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Serum fetuin-a conc...
Serum fetuin-a concentration and endothelial dysfunction in chronic kidney disease
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Caglar, K (författare)
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Yilmaz, MI (författare)
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Saglam, M (författare)
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Cakir, E (författare)
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Kilic, S (författare)
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Sonmez, A (författare)
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Eyileten, T (författare)
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Yenicesu, M (författare)
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Oguz, Y (författare)
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Tasar, M (författare)
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Vural, A (författare)
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Ikizler, TA (författare)
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- Stenvinkel, P (författare)
- Karolinska Institutet
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- Lindholm, B (författare)
- Karolinska Institutet
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visa färre...
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(creator_code:org_t)
- 2008-03-11
- 2008
- Engelska.
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Ingår i: Nephron. Clinical practice. - : S. Karger AG. - 1660-2110. ; 108:3, s. C233-C240
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- <i>Background:</i> Defective endothelial function, an initial step in the development of atherosclerotic plaque, is prevalent in moderate to advanced chronic kidney disease (CKD). In this study, the investigators hypothesized that fetuin-A, a calcification inhibitor, is a novel risk factor for the development of endothelial dysfunction in patients. <i>Methods:</i> 198 nondiabetic patients with a mean age of 44.0 ± 12.4 years and with different stages of CKD were studied. In addition to a detailed metabolic panel, flow-mediated dilatation assessed by high-resolution brachial ultrasonography was performed to determine endothelial dysfunction. Carotid intima-media thickness was also estimated by ultrasonography. Serum fetuin-A concentrations were determined by using a human ELISA method. <i>Results:</i> Endothelial dysfunction was observed in all stages (1–5) of CKD and worsened in parallel to the reduction in estimated glomerular filtration rate. Serum fetuin-A concentrations were also found to be decreased in all but stage 1 CKD. On multiple regression analysis, endothelial dysfunction was independently associated with fetuin-A (β = 0.745, p < 0.001) and intact parathyroid hormone concentrations (β = –0.216, p < 0.001). <i>Conclusion:</i> These data in a selected cohort of CKD patients indicate that fetuin-A may be one of the contributing factors for the development of endothelial dysfunction in CKD patients.
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Till lärosätets databas
- Av författaren/redakt...
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Caglar, K
-
Yilmaz, MI
-
Saglam, M
-
Cakir, E
-
Kilic, S
-
Sonmez, A
-
visa fler...
-
Eyileten, T
-
Yenicesu, M
-
Oguz, Y
-
Tasar, M
-
Vural, A
-
Ikizler, TA
-
Stenvinkel, P
-
Lindholm, B
-
visa färre...
- Artiklar i publikationen
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Nephron. Clinica ...
- Av lärosätet
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Karolinska Institutet