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Expression of Nesti...
Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer
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Kruger, K (författare)
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Wik, E (författare)
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Knutsvik, G (författare)
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visa fler...
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Nalwoga, H (författare)
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Klingen, TA (författare)
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Arnes, JB (författare)
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Chen, Y (författare)
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Mannelqvist, M (författare)
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Dimitrakopoulou, K (författare)
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Stefansson, IM (författare)
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Birkeland, E (författare)
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Aas, T (författare)
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- Tobin, NP (författare)
- Karolinska Institutet
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Jonassen, I (författare)
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- Bergh, J (författare)
- Karolinska Institutet
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Foulkes, WD (författare)
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Akslen, LA (författare)
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visa färre...
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(creator_code:org_t)
- 2017-04-24
- 2017
- Engelska.
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Ingår i: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 1089-
- Relaterad länk:
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https://www.nature.c...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We here examined whether Nestin, by protein and mRNA levels, could be a predictor of BRCA1 related breast cancer, a basal-like phenotype, and aggressive tumours. Immunohistochemical staining of Nestin was done in independent breast cancer hospital cohorts (Series I-V, total 1257 cases). Also, TCGA proteomic data (n = 103), mRNA microarray data from TCGA (n = 520), METABRIC (n = 1992), and 6 open access breast cancer datasets (n = 1908) were analysed. Patients with Nestin protein expression in tumour cells more often had BRCA1 germline mutations (OR 8.7, p < 0.0005, Series III), especially among younger patients (<40 years at diagnosis) (OR 16.5, p = 0.003). Nestin protein positivity, observed in 9–28% of our hospital cases (Series I-IV), was independently associated with reduced breast cancer specific survival (HR = 2.0, p = 0.035) and was consistently related to basal-like differentiation (by Cytokeratin 5, OR 8.7–13.8, p < 0.0005; P-cadherin OR 7.0–8.9, p < 0.0005; EGFR staining, OR 3.7–8.2, p ≤ 0.05). Nestin mRNA correlated significantly with Nestin protein expression (ρ = 0.6, p < 0.0005), and high levels were seen in the basal-like intrinsic subtype. Gene expression signalling pathways linked to high Nestin were explored, and revealed associations with stem-like tumour features. In summary, Nestin was strongly associated with germline BRCA1 related breast cancer, a basal-like phenotype, reduced survival, and stemness characteristics.
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- Av författaren/redakt...
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Kruger, K
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Wik, E
-
Knutsvik, G
-
Nalwoga, H
-
Klingen, TA
-
Arnes, JB
-
visa fler...
-
Chen, Y
-
Mannelqvist, M
-
Dimitrakopoulou, ...
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Stefansson, IM
-
Birkeland, E
-
Aas, T
-
Tobin, NP
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Jonassen, I
-
Bergh, J
-
Foulkes, WD
-
Akslen, LA
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visa färre...
- Artiklar i publikationen
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Scientific repor ...
- Av lärosätet
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Karolinska Institutet