Search: WFRF:(Workalemahu Tsegaselassie) >
Quality control and...
Quality control and conduct of genome-wide association meta-analyses
-
Winkler, Thomas W. (author)
-
Day, Felix R. (author)
-
Croteau-Chonka, Damien C. (author)
-
show more...
-
Wood, Andrew R. (author)
-
Locke, Adam E. (author)
-
Maegi, Reedik (author)
-
Ferreira, Teresa (author)
-
- Fall, Tove (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Graff, Mariaelisa (author)
-
Justice, Anne E. (author)
-
Luan, Jian'an (author)
-
- Gustafsson, Stefan (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
-
Randall, Joshua C. (author)
-
Vedantam, Sailaja (author)
-
Workalemahu, Tsegaselassie (author)
-
Kilpelainen, Tuomas O. (author)
-
Scherag, Andre (author)
-
Esko, Tonu (author)
-
Kutalik, Zoltan (author)
-
Heid, Iris M. (author)
-
Loos, Ruth J. F. (author)
-
show less...
-
(creator_code:org_t)
- 2014-04-24
- 2014
- English.
-
In: Nature Protocols. - : Springer Science and Business Media LLC. - 1754-2189 .- 1750-2799. ; 9:5, s. 1192-1212
- Related links:
-
https://europepmc.or...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta- level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Winkler, Thomas ...
-
Day, Felix R.
-
Croteau-Chonka, ...
-
Wood, Andrew R.
-
Locke, Adam E.
-
Maegi, Reedik
-
show more...
-
Ferreira, Teresa
-
Fall, Tove
-
Graff, Mariaelis ...
-
Justice, Anne E.
-
Luan, Jian'an
-
Gustafsson, Stef ...
-
Randall, Joshua ...
-
Vedantam, Sailaj ...
-
Workalemahu, Tse ...
-
Kilpelainen, Tuo ...
-
Scherag, Andre
-
Esko, Tonu
-
Kutalik, Zoltan
-
Heid, Iris M.
-
Loos, Ruth J. F.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Medical Biotechn ...
-
and Medical Biotechn ...
- Articles in the publication
-
Nature Protocols
- By the university
-
Uppsala University
-
Karolinska Institutet