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Clinical characteristics and late effects in CNS tumours of childhood : Do not forget long term follow-up of the low grade tumours

Ehrstedt, Christoffer (author)
Uppsala universitet,Pediatrik
Kristiansen, Ingela (author)
Uppsala universitet,Pediatrik
Ahlsten, Gunnar (author)
Uppsala universitet,Pediatrik
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Casar Borota, Olivera (author)
Uppsala universitet,Klinisk och experimentell patologi
Dahl, Margareta, 1948- (author)
Uppsala universitet,Pediatrik
Libard, Sylwia (author)
Uppsala universitet,Klinisk och experimentell patologi,Irina Alfuzoff
Strömberg, Bo (author)
Uppsala universitet,Pediatrik
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 (creator_code:org_t)
Elsevier BV, 2016
2016
English.
In: European journal of paediatric neurology. - : Elsevier BV. - 1090-3798 .- 1532-2130. ; 20:4, s. 580-587
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Aim: To investigate clinical characteristics and late effects of CNS tumours in childhood with a special focus on low-grade tumours, especially low-grade astrocytoma and glib neuronal tumours. Methods: A retrospective population based study was performed at Uppsala University Children's Hospital, a tertiary referral centre for children with CNS tumours. Patients were identified from the National Brain Tumour Registry and the National Epilepsy Surgery Registry. Hospital medical records were analysed for patients with a follow up of >= 5 years after diagnosis. A re-evaluation of the neuro-pathological diagnosis was performed. Results: A total of 193 patients (age 0-17.99 years) during a twelve-year period (1995-2006) were included; 149 survived >= 5 years. Three larger subgroups could be identified: astrocytic, embryonal and glioneuronal tumours. A supratentorial location was found in 52%. Medical late effects were mainly neurological and endocrinological, affecting 81% and 26% of surviving patients. Cognitive late effects were a frequent finding in the whole group but also in low-grade astrocytoma and glioneuronal tumours (53% and 67%). Thirty per cent had some kind of pedagogic support in school. Conclusion: Late effects are common in long-term survivors of CNS tumours in childhood. Low-grade astrocytoma and glioneuronal tumours are no exception, and the findings support the need for long-term follow up.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Keyword

Childhood
CNS-tumour
Cognitive
Late effects
Low grade
Patologi
Pathology

Publication and Content Type

ref (subject category)
art (subject category)

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