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Mortality in patien...
Mortality in patients with psoriatic arthritis in Sweden: a nationwide, population-based cohort study
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- Exarchou, Sofia (författare)
- Lund Univ, Dept Clin Sci Malmö, Rheumatol, Malmö, Sweden.
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- Di Giuseppe, Daniela (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Klingberg, Eva (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Dept Rheumatol, Gothenburg, Sweden.
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- Sigurdardottir, Valgerdur (författare)
- Uppsala universitet,Centrum för klinisk forskning Dalarna,Falun Cent Hosp, Dept Rheumatol, Falun, Sweden.
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- Wedren, Sara (författare)
- Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Rheumatol, Stockholm, Sweden.
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- Lindström, Ulf (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Turesson, Carl (författare)
- Lund Univ, Dept Clin Sci Malmö, Rheumatol, Malmö, Sweden.;Skane Univ Hosp Malmö, Dept Rheumatol, Malmö, Sweden.
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- Jacobsson, Lennart T. H., 1954 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research,Univ Gothenburg, Sahlgrenska Acad, Dept Rheumatol & Inflammat Res, Gothenburg, Sweden.
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- Askling, Johan (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Solna, Clin Epidemiol Div, Stockholm, Sweden.
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- Wallman, Johan K. (författare)
- Lund Univ, Dept Clin Sci Lund, Lund, Sweden.;Skane Univ Hosp Lund, Dept Rheumatol, Lund, Sweden.
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Karolinska Institutet Lund Univ, Dept Clin Sci Malmö, Rheumatol, Malmö, Sweden (creator_code:org_t)
- BMJ Publishing Group Ltd, 2024
- 2024
- Engelska.
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Ingår i: ANNALS OF THE RHEUMATIC DISEASES. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 83:4, s. 446-456
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- ObjectivesTo compare all-cause mortality and causes of death between patients with psoriatic arthritis (PsA) and the general population in Sweden.MethodsAdults with at least one main PsA diagnosis (International Classification of Diseases-10: L40.5/M07.0-M07.3) from outpatient rheumatology/internal medicine departments 2001-2017 were identified from the National Patient Register. Each case was matched to five population comparator-subjects on sex/county/age at the case's first arthritis diagnosis. Follow-up ran from 1 January 2007, or from first PsA diagnosis thereafter, until death, emigration or 31 December 2018. Mortality was assessed overall, and stratified by sex and duration since diagnosis (diagnosis before/after 1 January 2007), using matched Cox proportional hazard regression (excluding/including adjustments for comorbidity) or Breslow test, as appropriate. Incidence rate ratios (IRR) of death, overall and stratified by sex/duration since diagnosis/age, as well as causes of death in PsA cases and comparator-subjects were also described.ResultsAll-cause mortality was elevated in PsA (HR: 1.11 (95% CI: 1.07 to 1.16); IRR: 1.18 (95% CI: 1.13 to 1.22)), mainly driven by increased risks in women (HR: 1.23 (95% CI: 1.16 to 1.30)) and cases with longer time since diagnosis (HR: 1.18 (95% CI: 1.12 to 1.25)). IRR of death were significantly increased for all ages except below 40 years, with the numerically highest point-estimates for ages 40-59 years. When adjusted for comorbidity, however, the elevated mortality risk in PsA disappeared. Causes of death were similar among PsA cases/comparator-subjects, with cardiovascular disease and malignancy as the leading causes.ConclusionsMortality risk in PsA in Sweden was about 10% higher than in the general population, driven by excess comorbidity and with increased risks mainly in women and patients with longer disease duration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- Arthritis
- Psoriatic
- Epidemiology
- Mortality
- Cause of Death
- Sweden
- Arthritis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Exarchou, Sofia
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Di Giuseppe, Dan ...
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Klingberg, Eva
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Sigurdardottir, ...
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Wedren, Sara
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Lindström, Ulf
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Turesson, Carl
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Jacobsson, Lenna ...
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Askling, Johan
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Wallman, Johan K ...
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Göteborgs universitet
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Karolinska Institutet
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