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Alcohol Intake and Risk of Coronary Heart Disease in Younger, Middle-Aged, and Older Adults
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- Hvidtfeldt, Ulla A. (författare)
- Univ So Denmark, Alcohol Res Ctr, Natl Inst Publ Hlth, DK-1399 Copenhagen K, Denmark.;Univ Copenhagen, Dept Publ Hlth, Social Med Sect, Copenhagen, Denmark.,Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA.
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- Tolstrup, Janne S. (författare)
- Univ So Denmark, Alcohol Res Ctr, Natl Inst Publ Hlth, DK-1399 Copenhagen K, Denmark.
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- Jakobsen, Marianne U. (författare)
- Aarhus Univ Hosp, Dept Clin Epidemiol, Aalborg, Denmark.
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- Univ So Denmark, Alcohol Res Ctr, Natl Inst Publ Hlth, DK-1399 Copenhagen K, Denmark;Univ Copenhagen, Dept Publ Hlth, Social Med Sect, Copenhagen, Denmark. Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med,Channing Lab, Boston, MA 02115 USA. (creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2010
- 2010
- Engelska.
- Ingår i: Circulation. - : LIPPINCOTT WILLIAMS & WILKINS. - 0009-7322 .- 1524-4539. ; 121:14, s. 1589-1597
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Background-Light to moderate alcohol consumption is associated with a reduced risk of coronary heart disease. This protective effect of alcohol, however, may be confined to middle-aged or older individuals. Coronary heart disease incidence is low in men <40 years of age and in women <50 years of age; for this reason, study cohorts rarely have the power to investigate the effects of alcohol on coronary heart disease risk in younger adults. This study examined whether the beneficial effect of alcohol on coronary heart disease depends on age. Methods and Results-In this pooled analysis of 8 prospective studies from North America and Europe including 192 067 women and 74 919 men free of cardiovascular diseases, diabetes, and cancers at baseline, average daily alcohol intake was assessed at baseline with a food frequency or diet history questionnaire. An inverse association between alcohol and risk of coronary heart disease was observed in all age groups; hazard ratios among moderately drinking men (5.0 to 29.9 g/d) 39 to 50, 50 to 59, and >= 60 years of age were 0.58 (95% confidence interval [CI], 0.36 to 0.93), 0.72 (95% CI, 0.60 to 0.86), and 0.85 (95% CI, 0.75 to 0.97) compared with abstainers. However, the analyses indicated a smaller incidence rate difference between abstainers and moderate consumers in younger adults (incidence rate difference, 45 per 100 000; 90% CI, 8 to 84) than in middle-aged (incidence rate difference, 64 per 100 000; 90% CI, 24 to 102) and older (incidence rate difference, 89 per 100 000; 90% CI, 44 to 140) adults. Similar results were observed in women. Conclusion-Alcohol is also associated with a decreased risk of coronary heart disease in younger adults; however, the absolute risk was small compared with middle-aged and older adults. (Circulation. 2010; 121: 1589-1597.)
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Nyckelord
- age groups
- alcohol consumption
- coronary disease
- epidemiology
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