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Changes of the p16 ...
Changes of the p16 gene but not the p53 gene in human chondrosarcoma tissues.
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- Asp, Julia, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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Sangiorgi, L (author)
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- Inerot, Sven, 1948 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi,Institute of Surgical Sciences, Department of Orthopaedics
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- Lindahl, Anders, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin,Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
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Molendini, L (author)
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Benassi, M S (author)
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Picci, P (author)
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(creator_code:org_t)
- 2000
- 2000
- English.
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In: International journal of cancer. Journal international du cancer. - 0020-7136. ; 85:6, s. 782-6
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- The role of two important tumour suppressor genes, p16 and p53, was evaluated in cartilaginous tumour tissues. Genomic DNA from 22 chondrosarcomas, 5 benign chondroid tumours, 1 sample of reactive proliferative cartilage and 2 samples of normal cartilage were analysed using polymerase chain reaction, single strand conformational polymorphism, DNA sequencing and methylation-specific polymerase chain reaction. The p16 gene was found to be partly methylated in 5 high-grade chondrosarcomas and homozygously deleted in 1 chondrosarcoma. Moreover, a polymorphism was detected in 3 malignant tumours, but not in benign tumours or normal cartilage. Analysis of the p53 gene revealed an unchanged structure in all samples. These findings show a role for p16, but not p53, in chondrosarcoma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Adolescent
- Adult
- Aged
- Bone Neoplasms
- genetics
- Cartilage
- Child
- Chondrosarcoma
- genetics
- DNA Methylation
- Female
- Genes
- p16
- Genes
- p53
- Humans
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism
- Single-Stranded Conformational
- Sequence Analysis
- DNA
Publication and Content Type
- ref (subject category)
- art (subject category)
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Asp, Julia, 1973
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Sangiorgi, L
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Inerot, Sven, 19 ...
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Lindahl, Anders, ...
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Molendini, L
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Benassi, M S
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show more...
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Picci, P
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show less...
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