Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations

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Prediagnostic blood selenium status and mortality among patients with colorectal cancer in western european populations

Baker, Jacqueline Roshelli (författare): Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States

Umesh, Sushma (författare): Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States

Jenab, Mazda (författare): International Agency for Research on Cancer, Lyon, France

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Schomburg, Lutz (författare): Institut für Experimentelle Endokrinologie, Charité Universitätsmedizin Berlin, Berlin, Germany

Tjønneland, Anne (författare): Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark

Olsen, Anja (författare): Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark

Boutron-Ruault, Marie-Christine (författare): CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France

Rothwell, Joseph A. (författare): CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France

Severi, Gianluca (författare): CESP (UMR1018), Faculté de Médecine, Université Paris-Saclay, Inserm, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy

Katzke, Verena (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Johnson, Theron (författare): Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Schulze, Matthias B. (författare): Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutrition Science, University of Potsdam, Nuthetal, Germany

Masala, Giovanna (författare): Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy

Agnoli, Claudia (författare): Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

Simeon, Vittorio (författare): Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, Università degli Studi della Campania ‘Luigi Vanvitelli’, Naples, Italy

Tumino, Rosario (författare): Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy

Bueno-De-mesquita, H. Bas (författare): Center for Nutrition and Health, National Institute for Public Health and the Environment, Bilthoven, Netherlands

Gram, Inger Torhild (författare): Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway

Skeie, Guri (författare): Department of Community Medicine, The Arctic University of Norway, Tromsø, Norway

Bonet, Catalina (författare): Unitat de Nutrició i Càncer, Malaga, Spain

Rodriguez-Barranco, Miguel (författare): Escuela Andaluza de Salud Pública (EASP), Instituto de Investigación Biosanitaria ibs. Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

Houerta, José María (författare): Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain

Gylling, Björn, 1978- (författare): Umeå universitet,Patologi

Van Guelpen, Bethany (författare): Umeå universitet,Onkologi

Perez-Cornago, Aurora (författare): Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

Aglago, Elom (författare): International Agency for Research on Cancer, Lyon, France

Freisling, Heinz (författare): International Agency for Research on Cancer, Lyon, France

Weiderpass, Elisabete (författare): International Agency for Research on Cancer, Lyon, France

Cross, Amanda J. (författare): School of Public Health, Imperial College London, London, United Kingdom

Heath, Alicia K. (författare): School of Public Health, Imperial College London, London, United Kingdom

Hughes, David J. (författare): Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland

Fedirko, Veronika (författare): Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, TX, Houston, United States

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2021-10-22
2021
Engelska.
Ingår i: Biomedicines. - : MDPI. - 2227-9059. ; 9:11

Relaterad länk:: https://doi.org/10.3...; visa fler...; https://umu.diva-por... (primary) (Raw object); https://www.mdpi.com...; https://urn.kb.se/re...; https://doi.org/10.3...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multi-variable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; Ptrend = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; Ptrend = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; Ptrend = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; Ptrend = 0.17) for overall mortal-ity. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Cohort
Colorectal cancer
Selenium
Selenoprotein P
Survival
Oncology
onkologi

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Av lärosätet: Umeå universitet

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