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Robust genome-wide ...
Robust genome-wide ancestry inference for heterogeneous datasets : illustrated using the 1,000 genome project with 3D facial images
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- Li, Jiarui (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.
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- Zarzar, Tomas Gonzalez (author)
- Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
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- White, Julie D. (author)
- Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
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- Indencleef, Karlijne (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Expt Otorhinolaryngol, Leuven, Belgium.
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- Hoskens, Hanne (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.
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- Matthews, Harry (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
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- Nauwelaers, Nele (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.
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- Zaidi, Arslan (author)
- Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
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- Eller, Ryan J. (author)
- Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.
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- Herrick, Noah (author)
- Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.
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- Günther, Torsten (author)
- Uppsala universitet,Människans evolution
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- Svensson, Emma, 1979- (author)
- Uppsala universitet,Människans evolution
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- Jakobsson, Mattias (author)
- Uppsala universitet,Människans evolution
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- Walsh, Susan (author)
- Indiana Univ Purdue Univ Indianapolis, Dept Biol, Indianapolis, IN USA.
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- Van Steen, Kristel (author)
- Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Univ Liege, Med Genom Res Unit, GIGA R, Liege, Belgium.;Walloon Excellence Life Sci & Biotechnol WELBIO, Liege, Belgium.
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- Shriver, Mark D. (author)
- Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA.
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- Claes, Peter (author)
- Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium.;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium.;Katholieke Univ Leuven, Dept Human Genet, Leuven, Belgium.;Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
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Univ Hosp Leuven, MIRC, Med Imaging Res Ctr, Leuven, Belgium;Katholieke Univ Leuven, Dept Elect Engn, ESAT PSI, Leuven, Belgium. Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA. (creator_code:org_t)
- 2020-07-16
- 2020
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Abstract
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- Estimates of individual-level genomic ancestry are routinely used in human genetics, and related fields. The analysis of population structure and genomic ancestry can yield insights in terms of modern and ancient populations, allowing us to address questions regarding admixture, and the numbers and identities of the parental source populations. Unrecognized population structure is also an important confounder to correct for in genome-wide association studies. However, it remains challenging to work with heterogeneous datasets from multiple studies collected by different laboratories with diverse genotyping and imputation protocols. This work presents a new approach and an accompanying open-source toolbox that facilitates a robust integrative analysis for population structure and genomic ancestry estimates for heterogeneous datasets. We show robustness against individual outliers and different protocols for the projection of new samples into a reference ancestry space, and the ability to reveal and adjust for population structure in a simulated case-control admixed population. Given that visually evident and easily recognizable patterns of human facial characteristics co-vary with genomic ancestry, and based on the integration of three different sources of genome data, we generate average 3D faces to illustrate genomic ancestry variations within the 1,000 Genome project and for eight ancient-DNA profiles, respectively.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Jiarui
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Zarzar, Tomas Go ...
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White, Julie D.
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Indencleef, Karl ...
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Hoskens, Hanne
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Matthews, Harry
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show more...
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Nauwelaers, Nele
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Zaidi, Arslan
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Eller, Ryan J.
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Herrick, Noah
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Günther, Torsten
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Svensson, Emma, ...
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Jakobsson, Matti ...
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Walsh, Susan
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Van Steen, Krist ...
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Shriver, Mark D.
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Claes, Peter
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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Scientific Repor ...
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Uppsala University