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Increased Inflammat...
Increased Inflammatory Activity in Patients 3 Months after Myocardial Infarction with Nonobstructive Coronary Arteries
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- Hjort, Marcus (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Eggers, Kai M., 1962- (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Lindhagen, Lars (författare)
- Karolinska Institutet,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Agewall, Stefan (författare)
- Karolinska Institutet,Univ Oslo, Inst Clin Sci, Oslo Univ Hosp, Oslo, Norway
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- Brolin, Elin B. (författare)
- Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci Intervent & Technol, Stockholm, Sweden
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- Collste, Olov (författare)
- Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
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- Daniel, Maria (författare)
- Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
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- Ekenbäck, Christina (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden
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- Frick, Mats (författare)
- Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
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- Henareh, Loghman (författare)
- Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden
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- Hofman-Bang, Claes (författare)
- Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden
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- Malmqvist, Karin (författare)
- Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden
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- Spaak, Jonas (författare)
- Karolinska Institutet,Danderyd Hosp, Dept Clin Sci, Div Cardiovasc Med, Stockholm, Sweden
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- Sörensson, Peder (författare)
- Karolinska Institutet,Karolinska Univ Hosp, Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
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- Y-Hassan, Shams (författare)
- Karolinska Univ Hosp, Dept Med, Heart & Vasc Theme, Stockholm, Sweden
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- Tornvall, Per (författare)
- Karolinska Institutet,Soder Sjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden
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- Lindahl, Bertil, 1957- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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(creator_code:org_t)
- 2019-08-01
- 2019
- Engelska.
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Ingår i: Clinical Chemistry. - : AMER ASSOC CLINICAL CHEMISTRY. - 0009-9147 .- 1530-8561. ; 65:8, s. 1023-1030
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Around 5%-10% of patients with myocardial infarction (MI) present with nonobstructive coronary arteries (MINOCA). We aimed to assess pathophysiological mechanisms in MINOCA by extensively evaluating cardiovascular biomarkers in the stable phase after an event, comparing MINOCA patients with cardiovascular healthy controls and MI patients with obstructive coronary artery disease (MI-CAD).METHODS: Ninety-one biomarkers were measured with a proximity extension assay 3 months after MI in 97 MINOCA patients, 97 age-and sex-matched MI-CAD patients, and 98 controls. Lasso analyses (penalized logistic regression models) and adjusted multiple linear regression models were used for statistical analyses.RESULTS: In the Lasso analysis (MINOCA vs MI-CAD), 8 biomarkers provided discriminatory value: P-selectin glycoprotein ligand 1, C-X-C motif chemokine 1, TNF-related activation-induced cytokine, and pappalysin-1 (PAPPA) with increasing probabilities of MINOCA, and tissue-type plasminogen activator, B-type natriuretic peptide, myeloperoxidase, and interleukin-1 receptor antagonist protein with increasing probabilities of MI-CAD. Comparing MINOCA vs controls, 7 biomarkers provided discriminatory value: N-terminal pro-B-type natriuretic peptide, renin, NF-kappa-B essential modulator, PAPPA, interleukin-6, and soluble urokinase plasminogen activator surface receptor with increasing probabilities of MINOCA, and agouti-related protein with increasing probabilities of controls. Adjusted multiple linear regression analyses showed that group affiliation was associated with the concentrations of 7 of the 8 biomarkers in the comparison MINOCA vs MI-CAD and 5 of the 7 biomarkers in MINOCA vs controls.CONCLUSIONS: Three months after the MI, the biomarker concentrations indicated greater inflammatory activity in MINOCA patients than in both MI-CAD patients and healthy controls, and a varying degree of myocardial dysfunction among the 3 cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
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- Av författaren/redakt...
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Hjort, Marcus
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Eggers, Kai M., ...
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Lindhagen, Lars
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Agewall, Stefan
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Brolin, Elin B.
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Collste, Olov
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visa fler...
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Daniel, Maria
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Ekenbäck, Christ ...
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Frick, Mats
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Henareh, Loghman
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Hofman-Bang, Cla ...
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Malmqvist, Karin
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Spaak, Jonas
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Sörensson, Peder
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Y-Hassan, Shams
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Tornvall, Per
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Lindahl, Bertil, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
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Clinical Chemist ...
- Av lärosätet
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Uppsala universitet
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Karolinska Institutet