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Sökning: onr:"swepub:oai:DiVA.org:umu-202637" > Interactions betwee...

Interactions between genome-wide significant genetic variants and circulating concentrations of 25-Hydroxyvitamin D in relation to prostate cancer risk in the National Cancer Institute BPC3

Dimitrakopoulou, Vasiliki I. (författare)
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece
Travis, Ruth C. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Shui, Irene M. (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
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Mondul, Alison (författare)
Department of Epidemiology, School of Public Health, University of Michigan, MI, Ann Arbor, United States
Albanes, Demetrius (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Virtamo, Jarmo (författare)
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland
Agudo, Antonio (författare)
Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICOIDIBELL), Barcelona, Spain
Boeing, Heiner (författare)
Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany
Bueno-De-Mesquita, H. Bas (författare)
Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Gunter, Marc J. (författare)
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
Johansson, Mattias (författare)
Umeå universitet,Enheten för biobanksforskning,Genetic Epidemiology Group, Genetics Section, International Agency for Research on Cancer, Lyon, France
Khaw, Kay-Tee (författare)
Cambridge Institute of Public Health, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom
Overvad, Kim (författare)
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark
Palli, Domenico (författare)
Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy
Trichopoulou, Antonia (författare)
Hellenic Health Foundation, Athens, Greece; Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
Giovannucci, Edward (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States
Hunter, David J. (författare)
Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Lindström, Sara (författare)
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Willett, Walter (författare)
Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Gaziano, J. Michael (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Department of Medicine, Harvard Medical School, MA, Boston, United States; Division of Aging, Department of Medicine, Brigham and Women's Hospital, MA, Boston, United States
Stampfer, Meir (författare)
Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Berg, Christine (författare)
Early Detection Research Group, Division of Cancer Prevention, National Cancer Institute, MD, Bethesda, United States
Berndt, Sonja I. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Black, Amanda (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Hoover, Robert N. (författare)
Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, United States
Kraft, Peter (författare)
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
Key, Timothy J. (författare)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
Tsilidis, Konstantinos K. (författare)
Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Stavros Niarchos Avenue, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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 (creator_code:org_t)
2017-02-17
2017
Engelska.
Ingår i: American Journal of Epidemiology. - : Oxford University Press (OUP). - 0002-9262 .- 1476-6256. ; 185:6, s. 452-464
Relaterad länk:
https://academic.oup...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Genome-wide association studies (GWAS) have identified over 100 single nucleotide polymorphisms (SNPs) associated with prostate cancer. However, information on the mechanistic basis for some associations is limited. Recent research has been directed towards the potential association of Vitamin D concentrations and prostate cancer, but little is known about whether the aforementioned genetic associations are modified by Vitamin D. We investigated the associations of 46 GWAS-identified SNPs, circulating concentrations of 25-hydroxyVitamin D (25 (OH)D), and prostate cancer (3,811 cases, 511 of whom died from the disease, compared with 2,980 controls- from 5 cohort studies that recruited participants over several periods beginning in the 1980s). We used logistic regression models with data from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) to evaluate interactions on the multiplicative and additive scales. After allowing for multiple testing, none of the SNPs examined was significantly associated with 25(OH)D concentration, and the SNP-prostate cancer associations did not differ by these concentrations. A statistically significant interaction was observed for each of 2 SNPs in the 8q24 region (rs620861 and rs16902094), 25(OH)D concentration, and fatal prostate cancer on both multiplicative and additive scales (P ≥ 0.001). We did not find strong evidence that associations between GWASidentified SNPs and prostate cancer are modified by circulating concentrations of 25(OH)D. The intriguing interactions between rs620861 and rs16902094, 25(OH)D concentration, and fatal prostate cancer warrant replication.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

Nyckelord

25-hydroxyvitamin D
BPC3
gene-environment interactions
genome-wide association studies
prostate cancer

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