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Risk of complicatio...
Risk of complications in patients with conservatively managed ovarian tumours (IOTA5) : a 2-year interim analysis of a multicentre, prospective, cohort study
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- Froyman, Wouter (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Landolfo, Chiara (författare)
- Catholic University of Leuven,Queen Charlotte's and Chelsea Hospital
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- De Cock, Bavo (författare)
- Catholic University of Leuven
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visa fler...
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- Wynants, Laure (författare)
- Catholic University of Leuven
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- Sladkevicius, Povilas (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Testa, Antonia Carla (författare)
- Catholic University of the Sacred Heart, Rome,Policlinico Universitario Agostino Gemelli
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- Van Holsbeke, Caroline (författare)
- Hospital Oost-Limburg
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- Domali, Ekaterini (författare)
- Alexandra Hospital, Athens,National and Kapodistrian University of Athens
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- Fruscio, Robert (författare)
- University of Milano-Bicocca,San Gerardo Hospital
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- Epstein, Elisabeth (författare)
- Karolinska Institutet,Stockholm South General Hospital
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- dos Santos Bernardo, Maria José (författare)
- Centro Hospitalar Universitário de Lisboa Central
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- Franchi, Dorella (författare)
- European Institute of Oncology
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- Kudla, Marek Jerzy (författare)
- Medical University of Silesia
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- Chiappa, Valentina (författare)
- Istituto Nazionale dei Tumori
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- Alcazar, Juan Luis (författare)
- University Clinic of Navarra
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- Leone, Francesco Paolo Giuseppe (författare)
- University of Milan,Luigi Sacco University Hospital
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- Buonomo, Francesca (författare)
- Burlo Garofolo Pediatric Institute
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- Hochberg, Lauri (författare)
- University of South Florida
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- Coccia, Maria Elisabetta (författare)
- University of Florence
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- Guerriero, Stefano (författare)
- Azienda Ospedaliero Universitaria-Policlinico Duilio Casula,University of Cagliari
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- Deo, Nandita (författare)
- Whipps Cross University Hospital
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- Jokubkiene, Ligita (författare)
- Lund University,Lunds universitet,Urogynekologi och reproduktionsfarmakologi,Forskargrupper vid Lunds universitet,Urogynaecology and Reproductive Pharmacology,Lund University Research Groups,Skåne University Hospital
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- Kaijser, Jeroen (författare)
- Ikazia Hospital
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- Coosemans, An (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Vergote, Ignace (författare)
- University Hospitals Leuven,Catholic University of Leuven
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- Verbakel, Jan Yvan (författare)
- University of Oxford,Catholic University of Leuven
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- Bourne, Tom (författare)
- Queen Charlotte's and Chelsea Hospital,Catholic University of Leuven,University Hospitals Leuven
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- Van Calster, Ben (författare)
- Catholic University of Leuven,Leiden University Medical Centre
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- Valentin, Lil (författare)
- Lund University,Lunds universitet,Obstetrisk, gynekologisk och prenatal ultraljudsdiagnostik,Forskargrupper vid Lunds universitet,Obstetric, Gynaecological and Prenatal Ultrasound Research,Lund University Research Groups,Skåne University Hospital
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- Timmerman, Dirk (författare)
- Catholic University of Leuven,University Hospitals Leuven
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(creator_code:org_t)
- 2019
- 2019
- Engelska 11 s.
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Ingår i: The Lancet Oncology. - 1470-2045 .- 1474-5488. ; 20:3, s. 448-458
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Ovarian tumours are usually surgically removed because of the presumed risk of complications. Few large prospective studies on long-term follow-up of adnexal masses exist. We aimed to estimate the cumulative incidence of cyst complications and malignancy during the first 2 years of follow-up after adnexal masses have been classified as benign by use of ultrasonography. Methods: In the international, prospective, cohort International Ovarian Tumor Analysis Phase 5 (IOTA5) study, patients aged 18 years or older with at least one adnexal mass who had been selected for surgery or conservative management after ultrasound assessment were recruited consecutively from 36 cancer and non-cancer centres in 14 countries. Follow-up of patients managed conservatively is ongoing at present. In this 2-year interim analysis, we analysed patients who were selected for conservative management of an adnexal mass judged to be benign on ultrasound on the basis of subjective assessment of ultrasound images. Conservative management included ultrasound and clinical follow-up at intervals of 3 months and 6 months, and then every 12 months thereafter. The main outcomes of this 2-year interim analysis were cumulative incidence of spontaneous resolution of the mass, torsion or cyst rupture, or borderline or invasive malignancy confirmed surgically in patients with a newly diagnosed adnexal mass. IOTA5 is registered with ClinicalTrials.gov, number NCT01698632, and the central Ethics Committee and the Belgian Federal Agency for Medicines and Health Products, number S51375/B32220095331, and is ongoing. Findings: Between Jan 1, 2012, and March 1, 2015, 8519 patients were recruited to IOTA5. 3144 (37%) patients selected for conservative management were eligible for inclusion in our analysis, of whom 221 (7%) had no follow-up data and 336 (11%) were operated on before a planned follow-up scan was done. Of 2587 (82%) patients with follow-up data, 668 (26%) had a mass that was already in follow-up at recruitment, and 1919 (74%) presented with a new mass at recruitment (ie, not already in follow-up in the centre before recruitment). Median follow-up of patients with new masses was 27 months (IQR 14–38). The cumulative incidence of spontaneous resolution within 2 years of follow-up among those with a new mass at recruitment (n=1919) was 20·2% (95% CI 18·4–22·1), and of finding invasive malignancy at surgery was 0·4% (95% CI 0·1–0·6), 0·3% (<0·1–0·5) for a borderline tumour, 0·4% (0·1–0·7) for torsion, and 0·2% (<0·1–0·4) for cyst rupture. Interpretation: Our results suggest that the risk of malignancy and acute complications is low if adnexal masses with benign ultrasound morphology are managed conservatively, which could be of value when counselling patients, and supports conservative management of adnexal masses classified as benign by use of ultrasound. Funding: Research Foundation Flanders, KU Leuven, Swedish Research Council.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
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Froyman, Wouter
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Landolfo, Chiara
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De Cock, Bavo
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Wynants, Laure
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Sladkevicius, Po ...
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Testa, Antonia C ...
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visa fler...
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Van Holsbeke, Ca ...
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Domali, Ekaterin ...
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Fruscio, Robert
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Epstein, Elisabe ...
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dos Santos Berna ...
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Franchi, Dorella
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Kudla, Marek Jer ...
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Chiappa, Valenti ...
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Alcazar, Juan Lu ...
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Leone, Francesco ...
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Buonomo, Frances ...
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Hochberg, Lauri
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Coccia, Maria El ...
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Guerriero, Stefa ...
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Deo, Nandita
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Jokubkiene, Ligi ...
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Kaijser, Jeroen
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Coosemans, An
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Vergote, Ignace
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Verbakel, Jan Yv ...
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Bourne, Tom
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Van Calster, Ben
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Valentin, Lil
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Timmerman, Dirk
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The Lancet Oncol ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet