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Polymorphisms in th...
Polymorphisms in the FK506 binding protein 5 gene are associated with attention deficit hyperactivity disorder and diurnal cortisol levels
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- Isaksson, Johan (författare)
- Uppsala universitet,Barn- och ungdomspsykiatri,Uppsala Univ, Dept Neurosci, Child & Adolescent Psychiat Unit, Uppsala, Sweden.
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- Allen, Marie (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Uppsala Univ, Dept Immunol Genet & Pathol, Genom, Uppsala, Sweden.
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- Nilsson, Kent W. (författare)
- Uppsala universitet,Centrum för klinisk forskning, Västerås,Uppsala Univ, Clin Res Ctr, Hosp Vastmanland, Uppsala, Sweden.
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- Lindblad, Frank (författare)
- Uppsala universitet,Barn- och ungdomspsykiatri,Uppsala Univ, Dept Neurosci, Child & Adolescent Psychiat Unit, Uppsala, Sweden.
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(creator_code:org_t)
- 2015-06-26
- 2015
- Engelska.
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Ingår i: Acta Paediatrica. - : WILEY. - 0803-5253 .- 1651-2227. ; 104:9, s. 910-915
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- AimPrevious studies have shown an association between childhood attention deficit hyperactivity disorder (ADHD) and a down-regulated hypothalamus-pituitary-adrenal axis (HPA axis) with low diurnal cortisol levels. Given the role of the FK506 binding protein 5 (FKBP5) as an important regulator of the negative feedback system of the HPA axis, we set out to investigate possible associations between single nucleotide polymorphisms (SNPs) in FKBP5 in relation to ADHD and diurnal cortisol levels. MethodsChildren with ADHD (n=81) and healthy comparisons (n=88) collected saliva four times during a regular school day for radioimmunoassay analysis of cortisol and for genotyping of five SNPs in FKBP5 (rs9296158, rs1360780, rs9470080, rs7748266 and rs9394309). ResultsWe found associations between SNP genotypes and ADHD as well as between genotypes and diurnal cortisol levels. One of these SNPs, rs9470080, was significantly associated with both ADHD and lower cortisol levels. ConclusionThis study contributes to previous findings on a down-regulated HPA axis in children with ADHD by demonstrating an association between ADHD, lower cortisol levels and SNPs of the FKBP5-gene. The relevance of these findings for the development and shaping of ADHD symptoms needs to be approached in larger samples, preferably also taking stress reactivity into consideration.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Nyckelord
- Attention deficit hyperactivity disorder
- Cortisol
- Feedback regulation
- FK506 binding protein 5
- Hypothalamus-pituitary-adrenal axis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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