SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Wang JD)
 

Search: WFRF:(Wang JD) > Community assessmen...

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

Menden, MP (author)
Wang, D (author)
Mason, MJ (author)
show more...
Szalai, B (author)
Bulusu, KC (author)
Guan, YF (author)
Yu, T (author)
Kang, J (author)
Jeon, M (author)
Wolfinger, R (author)
Nguyen, T (author)
Zaslavskiy, M (author)
Jang, IS (author)
Ghazoui, Z (author)
Ahsen, ME (author)
Vogel, R (author)
Neto, EC (author)
Norman, T (author)
Tang, EKY (author)
Garnett, MJ (author)
Di Veroli, GY (author)
Fawell, S (author)
Stolovitzky, G (author)
Guinney, J (author)
Dry, JR (author)
Saez-Rodriguez, J (author)
Abante, J (author)
Abecassis, BS (author)
Aben, N (author)
Aghamirzaie, D (author)
Aittokallio, T (author)
Akhtari, FS (author)
Al-lazikani, B (author)
Alam, T (author)
Allam, A (author)
Allen, C (author)
de Almeida, MP (author)
Altarawy, D (author)
Alves, V (author)
Amadoz, A (author)
Anchang, B (author)
Antolin, AA (author)
Ash, JR (author)
Aznar, VR (author)
Ba-alawi, W (author)
Bagheri, M (author)
Bajic, V (author)
Ball, G (author)
Ballester, PJ (author)
Baptista, D (author)
Bare, C (author)
Bateson, M (author)
Bender, A (author)
Bertrand, D (author)
Wijayawardena, B (author)
Boroevich, KA (author)
Bosdriesz, E (author)
Bougouffa, S (author)
Bounova, G (author)
Brouwer, T (author)
Bryant, B (author)
Calaza, M (author)
Calderone, A (author)
Calza, S (author)
Capuzzi, S (author)
Carbonell-Caballero, J (author)
Carlin, D (author)
Carter, H (author)
Castagnoli, L (author)
Celebi, R (author)
Cesareni, G (author)
Chang, H (author)
Chen, GC (author)
Chen, HR (author)
Chen, HY (author)
Cheng, LJ (author)
Chernomoretz, A (author)
Chicco, D (author)
Cho, KH (author)
Cho, S (author)
Choi, D (author)
Choi, J (author)
Choi, K (author)
Choi, M (author)
De Cock, M (author)
Coker, E (author)
Cortes-Ciriano, I (author)
Cserzo, M (author)
Cubuk, C (author)
Curtis, C (author)
Van Daele, D (author)
Dang, CC (author)
Dijkstra, T (author)
Dopazo, J (author)
Draghici, S (author)
Drosou, A (author)
Dumontier, M (author)
Ehrhart, F (author)
Eid, FE (author)
ElHefnawi, M (author)
Elmarakeby, H (author)
van Engelen, B (author)
Engin, HB (author)
de Esch, I (author)
Evelo, C (author)
Falcao, AO (author)
Farag, S (author)
Fernandez-Lozano, C (author)
Fisch, K (author)
Flobak, A (author)
Fornari, C (author)
Foroushani, ABK (author)
Fotso, DC (author)
Fourches, D (author)
Friend, S (author)
Frigessi, A (author)
Gao, F (author)
Gao, XT (author)
Gerold, JM (author)
Gestraud, P (author)
Ghosh, S (author)
Gillberg, J (author)
Godoy-Lorite, A (author)
Godynyuk, L (author)
Godzik, A (author)
Goldenberg, A (author)
Gomez-Cabrero, D (author)
Karolinska Institutet
Gonen, M (author)
de Graaf, C (author)
Gray, H (author)
Grechkin, M (author)
Guimera, R (author)
Guney, E (author)
Haibe-Kains, B (author)
Han, Y (author)
Hase, T (author)
He, D (author)
He, LY (author)
Heath, LS (author)
Hellton, KH (author)
Helmer-Citterich, M (author)
Hidalgo, MR (author)
Hidru, D (author)
Hill, SM (author)
Hochreiter, S (author)
Hong, S (author)
Hovig, E (author)
Hsueh, YC (author)
Hu, ZY (author)
Huang, JK (author)
Huang, RS (author)
Hunyady, L (author)
Hwang, J (author)
Hwang, TH (author)
Hwang, W (author)
Hwang, Y (author)
Isayev, O (author)
Walk, OBD (author)
Jack, J (author)
Jahandideh, S (author)
Ji, JD (author)
Jo, Y (author)
Kamola, PJ (author)
Kanev, GK (author)
Karacosta, L (author)
Karimi, M (author)
Kaski, S (author)
Kazanov, M (author)
Khamis, AM (author)
Khan, SA (author)
Kiani, NA (author)
Karolinska Institutet
Kim, A (author)
Kim, J (author)
Kim, J (author)
Kim, K (author)
Kim, K (author)
Kim, S (author)
Kim, Y (author)
Kim, Y (author)
Kirk, PDW (author)
Kitano, H (author)
Klambauer, G (author)
Knowles, D (author)
Ko, M (author)
Kohn-Luque, A (author)
Kooistra, AJ (author)
Kuenemann, MA (author)
Kuiper, M (author)
Kurz, C (author)
Kwon, M (author)
van Laarhoven, T (author)
Laegreid, A (author)
Lederer, S (author)
Lee, H (author)
Lee, J (author)
Lee, YW (author)
Leppaho, E (author)
Lewis, R (author)
Li, J (author)
Li, L (author)
Liley, J (author)
Lim, WK (author)
Lin, C (author)
Liu, YY (author)
Lopez, Y (author)
Low, J (author)
Lysenko, A (author)
Machado, D (author)
Madhukar, N (author)
De Maeyer, D (author)
Malpartida, AB (author)
Mamitsuka, H (author)
Marabita, F (author)
Karolinska Institutet
Marchal, K (author)
Marttinen, P (author)
Mason, D (author)
Mazaheri, A (author)
Mehmood, A (author)
Mehreen, A (author)
Michaut, M (author)
Miller, RA (author)
Mitsopoulos, C (author)
Modos, D (author)
Van Moerbeke, M (author)
Moo, K (author)
Motsinger-Reif, A (author)
Movva, R (author)
Muraru, S (author)
Muratov, E (author)
Mushthofa, M (author)
Nagarajan, N (author)
Nakken, S (author)
Nath, A (author)
Neuvial, P (author)
Newton, R (author)
Ning, Z (author)
De Niz, C (author)
Oliva, B (author)
Olsen, C (author)
Palmeri, A (author)
Panesar, B (author)
Papadopoulos, S (author)
Park, J (author)
Park, S (author)
Park, S (author)
Pawitan, Y (author)
Peluso, D (author)
Pendyala, S (author)
Peng, J (author)
Perfetto, L (author)
Pirro, S (author)
Plevritis, S (author)
Politi, R (author)
Poon, H (author)
Porta, E (author)
Prellner, I (author)
Preuer, K (author)
Pujana, MA (author)
Ramnarine, R (author)
Reid, JE (author)
Reyal, F (author)
Richardson, S (author)
Ricketts, C (author)
Rieswijk, L (author)
Rocha, M (author)
Rodriguez-Gonzalvez, C (author)
Roell, K (author)
Rotroff, D (author)
de Ruiter, JR (author)
Rukawa, P (author)
Sadacca, B (author)
Safikhani, Z (author)
Safitri, F (author)
Sales-Pardo, M (author)
Sauer, S (author)
Schlichting, M (author)
Seoane, JA (author)
Serra, J (author)
Shang, MM (author)
Karolinska Institutet
Sharma, A (author)
Sharma, H (author)
Shen, Y (author)
Shiga, M (author)
Shin, M (author)
Shkedy, Z (author)
Shopsowitz, K (author)
Sinai, S (author)
Skola, D (author)
Smirnov, P (author)
Soerensen, IF (author)
Soerensen, P (author)
Song, JH (author)
Song, SO (author)
Soufan, O (author)
Spitzmueller, A (author)
Steipe, B (author)
Suphavilai, C (author)
Tamayo, SP (author)
Tamborero, D (author)
Karolinska Institutet
Tang, J (author)
Tanoli, ZUR (author)
Tarres-Deulofeu, M (author)
Tegner, J (author)
Karolinska Institutet
Thommesen, L (author)
Tonekaboni, SAM (author)
Tran, H (author)
De Troyer, E (author)
Truong, A (author)
Tsunoda, T (author)
Turu, G (author)
Tzeng, GY (author)
Verbeke, L (author)
Videla, S (author)
Vis, D (author)
Voronkov, A (author)
Votis, K (author)
Wang, A (author)
Wang, HQH (author)
Wang, PW (author)
Wang, S (author)
Wang, W (author)
Wang, XC (author)
Wang, X (author)
Wennerberg, K (author)
Wernisch, L (author)
Wessels, L (author)
van Westen, GJP (author)
Westerman, BA (author)
White, SR (author)
Willighagen, E (author)
Wurdinger, T (author)
Xie, L (author)
Xie, SL (author)
Xu, H (author)
Yadav, B (author)
Yau, C (author)
Yeerna, H (author)
Yin, JW (author)
Yu, M (author)
Yu, M (author)
Yun, SJ (author)
Zakharov, A (author)
Zamichos, A (author)
Zanin, M (author)
Zeng, L (author)
Zenil, H (author)
Zhang, F (author)
Zhang, PY (author)
Zhang, W (author)
Zhao, HY (author)
Zhao, L (author)
Zheng, WJ (author)
Zoufir, A (author)
Zucknick, M (author)
show less...
 (creator_code:org_t)
2019-06-17
2019
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2674-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
NATURVETENSKAP  -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
NATURAL SCIENCES  -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Find more in SwePub

By the author/editor
Menden, MP
Wang, D
Mason, MJ
Szalai, B
Bulusu, KC
Guan, YF
show more...
Yu, T
Kang, J
Jeon, M
Wolfinger, R
Nguyen, T
Zaslavskiy, M
Jang, IS
Ghazoui, Z
Ahsen, ME
Vogel, R
Neto, EC
Norman, T
Tang, EKY
Garnett, MJ
Di Veroli, GY
Fawell, S
Stolovitzky, G
Guinney, J
Dry, JR
Saez-Rodriguez, ...
Abante, J
Abecassis, BS
Aben, N
Aghamirzaie, D
Aittokallio, T
Akhtari, FS
Al-lazikani, B
Alam, T
Allam, A
Allen, C
de Almeida, MP
Altarawy, D
Alves, V
Amadoz, A
Anchang, B
Antolin, AA
Ash, JR
Aznar, VR
Ba-alawi, W
Bagheri, M
Bajic, V
Ball, G
Ballester, PJ
Baptista, D
Bare, C
Bateson, M
Bender, A
Bertrand, D
Wijayawardena, B
Boroevich, KA
Bosdriesz, E
Bougouffa, S
Bounova, G
Brouwer, T
Bryant, B
Calaza, M
Calderone, A
Calza, S
Capuzzi, S
Carbonell-Caball ...
Carlin, D
Carter, H
Castagnoli, L
Celebi, R
Cesareni, G
Chang, H
Chen, GC
Chen, HR
Chen, HY
Cheng, LJ
Chernomoretz, A
Chicco, D
Cho, KH
Cho, S
Choi, D
Choi, J
Choi, K
Choi, M
De Cock, M
Coker, E
Cortes-Ciriano, ...
Cserzo, M
Cubuk, C
Curtis, C
Van Daele, D
Dang, CC
Dijkstra, T
Dopazo, J
Draghici, S
Drosou, A
Dumontier, M
Ehrhart, F
Eid, FE
ElHefnawi, M
Elmarakeby, H
van Engelen, B
Engin, HB
de Esch, I
Evelo, C
Falcao, AO
Farag, S
Fernandez-Lozano ...
Fisch, K
Flobak, A
Fornari, C
Foroushani, ABK
Fotso, DC
Fourches, D
Friend, S
Frigessi, A
Gao, F
Gao, XT
Gerold, JM
Gestraud, P
Ghosh, S
Gillberg, J
Godoy-Lorite, A
Godynyuk, L
Godzik, A
Goldenberg, A
Gomez-Cabrero, D
Gonen, M
de Graaf, C
Gray, H
Grechkin, M
Guimera, R
Guney, E
Haibe-Kains, B
Han, Y
Hase, T
He, D
He, LY
Heath, LS
Hellton, KH
Helmer-Citterich ...
Hidalgo, MR
Hidru, D
Hill, SM
Hochreiter, S
Hong, S
Hovig, E
Hsueh, YC
Hu, ZY
Huang, JK
Huang, RS
Hunyady, L
Hwang, J
Hwang, TH
Hwang, W
Hwang, Y
Isayev, O
Walk, OBD
Jack, J
Jahandideh, S
Ji, JD
Jo, Y
Kamola, PJ
Kanev, GK
Karacosta, L
Karimi, M
Kaski, S
Kazanov, M
Khamis, AM
Khan, SA
Kiani, NA
Kim, A
Kim, J
Kim, K
Kim, S
Kim, Y
Kirk, PDW
Kitano, H
Klambauer, G
Knowles, D
Ko, M
Kohn-Luque, A
Kooistra, AJ
Kuenemann, MA
Kuiper, M
Kurz, C
Kwon, M
van Laarhoven, T
Laegreid, A
Lederer, S
Lee, H
Lee, J
Lee, YW
Leppaho, E
Lewis, R
Li, J
Li, L
Liley, J
Lim, WK
Lin, C
Liu, YY
Lopez, Y
Low, J
Lysenko, A
Machado, D
Madhukar, N
De Maeyer, D
Malpartida, AB
Mamitsuka, H
Marabita, F
Marchal, K
Marttinen, P
Mason, D
Mazaheri, A
Mehmood, A
Mehreen, A
Michaut, M
Miller, RA
Mitsopoulos, C
Modos, D
Van Moerbeke, M
Moo, K
Motsinger-Reif, ...
Movva, R
Muraru, S
Muratov, E
Mushthofa, M
Nagarajan, N
Nakken, S
Nath, A
Neuvial, P
Newton, R
Ning, Z
De Niz, C
Oliva, B
Olsen, C
Palmeri, A
Panesar, B
Papadopoulos, S
Park, J
Park, S
Pawitan, Y
Peluso, D
Pendyala, S
Peng, J
Perfetto, L
Pirro, S
Plevritis, S
Politi, R
Poon, H
Porta, E
Prellner, I
Preuer, K
Pujana, MA
Ramnarine, R
Reid, JE
Reyal, F
Richardson, S
Ricketts, C
Rieswijk, L
Rocha, M
Rodriguez-Gonzal ...
Roell, K
Rotroff, D
de Ruiter, JR
Rukawa, P
Sadacca, B
Safikhani, Z
Safitri, F
Sales-Pardo, M
Sauer, S
Schlichting, M
Seoane, JA
Serra, J
Shang, MM
Sharma, A
Sharma, H
Shen, Y
Shiga, M
Shin, M
Shkedy, Z
Shopsowitz, K
Sinai, S
Skola, D
Smirnov, P
Soerensen, IF
Soerensen, P
Song, JH
Song, SO
Soufan, O
Spitzmueller, A
Steipe, B
Suphavilai, C
Tamayo, SP
Tamborero, D
Tang, J
Tanoli, ZUR
Tarres-Deulofeu, ...
Tegner, J
Thommesen, L
Tonekaboni, SAM
Tran, H
De Troyer, E
Truong, A
Tsunoda, T
Turu, G
Tzeng, GY
Verbeke, L
Videla, S
Vis, D
Voronkov, A
Votis, K
Wang, A
Wang, HQH
Wang, PW
Wang, S
Wang, W
Wang, XC
Wang, X
Wennerberg, K
Wernisch, L
Wessels, L
van Westen, GJP
Westerman, BA
White, SR
Willighagen, E
Wurdinger, T
Xie, L
Xie, SL
Xu, H
Yadav, B
Yau, C
Yeerna, H
Yin, JW
Yu, M
Yun, SJ
Zakharov, A
Zamichos, A
Zanin, M
Zeng, L
Zenil, H
Zhang, F
Zhang, PY
Zhang, W
Zhao, HY
Zhao, L
Zheng, WJ
Zoufir, A
Zucknick, M
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Pharmaceutical S ...
NATURAL SCIENCES
NATURAL SCIENCES
and Computer and Inf ...
and Bioinformatics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Nature communica ...
By the university
Karolinska Institutet

Search outside SwePub

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view