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Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Santoro, Aurelia (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy
Guidarelli, Giulia (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Ostan, Rita (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy
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Giampieri, Enrico (författare)
Department of Physics, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Fabbri, Cristina (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy
Bertarelli, Claudia (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Nicoletti, Claudio (författare)
Department of Experimental and Clinical Medicine, Section of Anatomy, University of Florence, Florence, Italy; Gut Health Institute Strategic Programme, Quadram Institute Bioscience, Norwich, UK
Kadi, Fawzi, 1970- (författare)
Örebro universitet,Institutionen för hälsovetenskaper
de Groot, Lisette C. P. G. M. (författare)
Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands
Feskens, Edith (författare)
Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands
Berendsen, Agnes (författare)
Department of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands
Brzozowska, Anna (författare)
Department of Human Nutrition, WULS-SGGW, Warsaw, Poland
Januszko, Olga (författare)
Department of Human Nutrition, WULS-SGGW, Warsaw, Poland
Kozlowska, Katarzyna (författare)
Department of Human Nutrition, WULS-SGGW, Warsaw, Poland
Fairweather-Tait, Susan (författare)
Norwich Medical School, University of East Anglia, Norwich, UK
Jennings, Amy (författare)
Norwich Medical School, University of East Anglia, Norwich, UK
Meunier, Nathalie (författare)
CHU Clermont-Ferrand, CRNH Auvergne, Clermont-Ferrand, France
Caumon, Elodie (författare)
CHU Clermont-Ferrand, CRNH Auvergne, Clermont-Ferrand, France
Napoli, Alessandro (författare)
Radiology Section, Department of Radiological, Oncological and Anatomopathological Sciences, Sapienza University of Rome, Rome, Italy
Mercatelli, Daniele (författare)
Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
Battista, Giuseppe (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Capri, Miriam (författare)
Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; C.I.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy
Franceschi, Claudio (författare)
Institute of Neurological Sciences (IRCCS), Bologna, Italy
Bazzocchi, Alberto (författare)
Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy; CI.G. Interdepartmental Centre "L. Galvani", Alma Mater Studiorum, University of Bologna, Bologna, Italy Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy (creator_code:org_t)
2019-02-04
2019
Engelska.
Ingår i: European Radiology. - : Springer. - 0938-7994 .- 1432-1084. ; 29:9, s. 4968-4979
Relaterad länk:
https://doi.org/10.1...
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https://link.springe...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • OBJECTIVES: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly Europeans.METHODS: A whole-body dual-energy X-ray absorptiometry (DXA) scan was made in 1121 healthy (65-79 years) women and men from five European countries of the "New dietary strategies addressing the specific needs of elderly population for a healthy aging in Europe" project (NCT01754012) cohort to measure markers of adipose and lean tissue and bone mass. Pro-inflammatory (IL-6, IL-6Rα, TNF-α, TNF-R1, TNF-R2, pentraxin 3, CRP, alpha-1-acid glycoprotein, albumin) and anti-inflammatory (IL-10, TGF-β1) molecules as well as adipose-related markers such as leptin, adiponectin, ghrelin, and resistin were measured by magnetic bead-based multiplex-specific immunoassays and biochemical assays.RESULTS: BC characteristics were different in elderly women and men, and more favorable BC markers were associated with a better adipose-related inflammatory profile, with the exception of skeletal muscle mass index. No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, glycoprotein 130, TNF-α-R1, and TNF-α-R2.CONCLUSIONS: The association between BC and inflammatory and adipose-related biomarkers is crucial in decoding aging and pathophysiological processes, such as sarcopenia. DXA can help in understanding how the measurement of fat and muscle is important, making the way from research to clinical practice.KEY POINTS: • Body composition markers concordantly associated positively or negatively with adipose-related and inflammatory markers, with the exception of skeletal muscle mass index. • No correlation was found with the body composition markers and circulating levels of some standard pro- and anti-inflammatory markers like IL-6, pentraxin 3, IL-10, TGF-β1, TNF-α, IL-6Rα, gp130, TNF-α-R1, and TNF-α-R2. • Skeletal muscle mass index (SMI) shows a good correlation with inflammatory profile in age-related sarcopenia.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Nyckelord

Aging
Body composition
DXA
Inflammation
Sarcopenia

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