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Combined ASRGL1 and...
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma
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- Huvila, J. (author)
- Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku
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- Laajala, T. D. (author)
- Univ Turku, Dept Math & Stat, Pl20, Helsinki 00014, Finland;Univ Helsinki, FIMM, Inst Mol Med Finland, Pl20, FIN-00014 Helsinki, Finland,Helsingin Yliopisto,University of Helsinki,Turun Yliopisto,University of Turku
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- Edqvist, Per-Henrik D (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Uppsala University
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- Mardinoglu, Adil (author)
- KTH,Science for Life Laboratory, SciLifeLab,Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden,KTH Royal Inst Technol, Sci Life Lab, S-10044 Stockholm, Sweden;Chalmers Univ Technol, Dept Biol & Biol Engn, S-41296 Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)
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- Talve, L. (author)
- Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku
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- Pontén, Fredrik (author)
- Uppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala University
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- Grénman, S. (author)
- Univ Turku, Turku Univ Hosp, Dept Gynaecol & Obstet, Pl52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku
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- Carpén, O. (author)
- Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland;Univ Helsinki, Dept Pathol, Helsinki, Finland;Finland HUSIAB, Pl720, Helsinki 00029, Finland,Helsingin Yliopisto,University of Helsinki,Turun Yliopisto,University of Turku
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- Aittokallio, T. (author)
- Univ Turku, Dept Math & Stat, Pl20, Helsinki 00014, Finland;Univ Helsinki, FIMM, Inst Mol Med Finland, Pl20, FIN-00014 Helsinki, Finland,Turun Yliopisto,University of Turku,Helsingin Yliopisto,University of Helsinki
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- Auranen, A. (author)
- Univ Tampere, Tampere Univ Hosp, Dept Gynaecol & Obstet, Pl2000, Tampere 33521, Finland,Tampereen Yliopisto,University of Tampere
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(creator_code:org_t)
- Academic Press Inc. 2018
- 2018
- English.
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In: Gynecologic Oncology. - : Academic Press Inc.. - 0090-8258 .- 1095-6859. ; 149:1, s. 173-180
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Abstract
Subject headings
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- Objective: In clinical practise, prognostication of endometrial cancer is based on clinicopathological risk factors. The use of immunohistochemistry-based markers as prognostic tools is generally not recommended and a systematic analysis of their utility as a panel is lacking. We evaluated whether an immunohistochemical marker panel could reliably assess endometrioid endometrial cancer (EEC) outcome independent of clinicopathological information. Methods: A cohort of 306 EEC specimens was profiled using tissue microarray (TMA). Cost- and time-efficient immunohistochemical analysis of well-established tissue biomarkers (ER, PR, HER2, Ki-67, MLH1 and p53) and two new biomarkers (L1CAM and ASRGL1) was carried out. Statistical modelling with embedded variable selection was applied on the staining results to identify minimal prognostic panels with maximal prognostic accuracy without compromising generalizability. Results: A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P < 0.001) of dying of EEC compared to the low-risk group. Conclusions: P53 and ASRGL1 immunoprofiling stratifies EEC patients into three risk groups with significantly different outcomes. This simple and easily applicable panel could provide a useful tool in EEC risk stratification and guiding the allocation of treatment modalities.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- ASRGL1
- Endometrial cancer
- Modelling
- p53
- Prognostic
- Risk stratification
- antineoplastic agent
- asrg1 protein
- epidermal growth factor receptor 2
- estrogen receptor
- Ki 67 antigen
- l1cam protein
- MutL protein homolog 1
- progesterone receptor
- protein p53
- tumor marker
- unclassified drug
- adult
- aged
- Article
- brachytherapy
- cancer chemotherapy
- cancer grading
- cancer recurrence
- cancer surgery
- cancer survival
- disease specific survival
- endometrium carcinoma
- female
- follow up
- high risk patient
- histopathology
- human
- human tissue
- immunohistochemistry
- immunoreactivity
- low risk patient
- major clinical study
- middle aged
- overall survival
- priority journal
- recurrence free survival
- recurrent disease
- tissue microarray
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Huvila, J.
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Laajala, T. D.
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Edqvist, Per-Hen ...
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Mardinoglu, Adil
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Talve, L.
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Pontén, Fredrik
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show more...
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Grénman, S.
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Carpén, O.
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Aittokallio, T.
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Auranen, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Obstetrics Gynae ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Gynecologic Onco ...
- By the university
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Royal Institute of Technology
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Uppsala University
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Chalmers University of Technology