iceland

Stefansdottir, L. (författare)

Sulem, P. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

visa fler...

Thorleifsson, G. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Ferkingstad, E. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Rutsdottir, G. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Glintborg, B. (författare): Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis,Ctr Head & Orthopaed, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.

Westerlind, H. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Grondal, G. (författare): Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medicine, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland; Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Med, Landspitali, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.,Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.

Loft, I. C. (författare): Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark,Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark.

Sorensen, S. B. (författare): Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark,Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Oslo, Dept Med Genet, Oslo, Norway.,Univ Hosp Southern Denmark, IRS Ctr Sonderjylland, Mol Diagnost & Clin Res Unit, Aabenraa, Denmark.,Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, Copenhagen, Denmark.

Lie, B. A. (författare): Karolinska Institutet,Univ Oslo, Norway; Oslo Univ Hosp, Norway

Brink, Mikael (författare): Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.

Ärlestig, Lisbeth, 1954- (författare): Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.

Arnthorsson, A. O. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.,Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.

Baecklund, Eva, 1956- (författare): Uppsala universitet,Reumatologi,Uppsala Univ, Sweden

Banasik, K. (författare): Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Fac Hlth & Med Sci, Copenhagen, Denmark.

Bank, S. (författare)

Björkman, Lena, 1965 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.

Ellingsen, T. (författare): OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark,Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Odense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.;Univ Southern Denmark, Odense, Denmark.

Erikstrup, C. (författare): Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Clin Immunol, Aarhus, Denmark.

Frei, O. (författare): NORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Center for Bioinformatics, Department of Informatics, University of Oslo, Oslo, Norway,Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.;Univ Oslo, Ctr Bioinformat, Dept Informat, Oslo, Norway.

Gjertsson, Inger, 1962 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Department of Rheumatology and Inflammation Research, Gothenburg University, Gothenburg, Sweden,Gothenburg Univ, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.

Gudbjartsson, D. F. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.

Gudjonsson, S. A. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Halldorsson, G. H. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.

Hendricks, O. (författare): Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark; Department of Regional Health Research, University of Southern Denmark, Odense, Denmark,Univ Hosp Southern Denmark, Danish Hosp Rheumat Dis, Sonderborg, Denmark.;Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.

Hillert, J. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Hogdall, E. (författare): Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Herlev Hosp, Dept Pathol, Copenhagen, Denmark.

Jacobsen, S. (författare): Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Copenhagen Lupus and Vasculitis Clinic, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark,Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.;Rigshosp, Ctr Rheumatol & Spine Dis, Copenhagen Lupus & Vasculitis Clin, Copenhagen, Denmark.

Jensen, D. V. (författare): Department of Rheumatology, Center for Rheumatology and Spine Diseases, Gentofte and Herlev Hospital, Rønne, Denmark,Gentofte & Herlev Hosp, Ctr Rheumatol & Spine Dis, Dept Rheumatol, Ronne, Denmark.

Jonsson, H. (författare): Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medicine, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Med, Landspitali, Reykjavik, Iceland.

Kastbom, Alf (författare): Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland

Kockum, I. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Kristensen, S. (författare): Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark,Aalborg Univ Hosp, Dept Rheumatol, Aalborg, Denmark.;Aalborg Univ, Dept Clin Med, Aalborg, Denmark.,University of Iceland

Kristjansdottir, H. (författare): Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.

Larsen, M. H. (författare): Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Rheumatology Research Unit, Odense University Hospital and University of Southern Denmark, Odense, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Odense Univ Hosp, Rheumatol Res Unit, Odense, Denmark.;Univ Southern Denmark, Odense, Denmark.

Linauskas, A. (författare): Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Rheumatology, North Denmark Regional Hospital, Hjørring, Denmark,Aalborg Univ, Dept Clin Med, Aalborg, Denmark.;North Denmark Reg Hosp, Dept Rheumatol, Hjorring, Denmark.

Hauge, E. M. (författare): Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark,Aarhus Univ Hosp, Dept Rheumatol, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.

Loft, A. G. (författare)

Ludviksson, B. R. (författare): Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Immunol, Landspitali, Reykjavik, Iceland.

Lund, S. H. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,Section of Rheumatology, Oslo University Hospital, Oslo, Norway; Oslo New University College, Oslo, Norway,deCODE Genet Amgen, Reykjavik, Iceland.,Oslo Univ Hosp, Sect Rheumatol, Oslo, Norway.;Oslo New Univ Coll, Oslo, Norway.

Markusson, T. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.

Masson, G. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Melsted, P. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Sch Engn & Nat Sci, Reykjavik, Iceland.

Moore, K. H. S. (författare): Center for Rheumatology Research, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,Natl Univ Hosp Iceland, Ctr Rheumatol Res, Landspitali, Reykjavik, Iceland.,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.

Munk, H. (författare)

Nielsen, K. R. (författare): Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark,Aalborg Univ Hosp, Dept Clin Immunol, Aalborg, Denmark.

Norddahl, G. L. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Oddsson, A. (författare)

Olafsdottir, T. A. (författare)

Olason, P. I. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.

Olsson, T. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Ostrowski, S. R. (författare): Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,DeCODE Genetics/Amgen, Reykjavik, Iceland,Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.;Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.,deCODE Genet Amgen, Reykjavik, Iceland.

Horslev-Petersen, K. (författare): Danish Hospital for Rheumatic Diseases, University Hospital of Southern Denmark, Sønderborg, Denmark,Univ Hosp Southern Denmark, Danish Hosp Rheumat Dis, Sonderborg, Denmark.

Rognvaldsson, S. (författare)

Sanner, H. (författare)

Silberberg, G. N. (författare): Division of Rheumatology, Department of Medicine, Solna Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med, Div Rheumatol, Stockholm, Sweden.

Stefansson, H. (författare)

Sorensen, E. (författare): Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.

Sorensen, I. J. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Immunology, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.;Natl Univ Hosp Iceland, Dept Immunol, Landspitali, Reykjavik, Iceland.

Turesson, C. (författare): Lund University,Lunds universitet,Reumatologi,Forskargrupper vid Lunds universitet,Rheumatology,Lund University Research Groups

Bergman, T. (författare): Division of Clinical Epidemiology, Department of Medicine, Solna Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Med, Div Clin Epidemiol, Stockholm, Sweden.

Alfredsson, L. (författare): Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden.

Kvien, T. K. (författare): University of Oslo, Oslo, Norway; Diakonhjemmet Hospital, Oslo, Norway,Univ Oslo, Oslo, Norway.;Diakonhjemmet Hosp, Oslo, Norway.

Brunak, S. (författare)

Steinsson, K. (författare)

Andersen, V. (författare): Molecular Diagnostics and Clinical Research Unit, IRS-Center Sonderjylland, University Hospital of Southern Denmark, Aabenraa, Denmark; OPEN Explorative Network, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark,Univ Hosp Southern Denmark, IRS Ctr Sonderjylland, Mol Diagnost & Clin Res Unit, Aabenraa, Denmark.;Univ Southern Denmark, Open Explorat Network, Odense, Denmark.;Univ Southern Denmark, Inst Mol Med, Odense, Denmark.

Andreassen, O. A. (författare)

Rantapää-Dahlqvist, Solbritt (författare): Umeå universitet,Reumatologi,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.

Hetland, M. L. (författare): Danish Rheumatologic Biobank and Copenhagen Center for Arthritis Research (COPECARE), Centre for Rheumatology and Spine Diseases, Copenhagen University Hospital Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark,Copenhagen Univ Hosp, Rigshosp, Copenhagen Ctr Arthrit Res COPECARE, Ctr Rheumatol & Spine Dis,Ctr Head & Orthopaed, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.

Klareskog, L. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Askling, J. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Padyukov, L. (författare): Karolinska Institutet,Karolinska Inst, Sweden

Pedersen, O. B. (författare): Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark,Zealand Univ Hosp, Dept Clin Immunol, Koge, Denmark.

Thorsteinsdottir, U. (författare): DeCODE Genetics/Amgen, Reykjavik, Iceland; Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland,deCODE Genet Amgen, Reykjavik, Iceland.;Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.

Jonsdottir, I. (författare)

Stefansson, K. (författare)

visa färre...

(creator_code:org_t)

2022-04-25
2022
Engelska.
Ingår i: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 81:8

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://uu.diva-port... (primary) (Raw object); https://liu.diva-por... (primary) (Raw object); http://dx.doi.org/10... (free); https://gup.ub.gu.se...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; https://urn.kb.se/re...; https://lup.lub.lu.s...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Objectives To find causal genes for rheumatoid arthritis (RA) and its seropositive (RF and/or ACPA positive) and seronegative subsets. Methods We performed a genome-wide association study (GWAS) of 31 313 RA cases (68% seropositive) and similar to 1 million controls from Northwestern Europe. We searched for causal genes outside the HLA-locus through effect on coding, mRNA expression in several tissues and/or levels of plasma proteins (SomaScan) and did network analysis (Qiagen). Results We found 25 sequence variants for RA overall, 33 for seropositive and 2 for seronegative RA, altogether 37 sequence variants at 34 non-HLA loci, of which 15 are novel. Genomic, transcriptomic and proteomic analysis of these yielded 25 causal genes in seropositive RA and additional two overall. Most encode proteins in the network of interferon-alpha/beta and IL-12/23 that signal through the JAK/STAT-pathway. Highlighting those with largest effect on seropositive RA, a rare missense variant in STAT4 (rs140675301-A) that is independent of reported non-coding STAT4-variants, increases the risk of seropositive RA 2.27-fold (p=2.1x10(-9)), more than the rs2476601-A missense variant in PTPN22 (OR=1.59, p=1.3x10(-160)). STAT4 rs140675301-A replaces hydrophilic glutamic acid with hydrophobic valine (Glu128Val) in a conserved, surface-exposed loop. A stop-mutation (rs76428106-C) in FLT3 increases seropositive RA risk (OR=1.35, p=6.6x10(-11)). Independent missense variants in TYK2 (rs34536443-C, rs12720356-C, rs35018800-A, latter two novel) associate with decreased risk of seropositive RA (ORs=0.63-0.87, p=10(-9)-10(-27)) and decreased plasma levels of interferon-alpha/beta receptor 1 that signals through TYK2/JAK1/STAT4. Conclusion Sequence variants pointing to causal genes in the JAK/STAT pathway have largest effect on seropositive RA, while associations with seronegative RA remain scarce.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

rheumatoid arthritis
autoantibodies
polymorphism
genetic
DNA-binding
stat4
classification
association
inhibitor
criteria
cells
fms
Rheumatology
autoantibodies

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Annals of the Rheumatic Diseases (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Av författaren/redakt...: Saevarsdottir, S ...; Stefansdottir, L ...; Sulem, P.; Thorleifsson, G.; Ferkingstad, E.; Rutsdottir, G.; visa fler...; Glintborg, B.; Westerlind, H.; Grondal, G.; Loft, I. C.; Sorensen, S. B.; Lie, B. A.; Brink, Mikael; Ärlestig, Lisbet ...; Arnthorsson, A. ...; Baecklund, Eva, ...; Banasik, K.; Bank, S.; Björkman, Lena, ...; Ellingsen, T.; Erikstrup, C.; Frei, O.; Gjertsson, Inger ...; Gudbjartsson, D. ...; Gudjonsson, S. A ...; Halldorsson, G. ...; Hendricks, O.; Hillert, J.; Hogdall, E.; Jacobsen, S.; Jensen, D. V.; Jonsson, H.; Kastbom, Alf; Kockum, I.; Kristensen, S.; Kristjansdottir, ...; Larsen, M. H.; Linauskas, A.; Hauge, E. M.; Loft, A. G.; Ludviksson, B. R ...; Lund, S. H.; Markusson, T.; Masson, G.; Melsted, P.; Moore, K. H. S.; Munk, H.; Nielsen, K. R.; Norddahl, G. L.; Oddsson, A.; Olafsdottir, T. ...; Olason, P. I.; Olsson, T.; Ostrowski, S. R.; Horslev-Petersen ...; Rognvaldsson, S.; Sanner, H.; Silberberg, G. N ...; Stefansson, H.; Sorensen, E.; Sorensen, I. J.; Turesson, C.; Bergman, T.; Alfredsson, L.; Kvien, T. K.; Brunak, S.; Steinsson, K.; Andersen, V.; Andreassen, O. A ...; Rantapää-Dahlqvi ...; Hetland, M. L.; Klareskog, L.; Askling, J.; Padyukov, L.; Pedersen, O. B.; Thorsteinsdottir ...; Jonsdottir, I.; Stefansson, K.; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Reumatologi och ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

NATURVETENSKAP: NATURVETENSKAP; och Biologi; och Biokemi och mole ...

Artiklar i publikationen: Annals of the Rh ...

Av lärosätet: Göteborgs universitet; Umeå universitet; Uppsala universitet; Karolinska Institutet; Linköpings universitet; Lunds universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se