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Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools

Feng, Xiaoshuang (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Wu, Wendy Yi-Ying (författare)
Umeå universitet,Onkologi
Onwuka, Justina Ucheojor (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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Haider, Zahra (författare)
Umeå universitet,Onkologi
Alcala, Karine (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Smith-Byrne, Karl (författare)
Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom
Zahed, Hana (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Guida, Florence (författare)
Environment and Lifestyle Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Wang, Renwei (författare)
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
Bassett, Julie K. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia
Stevens, Victoria (författare)
Rollins School of Public Health, Emory University, GA, Atlanta, United States
Wang, Ying (författare)
American Cancer Society, GA, Atlanta, United States
Weinstein, Stephanie (författare)
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
Freedman, Neal D. (författare)
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Rockville, United States
Chen, Chu (författare)
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, WA, Seattle, United States
Tinker, Lesley (författare)
Women's Health Initiative Clinical Coordinating Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States
Nøst, Therese Haugdahl (författare)
Department of Community Medicine, University of Tromsø, Arctic University of Norway, Tromsø, Norway
Koh, Woon-Puay (författare)
Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore
Muller, David (författare)
Division of Genetic Medicine, Imperial College London School of Public Health, London, United Kingdom
Colorado-Yohar, Sandra M. (författare)
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
Tumino, Rosario (författare)
Hyblean Association for Epidemiological Research, Ragusa, Italy
Hung, Rayjean J. (författare)
Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada
Amos, Christopher I. (författare)
Institute for Clinical and Translational Research, Baylor College of Medicine, TX, Houston, United States
Lin, Xihong (författare)
Department of Biostatistics, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Statistics, Harvard University, MA, Cambridge, United States
Zhang, Xuehong (författare)
Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States
Arslan, Alan A. (författare)
Department of Population Health, New York University School of Medicine, New York, NY, USA
Sánchez, Maria-Jose (författare)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ib, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
Sørgjerd, Elin Pettersen (författare)
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
Severi, Gianluca (författare)
Inserm, Université Paris-Saclay, Villejuif, France
Hveem, Kristian (författare)
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway
Brennan, Paul (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Langhammer, Arnulf (författare)
HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Levanger, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway
Milne, Roger L. (författare)
Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia
Yuan, Jian-Min (författare)
Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
Melin, Beatrice S. (författare)
Umeå universitet,Onkologi
Johansson, Mikael (författare)
Umeå universitet,Onkologi
Robbins, Hilary A. (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
Johansson, Mattias (författare)
Genomic Epidemiology Branch, International Agency for Research on Cancer, Lyon, France
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 (creator_code:org_t)
Oxford University Press, 2023
2023
Engelska.
Ingår i: Journal of the National Cancer Institute. - : Oxford University Press. - 0027-8874 .- 1460-2105. ; 115:9, s. 1050-1059
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test.METHODS: We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years prior to lung cancer diagnosis and 624 smoking-matched cancer free participants who were assayed for 302 proteins. We used 470 case-control pairs from 4 cohorts to select proteins and train a protein-based risk model. We subsequently used 154 case-control pairs from 2 cohorts to compare the risk-discriminatory performance of the protein-based model with that of the Early Cancer Detection Test (EarlyCDT)-Lung and the PLCOm2012 model using receiver operating characteristics analysis and by estimating models' sensitivity. All tests were 2-sided.RESULTS: The area under the curve for the protein-based risk model in the validation sample was 0.75 (95% confidence interval [CI] = 0.70 to 0.81) compared with 0.64 (95% CI = 0.57 to 0.70) for the PLCOm2012 model (Pdifference = .001). The EarlyCDT-Lung had a sensitivity of 14% (95% CI = 8.2% to 19%) and a specificity of 86% (95% CI = 81% to 92%) for incident lung cancer. At the same specificity of 86%, the sensitivity for the protein-based risk model was estimated at 49% (95% CI = 41% to 57%) and 30% (95% CI = 23% to 37%) for the PLCOm2012 model.CONCLUSION: Circulating proteins showed promise in predicting incident lung cancer and outperformed a standard risk prediction model and the commercialized EarlyCDT-Lung.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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