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Increased Genetic R...
Increased Genetic Risk for b-Cell Failure Is Associated With b-Cell Function Decline in People With Prediabetes
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- Billings, Liana K. (författare)
- NorthShore University HealthSystem
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- Jablonski, Kathleen A. (författare)
- George Washington University
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- Pan, Qing (författare)
- George Washington University
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visa fler...
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- Florez, Jose C. (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Franks, Paul W. (författare)
- Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
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- Goldberg, Ronald B. (författare)
- University of Miami
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- Hivert, Marie France (författare)
- Harvard Pilgrim Health Care Institute,Massachusetts General Hospital
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- Kahn, Steven E. (författare)
- Washington University School of Medicine
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- Knowler, William C. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Lee, Christine G. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Merino, Jordi (författare)
- Harvard Medical School,Novo Nordisk Foundation Centre for Basic Metabolic Research,Massachusetts General Hospital,Broad Institute
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- Huerta-Chagoya, Alicia (författare)
- Massachusetts General Hospital,Broad Institute
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- Mercader, Josep M. (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Raghavan, Sridharan (författare)
- University of Colorado School of Medicine,U.S. Department of Veterans Affairs
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- Shi, Zhuqing (författare)
- NorthShore University HealthSystem
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- Srinivasan, Shylaja (författare)
- University of California, San Francisco
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- Xu, Jianfeng (författare)
- NorthShore University HealthSystem
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- Udler, Miriam S. (författare)
- Harvard Medical School,Broad Institute,Massachusetts General Hospital
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(creator_code:org_t)
- 2024
- 2024
- Engelska 9 s.
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Ingår i: Diabetes. - 0012-1797. ; 73:8, s. 1352-1360
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Partitioned polygenic scores (pPS) have been developed to capture pathophysiologic processes underlying type 2 diabetes (T2D). We investigated the association of T2D pPS with diabetes-related traits and T2D incidence in the Diabetes Prevention Program. We generated five T2D pPS (b-cell, proinsulin, liver/lipid, obesity, lipodystrophy) in 2,647 participants randomized to intensive lifestyle, metformin, or placebo arms. Associations were tested with general linear models and Cox regression with adjustment for age, sex, and principal components. Sensitivity analyses included adjustment for BMI. Higher b-cell pPS was associated with lower insulinogenic index and corrected insulin response at 1-year follow-up with adjustment for baseline measures (effect per pPS SD 20.04, P = 9.6 × 1027, and 28.45 lU/mg, P = 5.6 × 1026, respec-tively) and with increased diabetes incidence with adjustment for BMI at nominal significance (hazard ratio 1.10 per SD, P = 0.035). The liver/lipid pPS was associated with reduced 1-year baseline-adjusted triglyceride levels (effect per SD 24.37, P = 0.001). There was no significant interaction between T2D pPS and randomized groups. The remaining pPS were associated with baseline measures only. We conclude that despite interventions for diabetes prevention, participants with a high genetic burden of the b-cell cluster pPS had worsening in measures of b-cell function.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Diabetes
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- Av författaren/redakt...
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Billings, Liana ...
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Jablonski, Kathl ...
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Pan, Qing
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Florez, Jose C.
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Franks, Paul W.
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Goldberg, Ronald ...
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visa fler...
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Hivert, Marie Fr ...
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Kahn, Steven E.
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Knowler, William ...
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Lee, Christine G ...
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Merino, Jordi
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Huerta-Chagoya, ...
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Mercader, Josep ...
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Raghavan, Sridha ...
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Shi, Zhuqing
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Srinivasan, Shyl ...
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Xu, Jianfeng
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Udler, Miriam S.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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Diabetes
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Lunds universitet