Job strain as a risk factor for coronary heart disease: A collaborative meta-analysis of individual participant data

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Job strain as a risk factor for coronary heart disease : A collaborative meta-analysis of individual participant data

Kivimäki, M. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Theorell, Töres (författare): Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet

Batty, G. D. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

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Fransson, Eleonor, 1971- (författare): Jönköping University,Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden; Jönköping University, Sweden,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,HHJ. Åldrande - livsvillkor och hälsa

Heikkilä, K. (författare): Finnish Institute of Occupational Health, Helsinki, Finland

Alfredsson, L. (författare): Karolinska Institutet

Bjorner, J. B. (författare): National Research Centre for the Working Environment, Copenhagen, Denmark

Borritz, M. (författare): Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark

Burr, H. (författare): Federal Institute for Occupational Safety and Health (BAuA), Berlin, Germany

Casini, A. (författare): School of Public Health, Université Libre de Bruxelles, Brussels, Belgium

Clays, E. (författare): Department of Public Health, Ghent University, Ghent, Belgium

De Bacquer, D. (författare): Department of Public Health, Ghent University, Ghent, Belgium

Dragano, N. (författare): Department of Medical Sociology, University of Düsseldorf, Düsseldorf, Germany

Ferrie, J. E. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Geuskens, G. A. (författare): TNO, Hoofddorp, Netherlands

Goldberg, M. (författare): Versailles-Saint Quentin University, Versailles, France,Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Hamer, M. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom,National Research Centre for the Working Environment, Copenhagen, Denmark

Hooftman, W. E. (författare): Karolinska Institutet

Houtman, I. L. (författare): TNO, Hoofddorp, Netherlands

Westerholm, Peter J. M. (författare): Uppsala universitet,Arbets- och miljömedicin

Jokela, M. (författare): Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland

Kittel, F. (författare): School of Public Health, Université Libre de Bruxelles, Brussels, Belgium

Knutsson, Anders (författare): Mittuniversitetet,Institutionen för hälsovetenskap (-2013)

Koskenvuo, M. (författare): Department of Public Health, University of Helsinki, Helsinki, Finland

Koskinen, A. (författare): Finnish Institute of Occupational Health, Helsinki, Finland,School of Sociology, Social Policy and Social Work, Queen's University Belfast, Belfast, United Kingdom

Kouvonen, A. (författare): School of Sociology, Social Policy and Social Work, Queen's University Belfast, Belfast, United Kingdom

Kumari, M. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Madsen, I. E. H. (författare): National Research Centre for the Working Environment, Copenhagen, Denmark

Marmot, M. G. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Nielsen, M. L. (författare): Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark

Nordin, Maria (författare): Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden

Oksanen, T. (författare): Finnish Institute of Occupational Health, Turku, Finland

Pentti, J. (författare): Finnish Institute of Occupational Health, Turku, Finland

Rugulies, R. (författare): National Research Centre for the Working Environment, Copenhagen, Denmark

Salo, P. (författare): Finnish Institute of Occupational Health, Turku, Finland

Siegrist, J. (författare): Department of Medical Sociology, University of Düsseldorf, Düsseldorf, Germany

Singh-Manoux, A. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Suominen, S. B. (författare): Department of Public Health, University of Turku, Turku, Finland

Väänänen, A. (författare): Finnish Institute of Occupational Health, Helsinki, Finland

Vahtera, J. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Virtanen, M. (författare): Finnish Institute of Occupational Health, Helsinki, Finland

Westerholm, P. J. M. (författare): Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland

Westerlund, Hugo (författare): Stockholms universitet,Stressforskningsinstitutet

Zins, M. (författare): Versailles-Saint Quentin University, Versailles, France

Steptoe, A. (författare): Department of Epidemiology and Public Health, University College London, London WC1E 6BT, United Kingdom

Theorell, T. (författare): Stress Research Institute, Stockholm University, Stockholm, Sweden

Nyberg, Solja (författare)

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Elsevier, 2012
2012
Engelska.
Ingår i: The Lancet. - : Elsevier. - 0140-6736 .- 1474-547X. ; 380:9852, s. 1491-1497

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Tidskriftsartikel (refereegranskat)

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Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985-2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1•49 million person-years at risk (mean follow-up 7•5 years [SD 1•7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1•23 (95% CI 1•10-1•37). This effect estimate was higher in published (1•43, 1•15-1•77) than unpublished (1•16, 1•02-1•32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1•31, 1•15-1•48) and 5 years (1•30, 1•13-1•50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3•4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: The Lancet

Av lärosätet: Mittuniversitetet; Umeå universitet; Stockholms universitet; Karolinska Institutet; Uppsala universitet; Jönköping University

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Job strain as a risk factor for coronary heart disease : A collaborative meta-analysis of individual participant data

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