A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention

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A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention

Lankinen, Maria (författare): Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

Schwab, Ursula (författare): Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Inst Clin Med, Internal Med, SF-70210 Kuopio, Finland.

Kolehmainen, Marjukka (författare): Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.

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Paananen, Jussi (författare): Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland,Univ Eastern Finland, Inst Biomed, Kuopio, Finland.

Nygren, Heli (författare): VTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo, Finland.

Seppänen-Laakso, Tuulikki (författare): VTT Technical Research Centre of Finland, Espoo, Finland,VTT Tech Res Ctr Finland, Espoo, Finland.

Poutanen, Kaisa (författare): Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;VTT Tech Res Ctr Finland, Espoo, Finland.

Hyötyläinen, Tuulia, 1971- (författare): Örebro universitet,Institutionen för naturvetenskap och teknik,VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark,VTT Tech Res Ctr Finland, Espoo, Finland.;Steno Diabet Ctr, DK-2820 Gentofte, Denmark.

Risérus, Ulf (författare): Uppsala universitet,Klinisk nutrition och metabolism

Savolainen, Markku J. (författare): Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland,Univ Oulu, Res Ctr Internal Med & Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Dept Internal Med, Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.

Hukkanen, Janne (författare): Research Center for Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Internal Medicine, Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland,Univ Oulu, Res Ctr Internal Med & Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Dept Internal Med, Oulu, Finland.;Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.;Univ Oulu, Oulu, Finland.

Brader, Lea (författare): Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark.

Marklund, Matti (författare): Uppsala universitet,Klinisk nutrition och metabolism

Rosqvist, Fredrik (författare): Uppsala universitet,Klinisk nutrition och metabolism

Hermansen, Kjeld (författare): Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8000 Aarhus, Denmark.

Cloetens, Lieselotte (författare): Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.

Önning, Gunilla (författare): Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.

Thorsdottir, Inga (författare): Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, , Reykjavik, Iceland; Landspitali – University Hospital, Reykjavik, Iceland,Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland.

Gunnarsdottir, Ingibjorg (författare): Unit for Nutrition Research, Faculty of Food Science and Nutrition, School of Health Sciences, University of Iceland, , Reykjavik, Iceland; Landspitali – University Hospital, Reykjavik, Iceland,Univ Iceland, Sch Hlth Sci, Fac Food Sci & Nutr, Unit Nutr Res, Reykjavik, Iceland.;Landspitali Univ Hosp, Reykjavik, Iceland.

Åkesson, Björn (författare): Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Lund Univ, Biomed Nutr Pure & Appl Biochem, Lund, Sweden.;Skane Univ Hosp, Dept Clin Nutr, Lund, Sweden.

Dragsted, Lars Ove (författare): Faculty of Science, Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark,Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.

Uusitupa, Matti (författare): Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland;,Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.;Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland.

Orešič, Matej, 1967- (författare): VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark,VTT Tech Res Ctr Finland, Espoo, Finland.;Steno Diabet Ctr, DK-2820 Gentofte, Denmark.

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Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland (creator_code:org_t)

New York, USA : Oxford University Press, 2016
2016
Engelska.
Ingår i: Journal of Nutrition. - New York, USA : Oxford University Press. - 0022-3166 .- 1541-6100. ; 146:4, s. 662-672

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BACKGROUND: A healthy Nordic diet is associated with improvements in cardiometabolic risk factors, but the effect on lipidomic profile is not known.OBJECTIVE: The aim was to investigate how a healthy Nordic diet affects the fasting plasma lipidomic profile in subjects with metabolic syndrome.METHODS: Men and women (n = 200) with features of metabolic syndrome [mean age: 55 y; body mass index (in kg/m(2)): 31.6] were randomly assigned to either a healthy Nordic (n = 104) or a control (n = 96) diet for 18 or 24 wk at 6 centers. Of the participants, 156 completed the study with plasma lipidomic measurements. The healthy Nordic diet consisted of whole grains, fruits, vegetables, berries, vegetable oils and margarines, fish, low-fat milk products, and low-fat meat. An average Nordic diet served as the control diet and included low-fiber cereal products, dairy fat-based spreads, regular-fat milk products, and a limited amount of fruits, vegetables, and berries. Lipidomic profiles were measured at baseline, week 12, and the end of the intervention (18 or 24 wk) by using ultraperformance liquid chromatography mass spectrometry. The effects of the diets on the lipid variables were analyzed with linear mixed-effects models. Data from centers with 18- or 24-wk duration were also analyzed separately.RESULTS: Changes in 21 plasma lipids differed significantly between the groups at week 12 (false discovery rate P < 0.05), including increases in plasmalogens and decreases in ceramides in the healthy Nordic diet group compared with the control group. At the end of the study, changes in lipidomic profiles did not differ between the groups. However, when the intervention lasted 24 wk, changes in 8 plasma lipids that had been identified at 12 wk, including plasmalogens, were sustained. There were no differences in changes in plasma lipids between groups with an intervention of 18 wk. By the dietary biomarker score, adherence to diet did not explain the difference in the results related to the duration of the study.CONCLUSIONS: A healthy Nordic diet transiently modified the plasma lipidomic profile, specifically by increasing the concentrations of antioxidative plasmalogens and decreasing insulin resistance-inducing ceramides. This trial was registered at clinicaltrials.gov as NCT00992641.

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A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention

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