Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet)

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Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities : a randomized trial (Sysdimet)

Lankinen, Maria (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland

Kolehmainen, Marjukka (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Kuopio, Finland

Jääskeläinen, Tiina (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

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Paananen, Jussi (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

Joukamo, Laura (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finlands, Kuopio, Finland

Kangas, Antti J. (författare): Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland

Soininen, Pasi (författare): Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Poutanen, Kaisa (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland

Mykkänen, Hannu (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland

Gylling, Helena (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Division of Internal Medicine, Department of Medicine, University of Helsinki, Helsinki, Finland

Oresic, Matej, 1967- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,VTT Technical Research Centre of Finland, Espoo, Finland

Jauhiainen, Matti (författare): National Institute for Health and Welfare, Public Health Genomics Research Unit, Helsinki, Finland

Ala-Korpela, Mika (författare): Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland; NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Computational Medicine, School of Social and Community Medicine and the Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; Oulu University Hospital, Oulu, Finland

Uusitupa, Matti (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland

Schwab, Ursula (författare): Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland

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2014-02-28
2014
Engelska.
Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 9:2

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://journals.plo...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

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OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome.METHODS: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites.RESULTS: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable.CONCLUSIONS: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis.TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov NCT00573781.

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Av författaren/redakt...: Lankinen, Maria; Kolehmainen, Mar ...; Jääskeläinen, Ti ...; Paananen, Jussi; Joukamo, Laura; Kangas, Antti J.; visa fler...; Soininen, Pasi; Poutanen, Kaisa; Mykkänen, Hannu; Gylling, Helena; Oresic, Matej, 1 ...; Jauhiainen, Matt ...; Ala-Korpela, Mik ...; Uusitupa, Matti; Schwab, Ursula; visa färre...

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Av lärosätet: Örebro universitet

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Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities : a randomized trial (Sysdimet)

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