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Risk of major adver...
Risk of major adverse liver outcomes among first-degree relatives of individuals with MASLD
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- Yang, Wen (författare)
- Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Ebrahimi, Fahim (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Clarunis Univ, Ctr Gastrointestinal & Liver Dis, Dept Gastroenterol & Hepatol, Basel, Switzerland.
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- Romeo, Stefano, 1976 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
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- Holmer, Magnus (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Upper GI, Div Hepatol, Stockholm, Sweden.
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- Vessby, Johan, 1972- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Ekstedt, Mattias (författare)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Mag- tarmmedicinska kliniken,Linköping Univ, Dept Gastroenterol & Hepatol, Dept Hlth Med & Caring Sci, Linköping, Sweden.
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- Ludvigsson, Jonas F. (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Örebro Univ Hosp, Dept Pediat, Örebro, Sweden.;Columbia Univ Coll Phys & Surg, Dept Med, New York, NY USA.
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- Shang, Ying (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.
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- Hagstrom, Hannes (författare)
- Karolinska Institutet,Karolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Upper GI, Div Hepatol, Stockholm, Sweden.
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Karolinska Institutet Karolinska Inst, Dept Med, Stockholm, Sweden (creator_code:org_t)
- WILEY, 2024
- 2024
- Engelska.
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Ingår i: LIVER INTERNATIONAL. - : WILEY. - 1478-3223 .- 1478-3231. ; 44:5, s. 1253-1264
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background & AimsPrevious studies have suggested an increased risk of major adverse liver outcomes (MALO) in relatives of patients with metabolic dysfunction-associated steatotic liver disease (MASLD). However, granular and longitudinal evidence is lacking on the future risk of MALO among family members of individuals with MASLD.MethodsWe identified 3526 first-degree relatives (FDRs) and 11 079 general population comparators to 1328 patients with MASLD diagnosed between 1974 and 2021, with detailed clinical data, including liver histology in 71% of patients. MALO was defined through diagnostic coding for cirrhosis or its complications. Cox regression models were used to estimate adjusted hazard ratios (aHRs) for MALO among FDRs compared to general population comparators. Cumulative incidence accounting for competing risks was calculated.ResultsDuring a median follow-up of 13.4 years, there were 65 (2%, 1.12/1000 person-years) and 225 (2%, 1.26/1000 person-years) MALO events in FDRs and general population comparators respectively. After adjusting for demographic factors and comorbidities, FDRs were at no increased risk of MALO (aHR = 0.99, 95% CI: 0.74-1.33). Increased relative rates of MALOs were, however, observed in some subgroups, including parents, although absolute risk estimates were low and comparable to the general population.ConclusionsFDRs of patients with MASLD did not have a higher rate of incident MALO than the general population. Since the absolute risk of MALO in relatives of patients with MASLD was low, these results do not support systematic screening of MASLD-related fibrosis in relatives of patients with MASLD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- first-degree relative
- genetic risk
- major adverse liver outcomes
- metabolic dysfunction-associated steatotic liver disease
- first-degree relative; genetic risk; major adverse liver outcomes; metabolic dysfunction-associated steatotic liver disease
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Yang, Wen
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Ebrahimi, Fahim
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Romeo, Stefano, ...
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Holmer, Magnus
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Vessby, Johan, 1 ...
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Ekstedt, Mattias
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Ludvigsson, Jona ...
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Shang, Ying
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Hagstrom, Hannes
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