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Birthweight is asso...
Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes
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- Hansen, Aleksander L. (author)
- Aarhus University Hospital,Steno Diabetes Center Copenhagen
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- Thomsen, Reimar W. (author)
- Aarhus University Hospital
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- Brøns, Charlotte (author)
- Steno Diabetes Center Copenhagen
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- Svane, Helene M.L. (author)
- Aarhus University Hospital
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- Jensen, Rasmus T. (author)
- University of Copenhagen
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- Andersen, Mette K. (author)
- University of Copenhagen
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- Hansen, Torben (author)
- University of Copenhagen
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- Nielsen, Jens S. (author)
- Odense University Hospital
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- Vestergaard, Peter (author)
- Aalborg University Hospital
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- Højlund, Kurt (author)
- Odense University Hospital
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- Jessen, Niels (author)
- Steno Diabetes Center Copenhagen
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- Olsen, Michael H. (author)
- Holbæk Hospital,University of Southern Denmark
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- Sørensen, Henrik T. (author)
- Aarhus University Hospital
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- Vaag, Allan A. (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Steno Diabetes Center Copenhagen
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(creator_code:org_t)
- 2023
- 2023
- English 13 s.
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In: Diabetologia. - 0012-186X. ; 66:9, s. 1680-1692
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Abstract
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- Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes but it is unknown whether low birthweight is associated with distinct clinical characteristics at disease onset. We examined whether a lower or higher birthweight in type 2 diabetes is associated with clinically relevant characteristics at disease onset. Methods: Midwife records were traced for 6866 individuals with type 2 diabetes in the Danish Centre for Strategic Research in Type 2 Diabetes (DD2) cohort. Using a cross-sectional design, we assessed age at diagnosis, anthropomorphic measures, comorbidities, medications, metabolic variables and family history of type 2 diabetes in individuals with the lowest 25% of birthweight (<3000 g) and highest 25% of birthweight (>3700 g), compared with a birthweight of 3000–3700 g as reference, using log-binomial and Poisson regression. Continuous relationships across the entire birthweight spectrum were assessed with linear and restricted cubic spline regression. Weighted polygenic scores (PS) for type 2 diabetes and birthweight were calculated to assess the impact of genetic predispositions. Results: Each 1000 g decrease in birthweight was associated with a 3.3 year (95% CI 2.9, 3.8) younger age of diabetes onset, 1.5 kg/m2 (95% CI 1.2, 1.7) lower BMI and 3.9 cm (95% CI 3.3, 4.5) smaller waist circumference. Compared with the reference birthweight, a birthweight of <3000 g was associated with more overall comorbidity (prevalence ratio [PR] for Charlson Comorbidity Index Score ≥3 was 1.36 [95% CI 1.07, 1.73]), having a systolic BP ≥155 mmHg (PR 1.26 [95% CI 0.99, 1.59]), lower prevalence of diabetes-associated neurological disease, less likelihood of family history of type 2 diabetes, use of three or more glucose-lowering drugs (PR 1.33 [95% CI 1.06, 1.65]) and use of three or more antihypertensive drugs (PR 1.09 [95% CI 0.99, 1.20]). Clinically defined low birthweight (<2500 g) yielded stronger associations. Most associations between birthweight and clinical characteristics appeared linear, and a higher birthweight was associated with characteristics mirroring lower birthweight in opposite directions. Results were robust to adjustments for PS representing weighted genetic predisposition for type 2 diabetes and birthweight. Conclusion/interpretation: Despite younger age at diagnosis, and fewer individuals with obesity and family history of type 2 diabetes, a birthweight <3000 g was associated with more comorbidities, including a higher systolic BP, as well as with greater use of glucose-lowering and antihypertensive medications, in individuals with recently diagnosed type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Age at diagnosis
- Birthweight
- Epidemiology
- Fetal programming
- Polygenic risk score
- Type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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Hansen, Aleksand ...
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Thomsen, Reimar ...
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Brøns, Charlotte
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Svane, Helene M. ...
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Jensen, Rasmus T ...
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Andersen, Mette ...
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Hansen, Torben
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Nielsen, Jens S.
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Vestergaard, Pet ...
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Højlund, Kurt
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Jessen, Niels
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Olsen, Michael H ...
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Sørensen, Henrik ...
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Vaag, Allan A.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Diabetologia
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Lund University